obsolete deletion of short arm of chromosome 1 (1p) associated meningioma

Based on the search results, it appears that there are specific symptoms associated with meningiomas that have deleted the short arm of chromosome 1 (1p). Here are some possible signs and symptoms:

• Tumor progression: The loss of chromosome 1p is associated with early recurrence and tumor progression [12].
• Short survival and worse prognosis: Loss of chromosome 9p, which is frequently found in anaplastic meningiomas, is also associated with short survival and a worse prognosis [12].
• Grade 3 meningioma symptoms: A Grade 3 meningioma, which is cancerous and the most aggressive and difficult to treat, may exhibit symptoms such as headaches, seizures, personality changes, weakness or numbness of the face or limbs, and/or vision changes [11].

It's worth noting that these symptoms are not specific to 1p deletion-associated meningiomas but can be associated with other types of meningiomas as well.

References:

[12] The combination of 1p and 14q loss is shown to be an independent prognostic factor for the WHO grade and is associated with early recurrence and tumor progression. [11] A Grade 3 meningioma will most likely regrow. This grade is cancerous and the most aggressive and difficult to treat. [13] Loss of 1p is most common in Grade 1 meningioma.

Diagnostic Tests for Meningioma Associated with 1p Deletion

Meningiomas are a type of brain tumor that can be associated with deletions in the short arm of chromosome 1 (1p). The diagnostic tests for this condition involve imaging exams and physical examinations.

• Imaging Exams: MRI and CT scans are commonly used to create detailed images of the brain. These tests can help identify tumors and determine their size, location, and characteristics [2][3].
• Contrast-Enhanced MRI: This type of MRI uses a contrast agent to highlight the tumor and surrounding tissues. It is particularly useful for detecting calcification within the tumor [7].
• Physical Examination: A thorough neurological exam is conducted by a neurologist to assess any symptoms or abnormalities in the nervous system.
• Imaging Tests with Contrast Dye: An imaging test using contrast dye can help diagnose meningioma and determine its characteristics [4][6].

Additional Diagnostic Tools

Recent studies have also explored the use of molecular data and histologic grading to improve diagnostic precision. For example, a three-tiered score that integrates histologic and molecular data has been shown to significantly improve stratification in meningioma diagnosis [8].

Based on the search results, it appears that there are limited treatment options for meningiomas associated with the deletion of the short arm of chromosome 1 (1p). However, I found some relevant information in the context:

• There is a mention of a drug that inhibits the growth of aggressive meningiomas, but no specific details about its efficacy or association with 1p deletion [8].
• A study on sunitinib, a multitargeted tyrosine kinase inhibitor (TKI), found some clinical trial results in treating meningiomas, but it's unclear

The differential diagnosis of meningiomas with loss of the short arm of chromosome 1 (1p) involves distinguishing them from other types of tumors that may exhibit similar genetic characteristics.

According to various studies [10, 11, 12], the most common differential diagnoses for meningiomas with 1p deletion include:

• Solitary fibrous tumor/hemangiopericytoma (SFT/HPC): These are rare meningeal tumors that can be difficult to distinguish from meningiomas based on histological features alone [9, 11].
• Hemangioblastoma: This is a type of vascular tumor that can occur in the central nervous system and may exhibit similar genetic characteristics to meningiomas with 1p deletion [6, 12].
• Pituitary adenoma: While not typically associated with 1p deletion, pituitary adenomas can be considered in the differential diagnosis for meningiomas with this genetic characteristic [11].

In addition to these tumors, other entities may also need to be considered in the differential diagnosis of meningiomas with 1p deletion. These include:

• Atypical meningioma: This is a subtype of meningioma that can exhibit more aggressive behavior and may have different genetic characteristics than typical meningiomas [12].
• Malignant meningioma: This is a rare but aggressive form of meningioma that can be difficult to distinguish from other types of malignant brain tumors [11].

It's worth noting that the differential diagnosis for meningiomas with 1p deletion can be complex and may require a combination of clinical, radiological, and molecular features to accurately diagnose these tumors.