obsolete cancer by anatomical entity

Based on the provided context, it appears that there are various types of cancers that can be classified based on their anatomical location.

• A cancer that affects an anatomical entity is referred to as a malignant neoplasm of aortic body and other paraganglia (disorder) [1].
• The Disease Ontology (DO) has expanded anatomical mechanistic models for DO’s 12 ‘disease of anatomical entity’ branches, which include cancers affecting specific anatomical locations [2].

Some examples of cancers classified by anatomical location include:

• A large intestine cancer that is located in the colon and/or rectum [3].
• Carcinoma originating from peripheral scarring of lung tissue, referred to as "scarcinoma" [4].

It's worth noting that the DO also defines cell of origin models for DO’s 11 cell type cancer branches by identifying the most granular anatomical location and cell of origin SubClass Of statements for each [2].

Based on the provided context, it appears that there isn't specific information available on "obsolete cancer" as it's a term not commonly used in medical literature. However, I can provide you with general signs and symptoms of cancer, which might be relevant to your query.

Common Symptoms of Cancer

• Anorexia (loss of appetite) [1]
• Weakness and lethargy [1]
• Palpable tumor [1]
• Nervous symptoms such as stupor, coma, seizures [2]
• Urinary symptoms like polyuria-polydipsia [2]
• Digestive symptoms including anorexia, vomiting, diarrhea [2]
• Physical examination findings like enlarged supraclavicular lymphadenopathy, pleural effusion or lobar collapse, unresolved pneumonia, or signs of weight loss [3]

Symptoms by Anatomical Entity

While there isn't specific information on "obsolete cancer," I can provide you with general symptoms associated with different anatomical entities:

• Supraclavicular lymphadenopathy: Enlarged lymph nodes in the neck region [3]
• Pleural effusion or lobar collapse: Fluid accumulation in the pleural space or lung collapse, leading to respiratory symptoms [3]
• Unresolved pneumonia: Persistent infection of the lungs [3]

Other Symptoms

Additionally, some cancers can cause a range of other symptoms, including:

• Dyspnea (difficulty breathing) with increasing respiratory rate; Cough, intractable [4]
• Decline in systolic blood pressure to below 90 or progressive postural hypotension [4]
• Abdominal pain, fevers, hematuria and/or hypertension, urinary tract infection, constipation, and weight loss [8]

Please note that these symptoms can be non-specific and may not necessarily indicate cancer. A proper diagnosis requires a thorough medical evaluation by a healthcare professional.

References:

[1] SG Barreto (2010) [2] AI Baba (2007) [3] Aug 30, 2024 [4] Apr 16, 2021

Diagnostic Tests for Obsolete Cancer Types

The diagnostic tests for obsolete cancer types have evolved over time, and various methods have been used to classify and diagnose these neoplasms. According to [4], the Facility Oncology Registry Data Standards (FORDS) was developed in 2003 by the Commission on Cancer (CoC) of the American College of Surgeons to standardize cancer data collection.

Histomorphology

For over 150 years, pathologists have relied on histomorphology to classify and diagnose neoplasms. This method has been stunningly successful, permitting the accurate diagnosis of thousands of different types of neoplasms using only a microscope and a trained eye [14]. However, with the advent of cancer genomics, histomorphology's supremacy has been challenged by identifying genetic alterations shared among various cancers.

Conventional Diagnostic Microscopy

Conventional diagnostic microscopy, which relies on the identification of structural alterations and their effects on cellular and tissue function, will not be replaced any time soon by other forms of diagnostic testing [10]. This is due to its ease of use, affordability, and accuracy. As stated in [10], "it's undisputable that conventional diagnostic microscopy will remain a cornerstone in cancer diagnosis."

Other Diagnostic Tests

Other diagnostic tests, such as RT-PCR (Reverse Transcription Polymerase Chain Reaction), have been used to diagnose and sub-classify cancer cells [11]. However, the effectiveness of these tests can vary depending on the specific cancer type and the stage of the disease.

Limitations of Current Diagnostic Tests

Despite advances in diagnostic testing, there are still limitations to current methods. For example, RT-PCR can be used to identify a few cancer cells, but it's not clear if this should be a factor in choosing treatment options [11]. Additionally, conventional diagnostic microscopy may not always accurately diagnose certain types of cancers.

References

[4] The Facility Oncology Registry Data Standards (FORDS) was developed in 2003 by the Commission on Cancer (CoC) of the American College of Surgeons. [10] Conventional diagnostic microscopy will not be replaced any time soon by other forms of diagnostic testing. [11] RT-PCR can be used to sub-classify cancer cells, but its effectiveness is still being researched. [14] Histomorphology has been used for over 150 years to classify and diagnose neoplasms.

Treatment of Cancer Based on Anatomical Location May Become Obsolete

According to a recent study, researchers have found that the location of a tumor within the body may not be as crucial in determining treatment as previously thought. The study compared eight different types of cancerous tumors and found no correlation between the type of tumor (e.g., breast, lung, or colon) and how it should be treated.

This discovery could potentially lead to a shift away from treating cancer based on its anatomical location, which has been a long-standing approach in oncology. Instead, treatment may become more personalized and focused on the specific characteristics of each individual's tumor.

Implications for Cancer Treatment

The implications of this study are significant, as it suggests that the traditional approach to cancer treatment may be outdated. By moving away from anatomical location-based treatment, doctors may be able to develop more targeted and effective therapies that take into account the unique characteristics of each patient's cancer.

This could lead to improved outcomes for patients with cancer, as well as reduced side effects and complications associated with traditional treatments. However, further research is needed to fully understand the implications of this study and to determine how it will impact cancer treatment in the future.

References

• [10] The results of a new study at the School of Medicine could eventually have oncologists removing their specialties from their shingles by making therapy based on a tumor's anatomical location obsolete.
• [10] When the researchers compared eight different kinds of cancerous tumors, they saw that whether the tumor was, for instance, a breast tumor, lung tumor or colon tumor didn't correlate to how the ...

The differential diagnosis of obsolete cancer by anatomical entity can be a complex and challenging process, especially when dealing with rare or unusual cases.

According to the Commission on Cancer (CoC) of the American College of Surgeons, the first diagnosis of cancer may be clinical (i.e., based on clinical findings or physician's documentation), and it is essential to note that the date of diagnosis should not be changed [8].

When considering a differential diagnosis for obsolete cancer by anatomical entity, it is crucial to consider the histomorphological similarities between different tumor entities. For instance, the pancreatic head and the distal bile duct share a common embryonic development, which can explain the histomorphological similarities between pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) [11].

However, despite these similarities, there are also significant differences between PDAC and dCCA. These differences can make a differential diagnosis during routine diagnostic practice challenging [11]. Similarly, the existence of true branchiogenic carcinoma is controversial, and when such a diagnosis is contemplated, every effort should be made to detect a possible primary site [9].

In addition, the Facility Oncology Registry Data Standards (FORDS) developed by the Commission on Cancer (CoC) provides guidelines for cancer registration, including the classification of cancer by anatomical entity. However, it's worth noting that these standards may not always reflect the most up-to-date information or the latest classifications for lymphomas, leukemias, and brain tumors [3].

In summary, the differential diagnosis of obsolete cancer by anatomical entity requires a thorough understanding of the histomorphological similarities and differences between various tumor entities. It also necessitates consideration of the latest classifications and guidelines provided by reputable organizations such as the Commission on Cancer (CoC).

References:

[8] The first diagnosis of cancer may be clinical (i.e., based on clinical findings or physician's documentation). Note: Do not change the date of diagnosis when [8]. [9] The existence of true branchiogenic carcinoma is controversial. When such a diagnosis is contemplated, every effort should be made to detect a possible primary site [9]. [11] Pancreatic