obsolete malignant tumor of epidermal appendage

Malignant Tumors of Epidermal Appendages: An Overview

Malignant tumors of epidermal appendages are rare and aggressive neoplasms that arise from the skin's adnexal structures, such as hair follicles, sweat glands, and sebaceous glands. These tumors can occur at any age but are more common in elderly individuals.

Characteristics and Types

• Malignant epithelial neoplasms arising from sebaceous or sweat glands or from hair follicles [1]
• Can present as a painless mass and may be multifocal [5]
• Adenocarcinoma with sebaceous differentiation is an example of such tumors [6]

Classification and Terminology

• Malignant skin tumor with adnexal differentiation (disorder) [13]
• Malignant tumor of epidermal appendage (disorder) [4]
• Neoplasm of skin with adnexal differentiation (126489007) [15]

Risk and Prevalence

• Risk of malignant degeneration varies with individual lesions, and is more common with sweat gland tumors than pilosebaceous tumors [14]
• Appendageal tumors comprise a wide spectrum of benign and malignant neoplasms that exhibit morphological differentiation toward one or more adnexal structures in normal skin [14]

References

[1] Malignant epithelial neoplasm arising from sebaceous or sweat glands or from hair follicles. code. C3775.

[4] Malignant skin tumor with adnexal differentiation (disorder), FN, Full form of descriptor. Malignant tumor of epidermal appendage (disorder), OF, Obsolete fully ...

[5] An adenocarcinoma with sebaceous differentiation. It presents as a painless mass and it may be multifocal.

[6] A rare malignant neoplasm that arises from the sebaceous glands. Synonym. Malignant Neoplasm of Sebaceous Gland. Malignant Neoplasm of the Sebaceous Gland.

[13] An example is “transitional cell epidermoid carcinomas.” “Transitional cell carcinoma NOS” is M8120/3 and “epidermoid carcinoma NOS” is M8070/3. In such ...

[14] Risk of malignant degeneration varies with individual lesions, and is more common with sweat gland tumors than pilosebaceous tumors.

[15] Neoplasm of skin with adnexal differentiation (126489007); Tumor of epidermal appendage (126489007); Neoplasm of adnexa of skin (126489007); Skin appendage tumor (55681005)

Based on the provided context, it appears that you are looking for information on the signs and symptoms of a rare or obsolete malignant tumor of an epidermal appendage.

According to search result [3], a benign or malignant tumor involving the skin is mentioned. However, this does not specifically mention epidermal appendages.

Search result [5] mentions a condition called "Sterile Miliaria" which is characterized by the widespread eruption of sterile pustules, but it's not clear if this is related to an epidermal appendage.

However, search result [4] mentions that BCC in individuals with BCNS may appear during childhood as small acrochordon-like lesions. Acrochordons are a type of skin tag which can be considered as an epidermal appendage.

It's worth noting that the information provided is not specific to malignant tumors, and more context would be needed to provide a clear answer.

Here are some possible signs and symptoms:

• Small acrochordon-like lesions (Search result [4])
• Widespread eruption of sterile pustules (Search result [5])

Please note that these points are based on the provided context and might not be directly related to malignant tumors. More information would be needed to provide a clear answer.

References: [3] A benign or malignant tumor involving the skin. [4] BCC in individuals with BCNS may appear during childhood as small acrochordon-like lesions. [5] Sterile Miliaria is characterized by the widespread eruption of sterile pustules.

Diagnostic Tests for Malignant Tumor of Epidermal Appendage

The diagnostic tests for a malignant tumor of epidermal appendage, also known as a malignant skin appendage tumor, typically involve a combination of histological assessment and imaging studies.

• Histologic Assessment: The diagnosis is often made on histologic assessment of skin biopsy. A dermatopathologist examines the tissue sample to determine the presence of cancerous cells (1).
• Imaging Studies: Imaging studies such as MRI or CT scanning may be used to assess tumor extent and map out local invasion into nerves, muscle, cartilage, or bone (5).

Additional Diagnostic Tests

Other diagnostic tests that may be recommended include:

• Lab tests: Lab tests such as blood and urine samples may be used for diagnosing appendix cancer, determining the extent of the disease, and tracking the progress of treatment (13).
• Advanced genomic testing: Advanced genomic testing may also be recommended to examine the DNA of a tumor's cells, which can help in identifying the specific type of cancer and developing an effective treatment plan (13).

References

[1] Diagnosis is often made on histologic assessment of skin biopsy. ... Malignant skin appendage tumors. [5] Oct 3, 2024 — MRI or CT scanning may be used to assess tumor extent and map out local invasion into nerves, muscle, cartilage, or bone. [13] by JP North · Cited by 11 — This topic will review the clinical features, diagnosis, and treatment of cutaneous adnexal tumors and associated syndromes. Brooke-Spiegler ...

Based on the provided context, it appears that there are various types of malignant tumors originating from the epidermal appendages. Here's a summary of the available information:

• Cutaneous squamous cell carcinoma: This type of cancer is mentioned in points 1 and 2 as a form of malignant cutaneous epithelial tumor.
• Basal cell carcinoma (BCC) and Squamous Cell Carcinoma (SCC): These are two of the most common malignancies in the United States, often caused by exposure to UV radiation (point 8).
• Clear cell eccrine carcinomas: This is a rare type of skin cancer that affects the sweat glands, with nine reported cases (point 9).

Regarding treatment options for these types of cancers:

• EGFR inhibitors: These drugs have shown good application effects as tumor treatment drugs and are widely distributed in the epidermis of normal mammals (point 3).
• Talimogene laherparepvec and nivolumab: A phase II trial study is being conducted to assess the efficacy of this combination therapy for malignant sweat gland tumors, sebaceous carcinoma, and trichilemmal carcinoma (point 15).

It's essential to note that these treatment options might not be specific to obsolete malignant tumors of epidermal appendages. However, they are mentioned in the context as potential treatments for various types of skin cancers.

Current Treatment Options:

• EGFR inhibitors [3]
• Talimogene laherparepvec and nivolumab (phase II trial study) [15]

Types of Malignant Tumors:

• Cutaneous squamous cell carcinoma [1, 2]
• Basal cell carcinoma (BCC) and Squamous Cell Carcinoma (SCC) [8]
• Clear cell eccrine carcinomas [9]

The differential diagnosis for an obsolete malignant tumor of epidermal appendage involves considering various other conditions that may present with similar characteristics.

• Metastatic breast carcinoma and microcystic adnexal carcinoma are two potential differential diagnoses, as they can exhibit features similar to those of the obsolete malignant tumor in question [1].
• Malignant clear cell neoplasms in the skin also have a differential diagnosis that includes metastases from clear cell tumors of thyroid origin [3][7].
• Histological analysis is required to reach a definitive diagnosis, as the clinical appearance of these conditions can be nonspecific [8].

In terms of specific tumor types, apocrine-eccrine carcinomas and sebaceous carcinoma are two common histologic categories that may be considered in the differential diagnosis for an obsolete malignant tumor of epidermal appendage [9]. Microcystic adnexal carcinoma also has a classic differential diagnosis that includes desmoplastic trichoepithelioma, syringoma, and other conditions [10].

It's worth noting that surgical resection is often considered the standard of care for malignant adnexal cancers of the skin, although the efficacy of radiotherapy and targeted therapies may still be undetermined in some cases [6].