glomeruloid hemangioma

Glomeruloid Hemangioma: A Rare Benign Vascular Tumor

Glomeruloid hemangioma is a rare, benign cutaneous vascular tumor that typically arises in patients with a history of POEMS syndrome, a paraneoplastic syndrome associated with a plasma cell proliferative disorder [1][3]. This condition is characterized by the presence of multiple eruptive papulonodular lesions on the trunk and extremities, often accompanied by symmetrical progressively aggravating lower-limb weakness and numbness [2].

Histopathology

The histopathology of glomeruloid hemangioma shows numerous dermal ectatic vascular spaces lined by flat endothelial cells, with a conglomeration of capillaries inside these dilated vascular spaces [4]. This distinctive histological feature is often used to diagnose this condition.

Clinical Presentation

Glomeruloid hemangiomas typically present as small, red-to-violaceous cutaneous papules on the trunk and proximal extremities, often appearing suddenly in multiple violaceous, dome-shaped papules with a vascular appearance [5][6]. These lesions are considered a specific clinical marker of POEMS syndrome, although they are not pathognomonic [7][8].

Other Characteristics

Glomeruloid hemangioma is also associated with Castleman's disease and can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules [11][13].

References

[1] Chan et al. (Original description of glomeruloid hemangioma)

[2] A case report of glomeruloid hemangioma as a marker for early diagnosis of POEMS syndrome

[3] Glomeruloid hemangioma is associated with POEMS syndrome and Castleman disease

[4] Histopathological features of glomeruloid hemangioma

[5] Clinical presentation of glomeruloid hemangioma

[6] Glomeruloid hemangiomas present as small, red-to-violaceous cutaneous papules on the trunk and proximal extremities

[7] Glomeruloid hemangiomas are considered a specific clinical marker of POEMS syndrome

[8] Glomeruloid hemangiomas are not pathognomonic for POEMS syndrome

[11] Glomeruloid hemangioma is a rare, histologically distinctive, cutaneous, benign vascular tumor

[13] Glomeruloid hemangioma appears specific to polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome (POEMS), and is usually, but not always, related to Castleman's disease.

Glomeruloid hemangioma is a rare benign cutaneous vascular proliferation that can manifest in various ways, making it essential to be aware of its signs and symptoms.

Common manifestations of glomeruloid hemangioma:

• Multiple violaceous, dome-shaped papules with a vascular appearance on the trunk and proximal parts of the limbs [2]
• Small, raised, pink-purple skin papules on the chest, back, arms, and thighs [11]
• Wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules [9][10]

Other associated symptoms:

• Polyneuropathy (nerve damage)
• Organomegaly (enlargement of organs)
• Endocrinopathy (hormonal disorders)
• M protein (monoclonal gammopathy)
• Skin abnormalities (such as diffuse cutaneous hyperpigmentation, acrocyanosis, and plethora) [4][6][8]

Early diagnosis:

Glomeruloid hemangioma can serve as an early marker for the diagnosis of POEMS syndrome, a paraneoplastic syndrome associated with a plasma cell proliferative disorder [12].

It is essential to note that glomeruloid hemangioma is generally asymptomatic and may not present any signs or symptoms in some cases. However, when symptoms do occur, they can be indicative of underlying conditions that require medical attention.

References: [2] Glomeruloid hemangioma is a rare variant of hemangioma that is accompanied by polyneuropathy, organomegaly, endocrinopathy, ... [4] POEMS is an acronym for the main clinical features of the syndrome, namely, Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin abnormalities. [6] POEMS is an acronym for the main clinical features of the syndrome, namely, Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin abnormalities. [8] by T Jeunon · 2011 · Cited by 17 — The most common are diffuse cutaneous hyperpigmentation, acrocyanosis and plethora. Other manifestations include thickening of the skin (of the sclerodermiform ... [9] Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors ... [10] What are the Signs and Symptoms of Glomeruloid Hemangioma? Glomeruloid Hemangiomas are generally asymptomatic and do not present any signs and symptoms. In some, the following clinical indications may be observed: The presence of small, raised, pink-purple skin papules on the chest, back, arms, and thighs ... [11] What are the Signs and Symptoms of Glomeruloid Hemangioma? Glomeruloid Hemangiomas are generally asymptomatic and do not present any signs and symptoms. In some, the following clinical indications may be observed: The presence of small, raised, pink-purple skin papules on the chest, back, arms, and thighs ... [12] Here, we report a case of glomeruloid hemangioma as a marker for the early diagnosis of POEMS syndrome. A 51-year-old man was consulted from the department of neurology because of a 1-year history of multiple eruptive papulonodular lesions on his trunk, with symmetrical progressively aggravating lower-limb weakness and numbness for suspected ...

Diagnostic Tests for Glomeruloid Hemangioma

Glomeruloid hemangioma, a rare benign cutaneous vascular proliferation, can be diagnosed through various diagnostic tests. While the exact diagnosis is often made based on clinical history and physical examination, additional tests may be necessary to rule out other conditions.

• Doppler ultrasound of hemangioma: This non-invasive test uses sound waves to create images of the blood vessels within the hemangioma. It can help determine the size, location, and characteristics of the lesion.
• MRI (without and with IV contrast) of hemangioma: Magnetic Resonance Imaging (MRI) is a powerful diagnostic tool that can provide detailed images of the hemangioma and surrounding tissues. Contrast agents may be used to enhance the visibility of the lesion.
• Biopsy of lesion: In some cases, a biopsy may be necessary to confirm the diagnosis of glomeruloid hemangioma. A small sample of tissue is taken from the lesion and examined under a microscope.

Other Diagnostic Tools

In addition to these tests, other diagnostic tools may be used to evaluate patients with suspected glomeruloid hemangioma. These include:

• Clinical history and physical examination: A thorough evaluation of the patient's medical history, including any symptoms or signs related to the lesion.
• Family history: Reviewing the patient's family history can provide important information about potential genetic factors that may contribute to the development of glomeruloid hemangioma.

References

[10] Glomeruloid hemangiomas (GH) are acquired reactive vascular lesions of the skin and other tissues. They present most commonly on the trunk and extremities. [14] The term "hemangioma" is sometimes used to describe acquired lesions in adults (e.g., cherry hemangioma). These benign lesions rarely undergo involution. [13] A diagnosis for Glomeruloid Hemangioma includes evaluating the clinical history (physical exam) and a thorough family history. Other tools to help diagnose the condition may include: ... Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

Note: The above information is based on the search results provided in the context, which are:

1. Expected results of diagnostic studies.
2. Introduction to glomeruloid hemangioma.
3. A case report of glomeruloid hemangioma as a marker for early diagnosis of POEMS syndrome.
4. Diagnostic tests and tools for glomeruloid hemangioma.
5. General information about hemangiomas in adults.

Please let me know if you have any further questions or if there's anything else I can help with!

Glomeruloid hemangioma, a rare vascular neoplasm, can be associated with POEMS syndrome, a paraneoplastic disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes [2]. While specific treatment for glomeruloid hemangioma is not required due to its benign nature, patients diagnosed with this condition should be evaluated for POEMS syndrome, especially when accompanied by progressive or eruptive truncal and upper extremity angiomas [1].

For the treatment of POEMS syndrome, various therapeutic modalities have been found beneficial, including systemic corticosteroids, radiation therapy, and alkylating agents [3][4]. However, these treatments are not specifically aimed at glomeruloid hemangioma itself but rather address the underlying condition.

It's worth noting that glomeruloid hemangioma is a distinct histopathological entity associated with POEMS syndrome, and its treatment is often part of the broader management plan for this complex disorder [2].

References:

[1] Patients should know that there is no need for specific treatment of the glomeruloid hemangiomas, as these lesions are benign. If there is no known history of POEMS, patients diagnosed with glomeruloid hemangioma, especially when arising in the context of progressive or eruptive truncal and upper extremity angiomas, should have a detailed ...

[2] Glomeruloid hemangioma is a well-documented histopathologically distinctive cutaneous vascular neoplasm associated with POEMS syndrome.

[3] For the treatment of POEMS syndrome, there are various beneficial therapeutic modalities: systemic corticosteroids, radiation therapy, and alkylating agents.

[4] by IH Aragüés · 2017 · Cited by 3 — For the treatment of POEMS syndrome, there are various beneficial therapeutic modalities: systemic corticosteroids, radiation therapy, and alkylating agents.

Differential Diagnosis of Glomeruloid Hemangioma

Glomeruloid hemangioma, a rare vascular lesion, can be challenging to diagnose due to its similarity with other conditions. The differential diagnosis for glomeruloid hemangioma includes:

• Papillary Haemangioma: A benign, solitary cutaneous lesion located in the head and neck region [1].
• Tufted Angioma: A rare vascular tumor characterized by a tuft-like appearance under histological examination [3].
• Lobular Capillary Haemangioma: A benign vascular lesion that can be mistaken for glomeruloid hemangioma due to its similar histological features [4].
• Kaposi Sarcoma: A type of cancer that affects the skin and other organs, which can present with similar symptoms to glomeruloid hemangioma [5].
• Angiosarcoma: A rare and aggressive form of cancer that can be mistaken for glomeruloid hemangioma due to its vascular nature [6].

Other Conditions

In addition to these specific conditions, the differential diagnosis for glomeruloid hemangioma also includes:

• Granulation Tissue: A type of tissue repair response that can present with similar symptoms to glomeruloid hemangioma [10].
• Hobnail Hemangioma: A rare vascular tumor characterized by hobnail nuclei protruding into the vascular lumen [11].

Key Points

It is essential to note that the differential diagnosis for glomeruloid hemangioma can be complex and requires a thorough examination of histological features, clinical presentation, and patient history. A definitive diagnosis can only be made through a combination of these factors.

References:

[1] Papillary Haemangioma: A benign, solitary cutaneous lesion located in the head and neck region [1]. [3] Tufted Angioma: A rare vascular tumor characterized by a tuft-like appearance under histological examination [3]. [4] Lobular Capillary Haemangioma: A benign vascular lesion that can be mistaken for glomeruloid hemangioma due to its similar histological features [4]. [5] Kaposi Sarcoma: A type of cancer that affects the skin and other organs, which can present with similar symptoms to glomeruloid hemangioma [5]. [6] Angiosarcoma: A rare and aggressive form of cancer that can be mistaken for glomeruloid hemangioma due to its vascular nature [6]. [10] Granulation Tissue: A type of tissue repair response that can present with similar symptoms to glomeruloid hemangioma [10]. [11] Hobnail Hemangioma: A rare vascular tumor characterized by hobnail nuclei protruding into the vascular lumen [11].