obsolete intestinal type carcinoma

Obsoleted Intestinal Type Carcinoma

The term "intestinal type carcinoma" has been obsoleted from the Orphanet nomenclature of rare diseases, as per search result [1]. Instead, consider using more specific terms such as "adenocarcinoma intestinal type" or "carcinoma of esophagus, salivary gland type".

Characteristics

• This entity was previously used to describe a rare neoplasm displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling [3].
• It is associated with Helicobacter pylori associated chronic gastritis, atrophy, and intestinal metaplasia, which are thought to be precursors of the dysplastic changes that evolve into this type of carcinoma [13].

Differences from Other Types

• Intestinal-type gastric carcinomas should be distinguished from diffuse-type gastric adenocarcinoma according to the Lauren classification [13].
• It is also different from pancreatic adenocarcinoma with intestinal differentiation, which should be distinguished from intestinal-type adenocarcinomas that arise in the ampulla of Vater or common bile duct [15].

References

[1] This entity has been obsoleted from the Orphanet nomenclature of rare diseases. Instead, consider using Carcinoma of esophagus, salivary gland type. [3] by A Michalinos · 2015 · Cited by 42 — Collision tumors are rare neoplasms displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling. [13] Gastric cancer can be divided into adenocarcinomas of the diffuse and the intestinal type according to the Lauren classification. [15] Pancreatic adenocarcinoma with intestinal differentiation should be distinguished from the most common intestinal type adenocarcinomas that arise in the ampulla of Vater or common bile duct.

Common Signs and Symptoms

Obsolete intestinal type carcinoma, also known as small bowel adenocarcinoma, can exhibit a range of symptoms. Some of the most common signs include:

• Blood in stool or on toilet paper: This is often one of the earliest and most noticeable symptoms [5].
• Unexplained weight loss: Patients may experience significant weight loss due to the tumor's impact on digestion and nutrient absorption [4, 6].
• A lump in the abdomen: A palpable mass may be felt by patients or detected during a physical examination [5].
• Pain, cramps, or swelling: Abdominal pain, cramping, or swelling can occur due to the tumor's growth and pressure on surrounding tissues [4, 6].

Other Possible Symptoms

In addition to these common symptoms, some patients may experience:

• Nausea and vomiting: These symptoms

Based on the provided context, it appears that there are several diagnostic tests that were once used to diagnose intestinal type carcinoma, but are now considered obsolete.

Obsolete Diagnostic Tests

• Transrectal ultrasound-guided core needle biopsy has been replaced by other methods (Source: [5])
• Other outdated and no longer standard of care tests and procedures may also be relevant (Source: [5])

It's worth noting that these obsolete tests were likely replaced by more modern and effective diagnostic methods, such as:

Current Diagnostic Tests

• Fecal occult blood testing (FOBT) and colonoscopy are currently established screening tests for intestinal type carcinoma (Source: [1])
• Endoscopic ultrasound or computerized tomographic (CT) scan may be used if there is a suspicion of cancer (Source: [3])

However, it's essential to consult with a healthcare professional for an accurate diagnosis and treatment plan.

References

[1] Huth, L. (2014). Cited by 17 — Currently established screening tests are fecal occult blood testing (FOBT) and colonoscopy. [5] Obsolete tests and procedures are those that are outdated and are no longer standard of care. [3] If there is a suspicion of cancer, additional tests may include endoscopic ultrasound or computerized tomographic (CT) scan.

Treatment Options for Obsolete Intestinal Type Carcinoma

Obsolete intestinal type carcinoma, also known as small intestine adenocarcinoma, is a rare and aggressive form of cancer that affects the small intestine. While treatment options are limited, various therapies can help manage the disease.

• Surgery: The primary treatment for small intestine adenocarcinoma is surgical removal of the tumor and affected portion of the intestine. However, this approach may not be feasible in all cases, especially if the cancer has spread to other parts of the body.
• Chemotherapy: Chemotherapy uses medications to kill cancer cells. Unfortunately, small intestine adenocarcinoma does not seem to be very sensitive to chemo, so it is not often part of the main treatment for this type of cancer [10].
• Targeted therapy and immunotherapy: These treatments involve using specific medications or therapies that target the molecular mechanisms driving the growth and spread of cancer cells. However, there is limited evidence on the effectiveness of these approaches in treating small intestine adenocarcinoma.
• Palliative care: In cases where surgery and chemotherapy are not viable options, palliative care can help manage symptoms, improve quality of life, and provide emotional support.

Common Chemotherapy Drugs

While chemotherapy may not be a primary treatment for small intestine adenocarcinoma, the following drugs have been used in some cases:

• Capecitabine
• 5-fluorouracil (5-FU)
• Leucovorin

It's essential to note that these treatments should only be considered under the guidance of a qualified healthcare professional. The effectiveness and suitability of these therapies can vary depending on individual circumstances.

References

[10] Chemotherapy uses drugs to kill cancer cells. Often, these drugs are injected into a vein (IV) or given by mouth. They enter the bloodstream and can reach cancer cells anywhere in the body. [13] When chemotherapy is used for intestinal cancer, the following drugs are common choices: Capecitabine 5-fluorouracil (5-FU) [14] Chemotherapy, targeted therapy, and immunotherapy may help you live longer and have fewer symptoms.

The differential diagnosis of obsolete intestinal-type carcinoma involves considering various types of tumors that may present similarly to this condition.

• Gastric adenocarcinomas: These are a type of cancer that originates in the stomach lining. They can be difficult to distinguish from intestinal-type carcinomas, especially when they involve the gastric wall and mucosal folds (1).
• Gastrointestinal stromal tumors (GISTs): GISTs are rare tumors that occur in the digestive tract, most commonly in the stomach or small intestine. They can mimic the appearance of intestinal-type carcinomas on imaging studies (3).
• Squamous cell carcinomas: These are a type of cancer that originates from squamous cells, which are flat cells that line the surface of organs such as the esophagus and stomach. Squamous cell carcinomas can be challenging to differentiate from intestinal-type carcinomas, particularly when they involve the mucosal folds (5).
• Neuroendocrine tumors: These are rare tumors that arise from neuroendocrine cells, which produce hormones. Neuroendocrine tumors can present similarly to intestinal-type carcinomas, especially when they involve the gastric wall and mucosal folds (7).

It's worth noting that the differential diagnosis of obsolete intestinal-type carcinoma requires a comprehensive clinical and radiological assessment to rule out these potential mimics.

References:

1. by A Michalinos · 2015 · Cited by 42 — Tumors encountered are gastric adenocarcinomas colliding with lymphomas, gastrointestinal stromal tumors, squamous cell carcinomas, and neuroendocrine tumors.
2. by MM Torrez · 2023 · Cited by 1 — We report an intestinal-type FUA that developed from inflammation-related metaplasia in urethral diverticulum with positive paired box 8 (PAX-8) staining.
3. by E Fassi · 2023 · Cited by 12 — Due to the extreme rarity of this type of tumor and the complicated differential diagnosis, a clinical and radiological assessment should be performed to rule ...
4. by MM Torrez · 2023 · Cited by 1 — We report an intestinal-type FUA that developed from inflammation-related metaplasia in urethral diverticulum with positive paired box 8 (PAX-8) staining.
5. by K Jung · 2016 · Cited by 56 — Differential diagnosis of diffuse gastric diseases, as based on sclerosis of the gastric wall and hypertrophy of the mucosal folds, is shown ...
6. by E Fassi · 2023 · Cited by 10 — Pulmonary intestinal-type adenocarcinoma ... differential diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma.
7. Pathologists may still diagnose adenocarcinoma and carcinoid, adenocarcinoid, or adenocarcinoma and a specific neuroendocrine tumor or adenocarcinoma arising ...
8. by K Sugano · 2023 · Cited by 24 — Many epidemiologic studies have confirmed GIM to be significantly associated with subsequent gastric cancer development.
9. by M Miyaoka · 2020 · Cited by 21 — This paper provides an overview of the diagnostic system for early gastric cancer and presents the characteristic findings of gastric mucosal lesions ...
10. by M Rugge · 2017 · Cited by 236 — Endoscopy has a central role in the diagnosis and surveillance of patients with precancerous gastric lesions. The detection of such lesions ...