eccrine sweat gland cancer

Common Signs and Symptoms of Eccrine Sweat Gland Cancer

Eccrine sweat gland cancer, also known as eccrine carcinoma, can manifest in various ways, depending on the location and size of the tumor. While some people may not experience any symptoms at all, others may notice the following signs:

• Firm lump or nodule: A palpable mass that can be felt under the skin, often accompanied by a change in skin texture.
• Discoloration: The affected area may become discolored, ranging from mildly discolored to grey, blue, pink, and/or red.
• Smooth, bumpy, or rough skin: The skin overlying the tumor can appear smooth, bumpy, or rough to the touch.
• Itching or bleeding: Some individuals may experience itching or bleeding from the tumor site.

Early Symptoms

In some cases, eccrine sweat gland cancer can present with early symptoms, including:

• Firm lump
• Discoloration of affected area
• Smooth, bumpy and rough skin texture

Rare Cases

While rare, some individuals may experience more severe symptoms, such as:

• Local tissue destruction: The tumor can cause damage to surrounding tissues, leading to pain, swelling, or deformity.
• Metastasis: In advanced cases, the cancer can spread to other parts of the body, requiring more aggressive treatment.

Important Note

It's essential to note that not everyone with eccrine sweat gland cancer will experience symptoms. Some tumors may be small and asymptomatic, making regular skin checks crucial for early detection.

References:

• [2] - A solitary nodule of acral skin, often cystic. Papillary projections extend into a cystic space, sometimes with atypia, increased mitoses, invasion into bone.
• [7] - Early symptoms · Firm lump. · Discolouration of affected area, ranging from mildly discoloured, to grey, blue, pink and/or red. · Smooth, bumpy and rough skin texture.
• [14] - They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque).

The differential diagnosis of eccrine sweat gland cancer involves considering various other conditions that may present similarly to this type of cancer. According to the search results, some of these differential diagnoses include:

• Basal Cell Carcinoma [4]
• Cutaneous Squamous Cell Carcinoma [4]
• Dermatologic Manifestations of Merkel Cell Carcinoma [4]
• Metastatic disease from a primary breast, gastric, or bladder carcinoma [5]
• Neoplasms with clear cell differentiation, such as trichilemmal carcinoma, clear cell BCC and clear cell hidradenocarcinoma [7]
• Squamous cell carcinoma on superficial biopsies [8]
• Basal cell carcinoma, squamous cell carcinoma, Paget’s disease, melanoma, metastatic cancer, inflammatory, lymphocytic and vascular lesions [14]

It's also worth noting that eccrine sweat gland carcinomas may resemble carcinomas of the breast, bronchus, and kidney, making them difficult to differentiate from cutaneous neoplasms such as basaloid eccrine carcinoma [13].

In terms of specific characteristics, eccrine carcinoma (EC) is a rare carcinoma that originates from the eccrine sweat glands of the skin and accounts for less than 0.01% of diagnosed cutaneous malignancies [10]. It's also worth noting that eccrine spiradenoma, syringocystadenoma papilliferum, hidradenoma, and cylindroma represent less common benign sweat gland tumors, making up less than 0.1% of all specimens received [11].

Overall, the differential diagnosis of eccrine sweat gland cancer is complex and requires careful consideration of various other conditions that may present similarly to this type of cancer.

References: [4] - May 30, 2019 — Differential Diagnoses · Basal Cell Carcinoma · Cutaneous Squamous Cell Carcinoma · Dermatologic Manifestations of Merkel Cell Carcinoma. [5] - by J Awad · 2021 — The differential diagnoses of such lesions mainly include metastatic disease commonly from a primary breast, gastric, or bladder carcinoma, ... [7] - by K Idrissi Serhrouchni · 2013 · Cited by 17 — Other differential diagnoses comprise neoplasms with clear cell differentiation. These include trichilemmal carcinoma, clear cell BCC and clear ... [8] - Differential diagnosis: Squamoid eccrine ductal carcinoma may be mistaken for squamous cell carcinoma on superficial biopsies. Eccrine porocarcinoma may show ... [10] - Eccrine carcinoma (EC) is a rare carcinoma that originates from the eccrine sweat glands of the skin and accounts for less than 0.01% of diagnosed cutaneous malignancies [11]. [11] - Eccrine spiradenoma, syringocystadenoma papilliferum, hidradenoma, and cylindroma represent less common benign sweat gland tumors, making up less than 0.1% of all specimens received. [13] - Eccrine sweat glands are widely distributed almost everywhere in the skin. ... cytoplasm and prominent nuclei. Apoptotic cells, geographical necrosis and desmoplastic stroma are usually seen. The differential diagnosis of basaloid eccrine carcinoma is wide, and includes Merkel cell carcinoma, Ewing's sarcoma, metastatic carcinoma, as well as ... [14] - Clinically, eccrine carcinoma must be considered in the differential diagnosis of patients older than fifty years with long standing tumors in the limbs, including basal cell carcinoma (BCC), Paget’s disease, melanoma, metastatic cancer , inflammatory, lymphocytic and vascular lesions .