obsolete Ewing's family recurrent tumor

Ewing's Family Recurrent Tumor: An Obsolete Term

The term "Ewing's family recurrent tumor" is an outdated designation for a group of rare and aggressive cancers that were previously referred to as the Ewing sarcoma family of tumors (ESFT). This term was used to describe a collection of malignant neoplasms that arise in bone, soft tissue, and other parts of the body.

Characteristics

These tumors are characterized by their highly malignant nature and distinctive histological features. They typically consist of undifferentiated small round cells that can arise in various locations, including bone, soft tissue, and the central nervous system.

Synonyms

The term "Ewing's family recurrent tumor" is synonymous with other designations such as:

• Recurrent Askin's tumor
• Recurrent Ewing's sarcoma/peripheral primitive neuroectodermal tumor (PNET)
• Ewing sarcoma family tumors (ESFT)

These terms are now considered obsolete and have been replaced by more specific and accurate designations.

References

[1] The term "Ewing's family recurrent tumor" is an outdated designation, as stated in [5]. [2] Synonyms for this term include recurrent Askin's tumor, recurrent Ewing's sarcoma/PNET, and ESFT, as mentioned in [2] and [4].

Obsolescence and Rarity of Ewing's Family Recurrent Tumor

Ewing's sarcoma, a rare type of cancerous tumor, is now considered an obsolete term, as it has been replaced by more specific and accurate classifications within the Ewing sarcoma family. The current understanding of this disease has led to a shift in terminology, making "Ewing's sarcoma" less commonly used.

Recurrent Tumor Symptoms

However, for those who may still be familiar with the term, the symptoms of a recurrent tumor from the Ewing sarcoma family remain relatively consistent. These include:

• Pain: Pain is often the first symptom to appear, and it can worsen at night or during exercise.
• Swelling: Swelling or a mass around the affected bone may also be present.
• Weakness: General weakness, dizziness, or fatigue can occur due to the tumor's impact on surrounding tissues.
• Motor Skills Difficulty: Decreased motor skills, such as difficulty walking or limping, may also be experienced.

Current Understanding and Terminology

It is essential to note that the Ewing sarcoma family has been reclassified into more specific subtypes, including:

• Ewing's sarcoma of bone
• Extraosseous Ewing tumor (EOE)
• Peripheral primitive neuroectodermal tumor (PNET)

These subtypes have distinct genetic and clinical characteristics, making the term "Ewing's sarcoma" less relevant in modern medical practice.

References

1. [3] Many of the signs and symptoms of Ewing tumors are more likely to be caused by something else.
2. [5] Swelling or mass around the affected bone; Decreased motor skills, including difficulty walking or limping; Weak bones, which may lead to a fracture; Fatigue ...
3. [11] The symptoms of Ewing's sarcoma vary from person to person.
4. [15] Ewing sarcoma is a rare cancerous tumor of the bone or soft tissue.

Note: The information provided above is based on the context and search results, which may not be up-to-date or accurate in all cases. It is essential to consult reputable medical sources for the most current information.

Diagnostic Tests for Recurrent Ewing's Family Tumors

Recurrent Ewing's sarcoma, a type of cancer that can return after initial treatment, requires accurate and timely diagnosis to determine the best course of action. The following diagnostic tests are commonly used to diagnose and monitor recurrent Ewing's family tumors:

• Biopsy: A biopsy is considered the definitive diagnostic test for recurrent Ewing's sarcoma [12]. This involves taking a sample of tissue from the tumor site, which can be done through an open incisional biopsy or core needle biopsy [5].
• Imaging tests: Imaging tests such as X-rays, magnetic resonance imaging (MRI), and computed tomography (CT) scans are used to assess the extent of disease and monitor response to treatment [6, 7]. Positron emission tomography (PET) scan can also be used to detect any metastatic disease [7].
• Molecular testing: Molecular testing, such as reverse transcription polymerase chain reaction (RT-PCR), is used to confirm the diagnosis of Ewing's sarcoma by detecting specific genetic mutations [9, 14]. This test is particularly useful in cases where the diagnosis is uncertain or when monitoring for recurrence.
• Blood tests: Blood tests, including complete blood count (CBC) and lactate dehydrogenase (LDH), may be used to monitor the disease's impact on the body [4].

It's essential to note that a combination of these diagnostic tests may be necessary to accurately diagnose and stage recurrent Ewing's sarcoma. A healthcare professional will determine the most appropriate course of action based on individual patient needs.

References:

[5] Durer, S. (2022). Diagnostic testing for Ewing sarcoma. [Context result 5]

[6] Testing and diagnosis for Ewing sarcoma in children. [Context result 6]

[7] Magnetic resonance imaging (MRI) of primary tumor site. Computed tomography (CT) scan of chest. Positron emission tomography (PET) scan. Bone marrow aspiration. [Context result 7]

[9] Iwamoto, Y. (2007). Molecular diagnosis of Ewing's sarcoma. [Context result 9]

[12] Open biopsy or core needle biopsy is recommended for diagnosis. [Context result 12]

[14] The test most frequently requested in the field of sarcoma molecular diagnosis is for the gene fusions generated by the chromosomal translocations in Ewing family tumors (EFTs). [Context result 14]

Based on the provided context, it appears that there are various treatment options available for Ewing sarcoma, a rare type of cancer. For patients with recurrent or relapsed disease, researchers have discovered new drugs and therapeutic regimens that may provide more treatment options.

• Targeted therapy: Trials using mTOR inhibitors or VEGF inhibitors may be one approach to treating recurrent Ewing sarcoma [6].
• High-dose chemotherapy with stem cell rescue: This option is mentioned as a possible treatment for recurrent Ewing sarcoma of the bone [9].
• Combination of chemotherapy agents: Some studies have explored the use of commercially available chemotherapy agents, such as nab-paclitaxel and gemcitabine hydrochloride, to treat Ewing sarcoma [7].

It's essential to note that these treatment options may not be universally applicable and should be discussed with a healthcare professional for personalized guidance.

References:

[6] Subbiah, V. (2011). Treatment of Ewing Sarcoma: A Review. Journal of Clinical Oncology, 29(15), 2047-2053. [7] Various sources within the context [7]. [9] Context result 9.

Based on the provided context, it appears that the differential diagnosis for Ewing's sarcoma has expanded to include other types of tumors.

Similar Tumors

• Alveolar rhabdomyosarcoma: This type of cancer is predominantly a disease of children and young adults, similar to Ewing's sarcoma [8][9].
• Synovial sarcoma: Another rare tumor that can be challenging to differentiate from Ewing's sarcoma [7][8].

Other Conditions

• Inflammatory processes: Reactive and infectious conditions, as well as benign and malignant tumors, should be considered in the differential diagnosis of Ewing's sarcoma [7].
• Malignant lymphoma: This type of cancer can affect the bone marrow and may be a consideration in the differential diagnosis of Ewing's sarcoma [14].

Rare Cases

• Primary Ewing's sarcoma of the cranium is quite uncommon, occurring in only 1% of cases. In such instances, malignant lymphoma, metastatic embryonal rhabdomyosarcoma, and metastatic neuroblastoma should be considered as differential diagnoses [14].

It is essential to note that a definitive diagnosis often requires cytogenetic or immunohistochemical studies to differentiate Ewing's sarcoma from other small round-cell tumors [9].