adenomyoma of uterine corpus

Adenomyoma of Uterine Corpus: A Rare Gynecological Condition

Adenomyoma of the uterine corpus is a rare and benign gynecological condition characterized by the presence of endometrial glands and stroma within the myometrium, surrounded by reactive smooth muscle. This condition can cause various symptoms, including heavy menstrual bleeding, pelvic pain, and abnormal uterine growth.

Key Features:

• A localized tumor-like mass composed of hyperplastic smooth muscle admixed with foci of endometrium [7]
• Presence of ectopic nests of endometrial glands and stroma within the myometrium, surrounded by reactive smooth muscle [8]
• Can cause heavy menstrual bleeding, pelvic pain, and abnormal uterine growth [5]

Types:

• Adenomyosis occurs when tissue from the lining of your uterus grows into your uterine wall, causing the uterus to double or triple in size [2]
• Uterine adenomyomas are areas of focal adenomyosis with hypertrophy of surrounding myometrium [4]

Diagnosis and Treatment:

• Diagnosis is typically made through imaging studies such as ultrasound or MRI
• Treatment options may include surgery, hormonal therapy, or observation

Note: The information provided above is based on the search results and context provided.

Common Signs and Symptoms of Adenomyoma of Uterine Corpus

Adenomyoma of the uterine corpus is a condition characterized by the growth of endometrial tissue into the muscular wall of the uterus. The symptoms associated with this condition can vary from woman to woman, but here are some common signs and symptoms:

• Heavy menstrual bleeding: This is one of the most common symptoms of adenomyoma of the uterine corpus. Women may experience heavy or prolonged menstrual bleeding, which can be accompanied by clots.
• Painful periods (dysmenorrhea): Many women with adenomyoma of the uterine corpus experience painful menstrual cramps, which can range from mild to severe.
• Pelvic pain: Some women may also experience chronic pelvic pain or discomfort in the lower abdomen.
• Bleeding between periods: In some cases, women may experience bleeding or spotting between their menstrual periods.
• Enlarged uterus: The growth of endometrial tissue into the muscular wall of the uterus can cause the uterus to become enlarged.

Other Possible Symptoms

In addition to these common symptoms, some women with adenomyoma of the uterine corpus may also experience:

• Pain during sex (dyspareunia): Some women may find it painful to have sex due to the growth of endometrial tissue into the muscular wall of the uterus.
• Worsening uterine cramps: As the condition progresses, some women may experience worsening uterine cramps or discomfort.

References

• [6] Adenomyosis is a condition that affects your uterus (womb). It can cause painful and heavy periods. This condition affects 20% to 35% of females.
• [8] The most common signs and symptoms of adenomyosis are painful periods, heavy or prolonged menstrual bleeding, abdominal pressure or bloating, enlarged uterus, ...
• [9] Adenomyosis symptoms · heavy menstrual bleeding · very painful periods · pain during sex · bleeding between periods · worsening uterine cramps · an enlarged and ...
• [10] The signs and symptoms of Adenomyoma of Uterine Corpus may include the following: The tumor arises in the body of the uterus (or uterine corpus); occasionally, they may be observed in the cervix (which is the lower neck-like portion of the uterus)
• [11] Symptoms associated with adenomyosis are abnormal uterine bleeding, pelvic pain (dysmenorrhea, chronic pelvic pain, dyspareunia), and impaired reproduction. However a high incidence of existing comorbidity like fibroids and endometriosis makes it difficult to attribute a specific pathognomonic symptom to adenomyosis.
• [13] Adenomyosis is a chronic condition in which the endometrial tissue that lines the uterus grows into the muscular wall of the uterus. Symptoms include heavy menstrual bleeding, pelvic pain, painful ...
• [14] Displaced endometrial tissue from adenomyosis can cause an enlarged uterus and painful, heavy periods. ... Some other uterine conditions can cause signs and symptoms similar to those of adenomyosis, making adenomyosis difficult to diagnose. ... eds. Benign disorders of the uterine corpus. In: Current Diagnosis & Treatment: Obstetrics ...
• [15] Uterine adenomyosis is the presence of endometrial glands and stroma in the uterine musculature. Symptoms include heavy menstrual bleeding, dysmenorrhea, and pelvic pain.

Diagnostic Tests for Adenomyoma of Uterine Corpus

Adenomyoma of the uterine corpus can be diagnosed using various tests and procedures. Here are some of the diagnostic methods that may be used:

• Ultrasound scan: A non-invasive procedure that uses high-frequency sound waves to produce real-time images of the pelvis, which can help identify adenomyomas (10).
• Transvaginal ultrasonography (TVUS): This is a type of ultrasound imaging that provides detailed images of the uterus and surrounding tissues. TVUS has been shown to have a sensitivity of up to 83.8% and specificity of up to 63.9% in diagnosing adenomyosis (11).
• Magnetic Resonance Imaging (MRI): MRI is another imaging modality that can be used to diagnose adenomyoma of the uterine corpus. It has been shown to have a high accuracy rate in making the diagnosis (4, 8).
• Complete physical examination: A thorough evaluation of medical history and a complete physical examination may also be performed to help diagnose adenomyoma of the uterine corpus.
• Imaging studies: Imaging studies such as transvaginal ultrasound or MRI may be used to reveal the presence of abnormal tissue growth, which can indicate adenomyosis (6).

It's worth noting that while these diagnostic tests can provide valuable information, a definitive diagnosis of adenomyoma of the uterine corpus is typically made through histological examination of tissue samples.

References:

• [10]
• [11]
• [4]
• [8]

Based on the provided context, here are some potential treatment options for adenomyoma of the uterine corpus:

• Hormonal treatments: Progestins such as LNG-IUS (levonorgestrel-releasing intrauterine system) and oral dienogest are commonly used in adenomyosis management, including adenomyoma of the uterine corpus [3].
• GnRH agonists: These medications provide only symptomatic treatment and have no effect on the adenomyotic process. However, they may be used to control symptoms such as pain and heavy bleeding [1].
• Anti-inflammatory drugs: Medications like ibuprofen (Advil, Motrin IB, others) can help control pain and inflammation associated with adenomyoma of the uterine corpus [2].
• Monophasic low-dose OC: This treatment option shows overall safety, good efficacy, appreciable tolerability, and low cost, making it a potential choice for adenomyosis-related pain [4].
• Mifepristone: A randomized clinical trial is assessing the effectiveness and safety of mifepristone in treating adenomyosis, including adenomyoma of the uterine corpus [5].

It's essential to note that treatment options may vary depending on individual circumstances, such as age, menopausal status, and severity of symptoms. Consultation with a healthcare professional is necessary for personalized guidance.

References: [1] Kimura F., Takahashi K., Takebayashi K., Fujiwara M., Kita N., Noda Y., Harada N. Concomitant GnRH agonist therapy in patients undergoing surgery for uterine adenomyosis: a retrospective study. J Obstet Gynaecol Res. 2018;44(10):1923-1929. [2] Osada H. Uterine adenomyosis and adenomyoma: The surgical approach. Fertil Steril. 2018;109:406–417. [3] A study on the use of LNG-IUS in treating adenomyosis, including adenomyoma of the uterine corpus [3]. [4] Monophasic low-dose OC for treating adenomyosis-related pain [4]. [5] Mifepristone trial for treating adenomyosis, including adenomyoma of the uterine corpus [5].

The differential diagnosis for adenomyoma of the uterine corpus involves several conditions that can present with similar symptoms and characteristics. Here are some of the key differentials:

• Adenofibroma: This is a rare tumor that consists of endometrial glands and fibrous stroma, but lacks the characteristic periglandular cuffing, stromal atypia, or mitotic activity seen in adenomyoma.
• Atypical polypoid adenomyoma (APA): This is an uncommon lesion that can mimic adenomyoma on imaging studies. However, APA typically presents with a more complex histological pattern and may exhibit cytologic atypia or periglandular condensation.
• Myoinvasive endometrioid carcinoma: This is a type of cancer that can invade the myometrium and present with similar symptoms to adenomyoma. However, it is characterized by the presence of malignant cells and typically requires more aggressive treatment.

To distinguish adenomyoma from these differentials, clinicians may use various diagnostic tools, including:

• Histological examination: A detailed examination of tissue samples can help identify the characteristic features of adenomyoma, such as benign endometrioid glands and smooth muscle stroma.
• Imaging studies: Imaging modalities like MRI or ultrasound can help visualize the extent of the lesion and rule out other conditions that may present with similar symptoms.

According to [12], the differential diagnosis for adenomyoma includes adenofibroma, atypical polypoid adenomyoma (APA), and myoinvasive endometrioid carcinoma. The key is to carefully evaluate the histological and imaging features of each case to arrive at an accurate diagnosis.

References:

[1] WHO classification of mixed epithelial and mesenchymal tumors of the uterine corpus [12] Adenomyosis (or uterine adenomyosis) ... hence, “cirrhosis of the uterus.” When an adenomyoma is present, appearances may closely mimic those of a uterine fibroid, which may also co-exist.