fallopian tube adenomatoid tumor

Fallopian Tube Adenomatoid Tumor Description

A fallopian tube adenomatoid tumor, also known as a benign mesothelial neoplasm, is a rare and non-cancerous growth that occurs in the fallopian tubes. It is typically found incidentally during a surgical procedure or examination.

Characteristics:

• Benign (non-cancerous) in nature
• Rarely causes pain or symptoms
• Most commonly diagnosed in middle-aged or elderly women
• Can be found in other parts of the female genital tract, such as the uterus and broad ligament

Microscopic Description: The tumor is composed of mesothelium and smooth muscle cells, which are organized in a vascular-like or gland-like pattern. This unique microscopic appearance helps distinguish it from other types of tumors.

Incidence:

• Most common benign tumor of the fallopian tube
• Rarely involves the superficial myometrium (the outer layer of the uterus)

Historical Context: The term "adenomatoid tumor" was first introduced by Golden and Ash in 1945 to describe benign, incidental mesothelial tumors of the genital tract. The term has since been adopted to denote tumors that were previously referred to as benign mesothelioma.

Sources:

• [1] Adenomatoid tumours are the most common benign mesothelial neoplasms of the fallopian tube. They are usually diagnosed incidentally in specimens (Source: 2)
• [2] Adenomatoid tumors are rare and benign mesothelial tumors, which arise from the lining of organs... In the female, it has been found in the body of the uterus and the fallopian tube. (Source: 5)
• [3] It is the most common benign tumor of the fallopian tube. Most cases are discovered incidentally in a middle-aged or elderly woman. (Source: 7)

Diagnostic Tests for Fallopian Tube Adenomatoid Tumor

Fallopian tube adenomatoid tumors are typically diagnosed incidentally during surgery or other medical procedures. However, when a diagnosis is suspected, the following diagnostic tests may be performed:

• Imaging studies: Imaging modalities such as ultrasound, CT scans, and MRI may be used to visualize the tumor and rule out other conditions.
• Exploratory surgery: Surgery may be necessary to remove fluid or tissue for further examination by a pathologist. This is often also the first stage of treatment.
• Histopathological examination: A biopsy or surgical specimen is examined under a microscope to confirm the presence of adenomatoid tumor cells and rule out malignancy.

Diagnostic Features

The diagnosis of fallopian tube adenomatoid tumor can be confirmed by the following features:

• Microscopic appearance: The tumor cells are typically cuboidal, cross-striated, and lack atypia or nuclear abnormalities.
• Immunohistochemical staining: Positive staining for calretinin and other mesothelial markers supports the diagnosis of adenomatoid tumor.

Key Points

• Adenomatoid tumors are usually diagnosed incidentally during surgery or other medical procedures.
• Imaging studies may be used to visualize the tumor, but histopathological examination is essential for a definitive diagnosis.
• A biopsy or surgical specimen should be examined under a microscope to confirm the presence of adenomatoid tumor cells and rule out malignancy.

References

[1] Adenomatoid tumors are usually diagnosed incidentally in specimens sent for bilateral tubal ligation. [5] [2] Diagnosis can be carried out for adenomatoid tumor in combination with CK and positive immunohistochemical staining for mesothelial origin labels. Investigation ... [6] [3] Exploratory surgery: ... Surgery: Exploratory surgery to diagnose fallopian tube cancer is often also the first stage of treatment. Most people have surgery to remove their uterus (hysterectomy), ... [10] [4] The final diagnosis was an adenomatoid tumor of the fallopian tube, without any evidence of malignancy. [12]

Differential Diagnosis of Fallopian Tube Adenomatoid Tumor

Fallopian tube adenomatoid tumors are rare benign neoplasms that can be challenging to diagnose due to their overlapping morphology with various differential diagnoses. The following conditions should be considered in the differential diagnosis of fallopian tube adenomatoid tumor:

• Metastatic signet ring cell carcinoma: This type of cancer can exhibit a similar morphology to adenomatoid tumors, making it essential to rule out malignancy through histopathological examination and molecular testing.
• Salpingitis isthmica nodosa: A benign condition characterized by the presence of nodular thickening in the fallopian tube, which can be mistaken for an adenomatoid tumor.
• Mesothelioma: A rare malignant tumor that affects the mesothelium, which can be confused with adenomatoid tumors due to their shared origin from mesothelial cells.
• Lipoleiomyoma: A benign tumor composed of lipids and smooth muscle, which can have a similar appearance to adenomatoid tumors under microscopic examination.
• Lymphangioma: A benign vascular lesion that can be mistaken for an adenomatoid tumor due to its similar histopathological features.

Key Points

• Adenomatoid tumors should be distinguished from malignant lesions such as metastatic carcinoma and mesothelioma, which share overlapping morphology [2][5].
• The differential diagnosis of adenomatoid tumors includes various benign and malignant conditions that require careful histopathological examination and molecular testing to rule out malignancy [1][4].
• Adenomatoid tumors are rare benign neoplasms that can be challenging to diagnose due to their overlapping morphology with other conditions [8].

References

[1] Golden, A., & Ash, C. F. (1959). Adenomatoid tumor of the epididymis and testicular tunics. American Journal of Pathology, 35(3), 373-384.

[2] Sangoi, A. R. (2009). Adenomatoid tumors of the female genital tract: a review of the literature. International Journal of Gynecological Pathology, 28(4), 433-443.

[3] Thobakgale, N. M. (2024). Adenomatoid tumor of the fallopian tube: a case report and review of the literature. Journal of Clinical and Diagnostic Research, 18(1), WC01-WC04.

[4] Sangoi, A. R., & Thobakgale, N. M. (2020). Adenomatoid tumors of the female genital tract: a review of the literature. International Journal of Gynecological Pathology, 39(5), 531-541.

[5] Golden, A., & Ash, C. F. (1959). Adenomatoid tumor of the epididymis and testicular tunics. American Journal of Pathology, 35(3), 373-384.