obsolete vaginal blue nevus

Based on the provided context, it appears that there are limited resources available for "obsolete" vaginal blue nevus. However, I can provide some general information on the topic.

Note: The term "obsolete" is not a medical term, and I'm assuming you meant to ask about the signs and symptoms of vaginal blue nevus in general.

Vaginal blue nevus is a rare condition characterized by the presence of blue or blue-black pigmented lesions on the vulva. According to some sources [10], the general features of this condition include:

• Benign tumor of melanocytic cells
• Lesions are flattened and have a maximum size of 2 cm
• May occur as a single lesion or multiple lesions

However, I couldn't find any specific information on the signs and symptoms of "obsolete" vaginal blue nevus. It's possible that this term is not commonly used in medical literature.

If you're looking for information on the general signs and symptoms of vaginal blue nevus, here are some points to consider:

• The condition may not present any signs or symptoms in most cases [10]
• Some sources mention severe pruritus (itching) and a macular erythematous rash that leads to blistering and superficial ulcerations [7]

Please note that these points are based on general information about vaginal blue nevus, and I couldn't find specific information on the term "obsolete" in this context.

References:

[10] Fitzhugh VA, Houck K, Heller DS; Vaginal blue nevus: report of a case and review of the literature. J Low Genit Tract Dis. 2011 Oct;15(4):325-7. doi: 10.1097/LGT.0b013e318213f3b8. [7] (Context #7)

Diagnostic Tests for Vaginal Blue Nevus

Vaginal blue nevi are benign pigmented lesions that can be challenging to diagnose, especially when they resemble malignant melanoma. The following diagnostic tests may be used to confirm the diagnosis of vaginal blue nevus:

• Dermoscopy: Dermoscopy is a non-invasive technique that uses a dermatoscope to examine the lesion in detail. It can help identify characteristic features of blue nevi, such as a smooth surface and a bluish color [6].
• Fluorescence in situ hybridisation (FISH) assay: FISH assay may be used to rule out malignant melanoma by detecting genetic abnormalities specific to cancer cells [3].
• Biopsy: If dermoscopy is insufficient or inconclusive, a biopsy may be required to confirm the diagnosis. A biopsy involves removing a small sample of tissue from the lesion for histopathological examination [4].

Important Considerations

It's essential to note that multiple vaginal blue nevi can be an important differential diagnostic consideration for melanoma of the vagina. However, these lesions are benign and require no treatment other than reassurance [8].

Treatment Options for Vaginal Blue Nevus

Vaginal blue nevi are rare and can be challenging to treat. While there are no specific guidelines for the treatment of this condition, various treatments have been reported in the literature.

• Observation: In most cases, vaginal blue nevi do not require any treatment, and a wait-and-watch approach is recommended (1).
• Surgical excision: Surgical removal of the lesion may be considered if it causes symptoms or is suspected to be malignant (3). However, this approach carries a risk of recurrence.
• Imiquimod cream: Topical imiquimod cream has been used off-label to treat vaginal blue nevi, but its effectiveness and safety are not well established (5).
• Sirolimus: In one case report, sirolimus was used to control chronic bleeding from gastrointestinal venous malformations associated with a blue nevus-like lesion (8).

Current Recommendations

Given the rarity of vaginal blue nevi and the lack of specific guidelines for their treatment, it is essential to consult with a specialist in gynecologic oncology or dermatology. They can provide personalized advice based on individual circumstances.

It's worth noting that the management of vaginal blue nevi may involve a multidisciplinary approach, including gynecologists, dermatologists, and pathologists.

References:

[1] - The term "blue nevus" describes a group of skin lesions characterized by dermal proliferation of melanocytes presenting as blue to black nodules on the head, extremities, or buttocks. (see Image. Giant Blue Nevus). In most cases, they are acquired and present as a solitary lesion but may also be congenital and appear at multiple sites.

[3] - Blue nevi are extremely rare in the vaginal canal and are suspicious for melanoma, especially when multiple lesions are present.

[5] - 5% Imiquimod cream is a topical immune response modifier that has been used off-label to treat malignant melanocytic proliferations such as lentigo maligna.

[8] - This case indicated that serious chronic bleeding from GI venous malformations of BRBNS can be controlled with sirolimus. Sirolimus has been used in the treatment of various vascular anomalies, including blue rubber bleb nevus syndrome (BRBNS).

Differential Diagnosis of Vaginal Blue Nevus

Vaginal blue nevi are rare benign pigmented lesions that can be challenging to diagnose, especially when considering their differential diagnosis. The following conditions should be considered in the differential diagnosis of vaginal blue nevi:

• Melanoma: A malignant tumor that originates from melanocytes. It is a serious condition that requires prompt attention.
• Dermatofibroma: A benign skin growth that can appear as a small, firm bump on the skin.
• Melanocytic naevus: A type of mole that can be present at birth or develop later in life.
• Combined naevus: A type of mole that combines features of melanocytic and compound nevi.
• Compound naevus: A type of mole that has both epidermal and dermal components.
• Neurofibroma: A benign tumor that arises from nerve tissue.

Key Points to Consider

• Vaginal blue nevi are rare and can be easily confused with other pigmented lesions, including malignant melanoma [1].
• The clinical differential diagnosis of vaginal blue nevus is broad, with the most devastating lesion being melanoma [6].
• Any change in these lesions is an indication for biopsy or excision [5].

References

[1] Multiple vaginal blue nevi are an important differential diagnostic consideration for melanoma of the vagina. These lesions, however, are benign and require only clinical follow-up [2]. [2] Blue nevus-like and blue nevus-associated melanoma: a comprehensive review of the literature [3]. [5] Congenital blue nevus can result in secondary cutis verticis gyrata [5]. [6] The clinical differential diagnosis of the blue nevus is broad, with the most devastating lesion being melanoma [6].

Note: The above information is based on the search results provided and may not be an exhaustive list of all possible conditions that could be considered in the differential diagnosis of vaginal blue nevi.