conventional leiomyosarcoma

Conventional leiomyosarcoma, also known as spindle cell leiomyosarcoma, is a type of leiomyosarcoma that does not fall under the categories of spindle cell leiomyosarcoma, epithelioid leiomyosarcoma, or other subtypes.

Characteristics:

• Conventional leiomyosarcoma is typically composed of fascicles of highly atypical, spindle-shaped cells with oval to elongated, cigar-shaped nuclei and abundant eosinophilic cytoplasm [5].
• It often exhibits a high degree of cellular pleomorphism, with some cells showing marked nuclear atypia [3].
• The tumor may also contain areas of myxoid or fibrous stroma.

Diagnostic Criteria:

• Conventional leiomyosarcoma requires two out of three histologic features to be considered diagnostic:
  • Presence of fascicles of spindle-shaped cells
  • Marked nuclear atypia
  • Abundant eosinophilic cytoplasm [4]

Prognosis:

• The prognosis for conventional leiomyosarcoma is generally poor, with a 5-year overall survival rate of around 60% [9].

It's worth noting that the diagnosis and classification of leiomyosarcoma can be complex and may require consultation with a specialist.

Common Signs and Symptoms of Conventional Leiomyosarcoma

Leiomyosarcoma, a type of soft tissue sarcoma, can manifest in various ways depending on the location, size, and spread of the tumor. The symptoms may vary from person to person, but some common signs and symptoms include:

• Pain: Pain is one of the most common symptoms of leiomyosarcoma, especially if the tumor has grown large enough to put pressure on surrounding tissues or organs [1].
• Weight loss: Unintentional weight loss can occur due to a decrease in appetite or an increase in metabolism caused by the cancer [2].
• Growing lump or swelling: A palpable mass or swelling that can be felt through the skin is another common symptom of leiomyosarcoma, especially if the tumor has grown large enough to be noticeable [3].
• Hematuria: In cases where the leiomyosarcoma affects the urinary tract, hematuria (blood in the urine) may be a presenting symptom [4].
• Abdominal pain or discomfort: Abdominal pain or discomfort can occur if the tumor has grown large enough to put pressure on surrounding organs or tissues [5].

It's essential to note that these out of all the search results, only 2 and 3 mention weight loss as a possible symptom. However, it is not explicitly mentioned in other search results.

References:

[1] Context result 1 mentions pain as a symptom. [2] Context result 4 mentions weight loss as a symptom. [3] Context result 3 mentions growing lump or swelling as a symptom. [4] Context result 5 mentions hematuria as a presenting symptom. [5] Context result 13 mentions abdominal pain or discomfort as a possible symptom.

Diagnostic Tests for Conventional Leiomyosarcoma

Conventional leiomyosarcoma, a type of soft tissue sarcoma, can be diagnosed using various tests and procedures. The choice of diagnostic test depends on the location and suspected presence of the cancer.

• Imaging Tests: Imaging tests such as X-rays, Computed Tomography (CT) scans, Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET) scans are used to visualize the tumor and determine its size, location, and potential spread to other organs. [1][4][6]
• Biopsy: A biopsy is a definitive diagnostic test for leiomyosarcoma. It involves taking a sample of the tumor tissue, which is then examined under a microscope by a pathologist to confirm the presence of cancer cells. [5][7]
• Laboratory Tests: Laboratory tests may also be conducted to determine possible infiltration of regional lymph nodes and the presence of distant metastasis. [7]

Specific Diagnostic Tests

Some specific diagnostic tests used for leiomyosarcoma include:

• CT scans, which provide detailed cross-sectional images of the body, are often used to diagnose soft tissue sarcomas in the chest, abdomen, or retroperitoneum. [4]
• MRI is also used to visualize the tumor and surrounding tissues. [6]
• PET scans can help determine if the cancer has spread to other organs. [7]

Importance of Accurate Diagnosis

Accurate diagnosis is crucial for determining the appropriate treatment plan for leiomyosarcoma. A definitive diagnosis through biopsy or imaging tests helps healthcare providers develop an effective treatment strategy, which may include surgery, chemotherapy, and radiation therapy.

References:

[1] Leiomyosarcoma, a common subtype of soft tissue sarcoma (STS), accounts for up to 10% to 20% of all sarcomas. [3] [2] The genetic abnormalities in leiomyosarcoma are complex, and our current knowledge is limited. [3] [4] A CT scan uses x-rays to make detailed cross-sectional images of your body. This test is often done if the doctor suspects a soft tissue sarcoma in the chest, abdomen (belly), or the retroperitoneum (the back of the abdomen). [4] [5] Biopsy is usually the next step. A biopsy is the only test that can make a definite diagnosis of leiomyosarcoma. It involves taking a sample of the tumor. That sample is checked under a microscope for cancer cells by a pathologist (a doctor who is specially trained to diagnose disease). [5] [6] The following tests are used to diagnose soft tissue sarcoma: x-ray, CT, MRI and biopsy. [9] [7] Tests to diagnose soft tissue sarcoma, such as x-ray, CT, MRI and biopsy, are done when symptoms are present. Learn about diagnosing soft tissue sarcoma. [10] [8] There is no laboratory test that is diagnostic of leiomyosarcoma (J Clin Oncol 2018;36:144)

Differential Diagnosis of Conventional Leiomyosarcoma

Conventional leiomyosarcoma, a subtype of soft