obsolete pure BAC

Bronchioloalveolar Carcinoma (BAC) - Obsolete Pure Definition

The term Bronchioloalveolar Carcinoma (BAC) was previously used to describe a specific type of lung cancer. According to medical literature, BAC was strictly defined as a noninvasive tumor with a pure lepidic growth pattern [3]. This means that it grew along the alveoli and bronchioles without invading surrounding tissues.

In this context, BAC referred to adenocarcinomas with a specific growth pattern, characterized by:

• Pure lepidic growth: The cancer cells spread along the alveolar walls and bronchiolar surfaces.
• No evidence of stromal, vascular, or pleural invasion: The tumor did not invade surrounding tissues, such as blood vessels, nerves, or the pleura (the lining surrounding the lungs).

However, due to its narrow definition, most literature on BAC has become obsolete [5]. This is because many studies reported on adenocarcinomas with mixed subtypes that included a BAC component. As a result, the term BAC is no longer used in modern medical practice.

References: [3] Sakurai H (2014) - Cited by 35 [5] Brambilla E (2007) - Cited by 1

Based on the search results, it appears that you are looking for information on the signs and symptoms of obsolete pure Blood Alcohol Concentration (BAC). However, I must note that the concept of "obsolete" BAC is not clearly defined in the provided context.

That being said, I will attempt to provide an answer based on the available information. It seems that the context provides information on various BAC levels and their corresponding symptoms, but it does not specifically mention "obsolete" BAC.

However, I can try to summarize the information related to high BAC levels, which might be considered as obsolete or no longer relevant in modern times:

• A BAC of 0.40% or higher is considered potentially lethal, with risks of coma or alcohol overdose death [14].
• At this level, there's a risk of coma or alcohol overdose death [14].

Please note that these symptoms are associated with high BAC levels and might not be directly related to "obsolete" BAC.

If you could provide more context or clarify what you mean by "obsolete pure BAC," I would be happy to try again.

Based on the provided context, it appears that there are several diagnostic tests associated with the now-defunct term "pure" Bronchoalveolar Carcinoma (BAC). Here's a summary of the relevant information:

• Histologic examination: The diagnosis of "pure" BAC requires a histologic specimen from the lung [5]. This means that a biopsy or surgical excision of the tumor is necessary to confirm the presence of pure BAC.
• Biopsy limitations: Due to the definition of BAC requiring no evidence of invasive components within the entire nodule, BAC cannot be diagnosed based on small biopsied specimens [10].
• Molecular testing: Molecular testing can be used to confirm the presence of BAC, but it is not a standalone diagnostic test for pure BAC [1].

It's worth noting that the term "pure" BAC has been replaced by more specific and accurate diagnoses such as adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive adenocarcinoma of the lung [4].

The differential diagnosis of obsolete pure Bronchioloalveolar Carcinoma (BAC) involves considering various conditions that may present similarly to this type of lung cancer.

• Chronic alveolar opacity: This condition can mimic the appearance of a ground-glass nodule on imaging, making it a potential differential diagnosis for BAC.
• Solitary pulmonary nodule: A solitary pulmonary nodule can be a benign or malignant lesion that may resemble a pure BAC in terms of its radiographic appearance.
• Ground glass opacity: Ground glass opacity is a term used to describe a hazy or cloudy appearance on imaging, which can be seen in various lung conditions, including BAC.

According to search result [7], the differential diagnosis for subsolid nodules (which includes pure BAC) ranges from infection and focal interstitial fibrosis to malignant lung adenocarcinoma. This highlights the importance of careful evaluation and consideration of multiple differentials when diagnosing these types of lesions.

In addition, search result [12] notes that the differential diagnosis for BAC includes various conditions, such as centrilobular nodules and remote areas of ground-glass attenuation. This further emphasizes the need for a comprehensive approach to differential diagnosis in this context.

It's worth noting that pure BAC has been reclassified as an obsolete term, and its classification strategy has been modified based on a multidisciplinary approach to the diagnosis of lung adenocarcinoma (search result [4]). However, the principles of differential diagnosis remain relevant for evaluating similar lesions.