cervical adenofibroma

Cervical Adenofibroma: A Rare Benign Tumor

Cervical adenofibroma is a rare benign tumor that occurs in the cervix, which is the lower part of the uterus. It is a type of mixed epithelial and mesenchymal tumor, meaning it contains both glandular and fibrous tissues.

Characteristics:

• Cervical adenofibroma is a biphasic tumor, consisting of glands scattered in a mesenchymal stroma [8].
• The glandular component resembles proliferative endometrium [5][8].
• It is a benign tumor, meaning it does not have the potential to become cancerous.
• Cervical adenofibroma can occur at any age, but it is most commonly found in perimenopausal women [11].

Symptoms:

• Abnormal vaginal bleeding is the most frequent complaint associated with cervical adenofibroma [2][3].
• In some cases, the tumor may not cause any symptoms and may be detected incidentally during a routine gynecologic examination [13][14].

Diagnosis:

• Cervical adenofibroma can be diagnosed through a combination of clinical evaluation, imaging studies (such as ultrasound), and histopathological examination.
• A biopsy or surgical excision of the tumor is often necessary to confirm the diagnosis.

Treatment:

• The treatment for cervical adenofibroma typically involves surgical removal of the tumor.
• In some cases, additional treatments such as hormone therapy may be recommended.

References:

[1] Abell in 1971 - first reported cervical adenofibroma [11] [2] Most tumors arise in the endometrium [11] [3] Abnormal vaginal bleeding is a common symptom [11] [5] Glandular component resembles proliferative endometrium [8] [8] Cervical adenofibroma is a biphasic tumor [8] [11] Cervical adenofibroma can occur at any age, but it is most commonly found in perimenopausal women [11] [13] Tumor may not cause symptoms and may be detected incidentally [13] [14] Cervical adenofibroma can also occur in extrauterine sites [14]

Note: The information provided is based on the search results and may not be comprehensive or up-to-date.

Common Signs and Symptoms of Cervical Adenofibroma

Cervical adenofibroma, a rare type of tumor, can present with various symptoms in women. The most common signs and symptoms include:

• Abnormal Vaginal Bleeding: This is the most frequent presenting symptom, which can occur at any age but is more commonly seen in perimenopausal women [3][4][5].
• Dysuria and Urgency: Symptoms related to the size and exact location of the tumor can cause discomfort during urination and a sense of urgency [7].
• Obstruction of the Cervix: In some cases, the tumor can obstruct the cervix, leading to complications [7].
• Dyspareunia: Painful intercourse can also be a symptom, depending on the size and location of the tumor [7].

It's essential for women to report any unexplained bleeding or symptoms to their healthcare provider, as they can be indicative of various issues, including cervical adenofibroma.

References:

[1] by R Maciel · 2013 · Cited by 9 — When this tumor arises in the cervix, women can present with abnormal vaginal bleeding, as a first sign. It can occur in any age but is most commonly seen in ...

[2] by A Karaer · 2008 · Cited by 1 — The most common presenting symptom is abnormal vaginal bleeding. Some patients have a history of prior removal of polyps or a history of tamoxifen therapy ...

[3] by R Maciel · 2013 · Cited by 9 — When this tumor arises in the cervix, women can present with abnormal vaginal bleeding, as a first sign. It can occur in any age but is most ...

[4] by BB Li · 2022 · Cited by 2 — When this tumour occurs in the cervix, it usually presents first with abnormal vaginal bleeding. ... It can occur at any age, but it is most ...

[5] by A Haberal · 2005 · Cited by 23 — Adenofibromas can be seen in patients of any age, but they occur most frequently in peri- or postmenopausal women. Abnormal vaginal bleeding is ...

[7] Symptoms relate to its size and exact location: dysuria, urgency, obstruction of the cervix and dyspareunia.

Note: The above information is based on the search results provided within the context.

Cervical adenofibroma, a rare benign tumor, can be challenging to diagnose due to its rarity and similarity in appearance to other pathologies. However, several diagnostic tests can help confirm the diagnosis.

• Histological examination: A biopsy sample is essential for diagnosing cervical adenofibroma. Histopathological findings of the cervical biopsy specimen confirmed the diagnosis of cervical adenofibroma in one reported case [3]. The histological examination should reveal a biphasic neoplasm composed of glandular and fibrous tissues, as described in another study [14].
• Immunohistochemistry: Immunohistochemical analysis can aid in differentiating adenofibroma from other tumors. A combination of mitotic activity and nuclear atypia under histopathological examination combined with immunohistochemistry is recommended for accurate diagnosis [6].
• Transvaginal sonography: Transvaginal sonography may be used to visualize the cervical mass, as seen in one reported case where a cervical mass containing multiple irregular cysts was identified using this imaging modality [8].

It's essential to note that differential diagnoses should include other pathologies such as adenosarcoma, polyps, and endocervical adenocarcinoma. A careful evaluation of the biopsy sample is crucial for accurate diagnosis.

References: [3] - Cervical Adenofibroma; cervical adenofibroma ... MeSH; C Clinical test, ... [6] - by L Chen · 2024 — Therefore, a careful evaluation of mitotic activity and nuclear atypia under histopathological examination combined with immunohistochemistry is recommended for accurate diagnosis. [8] - The total surgery assured complete excision and permitted adequate sampling to exclude malignancy.

Based on the provided context, it appears that there are limited information available on the drug treatment of cervical adenofibroma.

However, I can provide some general information on the topic. Cervical adenofibroma is a rare type of tumor that typically affects the cervix and uterus. The main treatment options for this condition are surgical, including local tumor resection and total hysterectomy [5][9].

Regarding drug treatment, there is limited information available in the provided context. However, I can suggest some possible treatments that may be considered on a case-by-case basis.

• Chemotherapy: This type of treatment uses medications to kill cancer cells. While chemotherapy is not specifically mentioned as a treatment for cervical adenofibroma, it may be considered in certain cases where the tumor has spread or recurred.
• Targeted therapy: Targeted therapies are medications that target specific molecules involved in cancer growth and progression. There is no information available in the provided context on targeted therapies being used to treat cervical adenofibroma.

It's worth noting that the treatment of cervical adenofibroma typically involves surgical removal of the tumor, rather than drug treatment [5][9]. However, further research may be needed to determine the most effective treatment options for this condition.

References:

[5] by L Chen · 2024 — The main treatment method of cervical adenofibroma is surgical treatment including local tumor resection and total hysterectomy. Hysterectomy ...

[9] by HM Navada · Cited by 6 — Total hysterectomy is the preferred treatment for an adenofibroma because the neoplasm may recur if it is incompletely curetted or excised [10].