obsolete localized lymphoma

Based on your query, I will provide an informative response using the context provided.

Obsolete Localized Lymphoma

Localized lymphoma refers to a type of non-Hodgkin lymphoma (NHL) that is confined to a specific area or region of the body. This condition was previously

Based on the provided context, here are some signs and symptoms associated with localized lymphoma:

• Painless swelling of lymph nodes: This is often one of the first noticeable symptoms of lymphoma, particularly in the armpit, groin, and side of the neck [15].
• Solid mass in the abdomen: Abdominal NHL can present as a solid mass that causes abdominal pain due to compression or infiltration of nerves and its surrounding tissues [2].
• Facial pain, hearing loss, vertigo, proptosis, or visual disturbances: These symptoms are associated with lymphoma involving the base of the skull or CNS [1].

It's essential to note that these symptoms can also be indicative of other conditions. A proper diagnosis by a healthcare professional is necessary for an accurate assessment.

References:

[1] Mar 5, 2024 — Lymphoma involving the base of the skull or CNS can cause cranial nerve palsies, facial pain, hearing loss, vertigo, proptosis, or visual disturbances. [2] by C Fulignati · 2005 · Cited by 15 — Abdominal NHL typically present themselves as a solid mass and they cause abdominal pain due to compression or infiltration of nerves and its surrounding tissues. [15] The most common early symptom of lymphoma is inflammation or swelling in at least one lymph node. Lymphoma-related lymph node swelling is more common in the armpit, groin, and side of the neck.

Based on the provided context, it appears that diagnostic tests for localized lymphoma have evolved over time. Here are some key points related to diagnostic tests for obsolete localized lymphoma:

• Imaging tests: In the past, imaging tests such as CT scans and MRI were used to diagnose and stage lymphoma. However, these tests may not be as effective in detecting early-stage or localized lymphoma.
• Biopsy: Biopsy was considered essential to establish a diagnosis of lymphoma. Excisional biopsy (or core biopsy) of an affected lymph node was often performed to confirm the presence of lymphoma cells.
• Blood and urine testing: Blood, urine, and bone marrow testing may have been used in conjunction with imaging tests to aid in diagnosis.

However, it's essential to note that these diagnostic methods are not as relevant today due to advancements in medical technology and understanding of lymphoma. Modern diagnostic approaches prioritize more accurate and sensitive techniques, such as:

• 18F-FDG PET/CT: This imaging test has become the primary method for assessing treatment response in most lymphoma patients according to the Lugano Classification.
• Immunophenotype studies: These studies are now considered essential for diagnosing non-Hodgkin lymphoma, particularly B-cell lymphoma.

It's also worth noting that the diagnostic workup of lymphoma continues to evolve rapidly, and new clinicopathologic entities and techniques are being added to differentiate them. As a result, the optimal approach to diagnosis can be elusive, even in community-based and academic practice.

References:

• [3] In the last decade, some evidence accumulated to show the value of 18F-FDG PET/CT in staging and monitoring treatment response in patients with both HL and NHL.
• [5] At present, 18F-FDG PET-CT has become the primary method for assessing treatment response in most lymphoma patients according to the Lugano Classification.
• [4] The NCCN guidelines list immunophenotype studies as essential for diagnosis of non-Hodgkin lymphoma: For B-cell lymphoma, an immunophenotyping study is required.
• [10] The importance of all diagnostic tests, in tandem, yield the correct diagnosis.

Based on the provided context, it appears that there are various treatment options available for localized lymphoma.

First-line treatments

• According to search result [3], standard first-line therapy still consists of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or a CHOP-like regimen.
• Search result [4] mentions that bendamustine plus rituximab has demonstrated efficacy for the first-line treatment of advanced follicular, indolent, and mantle cell lymphomas.

Alternative treatments

• Search result [5] states that three ADCs (antibody-drug conjugates), brentuximab vedotin, polatuzumab vedotine, and loncastuximab tesirine, have been approved and are already establishing their place in lymphoma treatment.
• Search result [6] mentions that ibritumomab has shown efficacy in the treatment of refractory non-Hodgkin lymphoma and as a consolidation regimen.

Historical treatments

• Search result [7] from 2002 states that chemotherapy with the CHOP regimen is a highly effective treatment for localized lymphoma.
• Search result [10] mentions that Dave Coulier, an actor, underwent six planned chemotherapy treatments for stage 3 non-Hodgkin lymphoma.

Current standards of care

• Search result [9] from 2022 states that the current frontline standard of care for DLBCL (diffuse large B-cell lymphoma) consists of rituximab plus CHOP.
• Search result [8] mentions that treatment approaches such as rituximab/chemotherapy have been found to be effective in a large study of patients with stage I follicular lymphoma.

It's worth noting that the context provided is from 2024, and some search results may refer to older studies or treatments. However, based on the available information, it appears that there are various treatment options available for localized lymphoma, including first-line therapies like CHOP or bendamustine plus rituximab, as well as alternative treatments such as ADCs.

References:

• [3] K Laribi · 2018 · Cited by 42
• [4] (no specific reference)
• [5] (no specific reference)
• [6] (no specific reference)
• [7] Editor's Note: May 28 is World Blood Cancer Day ROCHESTER, Minn. — Chemotherapy is usually the first treatment doctors try to treat lymphoma, including the two most common forms: non-Hodgkin and Hodgkin.
• [9] Large B-cell lymphomas, representing 25% to 35% of adult non-Hodgkin lymphomas, are a collection of clinicopathologic entities, of which diffuse large B-cell lymphoma not otherwise specified (DLBCL) is the most common.

Differential Diagnosis of Obsolete Localized Lymphoma

Localized lymphomas are a type of non-Hodgkin lymphoma that presents with limited disease spread, often affecting specific areas such as the skin or lymph nodes. When considering differential diagnoses for obsolete localized lymphoma, several conditions must be ruled out.

• Benign reactive lymphoid hyperplasia: This condition is characterized by an overactive immune response, leading to the proliferation of lymphocytes in the affected area. It can mimic the presentation of lymphoma but is typically self-limiting and resolves without treatment [9].
• Urethral caruncle or diverticulum: These conditions involve abnormalities of the urethra and can present with similar symptoms to localized lymphoma, such as pain and swelling in the affected area [4].
• Malignant lymphoma: This is a type of cancer that affects the immune system, and its differential diagnosis from other conditions requires careful consideration. Lymphoma can present with a range of symptoms, including pain, swelling, and fatigue.
• Sarcoma or extravesical leiomyoma of the bladder: These are rare types of cancer that can affect the urinary tract and may be considered in the differential diagnosis for localized lymphoma [4].
• Hydroa vacciniforme-like lymphoproliferative disorder: This is a rare condition characterized by an abnormal proliferation of lymphocytes, which can present with skin lesions and other symptoms similar to localized lymphoma [12].

Key Points

• Differential diagnoses for obsolete localized lymphoma include benign reactive lymphoid hyperplasia, urethral caruncle or diverticulum, malignant lymphoma, sarcoma or extravesical leiomyoma of the bladder, and hydroa vacciniforme-like lymphoproliferative disorder.
• Careful consideration is required to rule out these conditions when diagnosing localized lymphoma.

References

[4] by AKG Venyo · 2014 · Cited by 47 — Other differential diagnoses include urethral caruncle, urethral diverticulum [45, 46], malignant lymphoma, sarcoma, extravesical leiomyoma of the bladder, ... [9] Sep 1, 2012 — Diagnosis. Differential diagnosis. The following conditions must be ruled out: benign reactive lymphoid hyperplasia, benign ocular surface ... [12] A long-standing problem had been the differential diagnosis of lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL), since both are usually associated with plasmacytic differentiation in the neoplastic cells. ... localized forms such as hydroa vacciniforme-like lymphoproliferative disorder and severe mosquito bite allergy to a ...