clear cell cystadenofibroma

Clear Cell Cystadenofibroma: A Rare Benign Ovarian Tumor

Clear cell cystadenofibroma is a type of benign ovarian tumor that contains both epithelial and fibrous stromal components. It is characterized by the presence of clear or hobnail cells within a dense fibrous stroma and cystic structures [7][14].

Key Features:

• A benign neoplasm of glandular epithelium
• Presence of clear or hobnail cells within a dense fibrous stroma and cystic structures
• Can vary in appearance from solid areas with knobby papillae to firm confluent areas
• May resemble a malignant tumor on imaging due to its complex appearance [13]

Imaging Characteristics:

• On T2W imaging, the solid component of the tumor is of very low signal intensity and contains very high signal intensity cysts producing a “black sponge”–like appearance [4]
• Can appear as a multilocular cystic mass with low signal intensity peripherally distributed contents

Clinical Presentation:

• Usually presents as a round and hard tumor with papillary growing nodules at the surface
• May have a distinct border and contain a blue-gray cyst approximately 7cm in size [6]

Prognosis:

• Excellent prognosis due to its benign nature
• Rarely associated with malignant transformation

Note: The information provided is based on the search results and may not be an exhaustive list of features or characteristics.

Diagnostic Tests for Clear Cell Cystadenofibroma

Clear cell cystadenofibroma, a rare benign ovarian tumor, can be challenging to diagnose using imaging tests alone. However, various diagnostic tests can help confirm the diagnosis and rule out other conditions.

• Imaging Tests: Ultrasound and computed tomography (CT) scans are commonly used to evaluate the size, shape, and structure of the ovaries. These tests may show a complex solid and cystic mass, but it's often difficult to differentiate clear cell cystadenofibroma from malignant pathology [2].
• Blood Tests: Blood tests can help determine the presence of tumor markers or other biochemical indicators that may be associated with ovarian tumors.
• Frozen-Section Diagnosis: In some cases, a frozen-section diagnosis may be helpful in confirming the diagnosis of clear cell cystadenofibroma during surgery. This can save time and avoid aggressive surgical management [10].

Key Points to Consider

• Imaging tests alone may not be sufficient to confirm the diagnosis of clear cell cystadenofibroma.
• Blood tests and frozen-section diagnosis can provide additional information to support the diagnosis.
• A multidisciplinary approach, involving gynecologists, radiologists, and pathologists, is essential for accurate diagnosis and management.

References

[1] Ovarian cystadenofibroma (CAF) is a rare benign tumour that accounts for 1.7% of all ovarian neoplasms [11]. [2] by G Avesani · 2021 · Cited by 13 — Ovarian cystadenofibroma is a benign ovarian tumor that is characterized by a consistent percentage of masses, which remain indeterminate in ultrasonography [2]. [10] This finding may help a radiologist make a preoperative diagnosis of this tumor and thus perhaps avoid aggressive surgical management. Keywords: Magnetic resonance imaging, ovarian cystadenofibroma, sonography [12].

Differential Diagnosis of Clear Cell Cystadenofibroma

Clear cell cystadenofibroma is a rare type of ovarian tumor, and its differential diagnosis can be challenging. Based on the available information, here are some conditions that should be considered in the differential diagnosis:

• Clear cell adenofibroma: This is an extremely rare condition that can mimic clear cell cystadenofibroma. However, it is characterized by the absence of cytologic atypia [5].
• Benign serous cystadenoma with focal epithelial proliferation: This condition can also be considered in the differential diagnosis, particularly if there are findings of a benign serous cystadenoma with focal epithelial proliferation [6].
• Rete cyst/cystadenoma: This is another condition that should be ruled out in the differential diagnosis, especially if there are findings of a rete cyst or cystadenoma.
• Ovarian masses with fibrous components: Conditions such as fibroma, fibrothecoma, and Brenner's tumor can also be considered in the differential diagnosis, particularly if there are findings of ovarian masses with fibrous components [8].
• High-grade serous carcinoma (HGSC): This is a type of ovarian cancer that should be ruled out in the differential diagnosis, especially if there are findings of clear cytoplasm.
• Endometrioid neoplasia of the ovary (ENOC): This is another type of ovarian cancer that can be considered in the differential diagnosis, particularly if there are findings of clear cytoplasm.
• Yolk sac tumor: This is a rare type of ovarian germ cell tumor that should be ruled out in the differential diagnosis.
• Dysgerminoma: This is a type of