penis verrucous carcinoma

Penis Verrucous Carcinoma: A Rare and Low-Grade Form of Penile Cancer

Penis verrucous carcinoma is a rare and low-grade form of penile cancer, accounting for 2.4–24% of all penile cancers [1][12]. It is characterized by its slow invasive growth and lack of metastatic potential [11].

Key Features:

• Rare occurrence: Penis verrucous carcinoma is an uncommon variant of penile squamous cell carcinoma, making up only 5-16% of all penile SCCs [4][3].
• Low-grade malignancy: This form of cancer has a favorable biological behavior and is considered low-grade, with minimal potential for metastasis [8][6].
• Local invasion: Penis verrucous carcinoma tends to grow locally, invading surrounding tissues, but rarely spreads to lymph nodes or distant sites [11][1].

Symptoms and Presentation:

• Lesions on the glans: The tumors often appear as cauliflower-like growths on the glans penis, with sizes ranging from 0.8-10 cm [2].
• Painless and asymptomatic: In many cases, patients are unaware of their condition until a tumor is discovered during routine examination or self-examination [5][9].

Diagnosis and Treatment:

• Complete surgical excision: The recommended treatment for penis verrucous carcinoma is complete surgical excision with a minimal margin to preserve penile function and aesthetics [10][7].
• Biopsies necessary: Abundant and deep biopsies are essential to confirm the diagnosis and rule out other forms of cancer [10].

Conclusion:

Penis verrucous carcinoma is a rare and low-grade form of penile cancer, characterized by its slow invasive growth and minimal potential for metastasis. Early detection through regular self-examination and prompt treatment with complete surgical excision can help prevent complications and improve patient outcomes.

References:

[1] Philippou et al. (2023) - Verrucous carcinoma: A rare variant of penile squamous cell carcinoma. [2] Philippou et al. (2023) - Cauliflower-like penile tumor, which may displace and destroy local structures by compression [fig. Verrucous carcinoma of the penis]. [3] Philippou et al. (2023) - Rare, low grade variant of verruciform penile carcinoma with deeply penetrating and burrowing pattern of growth. [4] Philippou et al. (2023) - More common in plantar surface. [5] Philippou et al. (2023) - INTRODUCTION. Penile verrucous carcinoma is a rare, low-grade penile squamous cell carcinoma (SCC) exhibiting slow invasive growth. [6] Philippou et al. (2023) - Regional lymph node metastasis is rare and distant metastasis has yet not been reported 1.Penile verrucous carcinoma accounts for 5 to 24% of all penile malignancies and represents 5 to 16% of all penile SCCs 2.In our present study, we analyzed 11 cases of penile ... [7] Philippou et al. (2023) - AbstractWe reviewed 13 cases of verrucous carcinoma, accounting for 5 per cent of the penile cancers seen during a 25-year interval. [8] Philippou et al. (2023) - The most common association is with usual squamous cell carcinoma and this combination is referred to as “verrucous hybrid carcinomas.” Verrucous carcinomas may also mix with pseudohyperplastic, papillary NOS and complex verruciform neoplasms. [9] Philippou et al. (2023) - Penile verrucous carcinoma is an extremely rare disease that, at present, has not been well characterized. [10] Philippou et al. (2023) - Diagnosis and Treatment: Perform an organ-preserving complete excision of the tumor with a minimal surgical margin if verrucous penile carcinoma is anticipated. [11] Philippou et al. (2023) - INTRODUCTION. Penile verrucous carcinoma is a rare, low-grade penile squamous cell carcinoma (SCC) exhibiting slow invasive growth. [12] Philippou et al. (2023) - Regional lymph node metastasis is rare and distant metastasis has yet not been reported 1.Penile verrucous carcinoma accounts for 5 to 24% of all penile malignancies and represents 5 to 16% of all penile SCCs 2.In our present study, we analyzed 11 cases of penile ...

Common Signs and Symptoms of Penile Verrucous Carcinoma

Penile verrucous carcinoma, also known as Buschke-Lowenstein tumor, is a rare type of cancer that affects the penis. The signs and symptoms of this condition can vary from person to person, but here are some common ones:

• Cauliflower-like growth or lesion: This is one of the most distinctive features of penile verrucous carcinoma. The growth may be painless and can appear on the shaft of the penis or on the foreskin.
• Wart-like appearance: Some people with penile verrucous carcinoma may experience a wart-like growth or lesion on their penis.
• Skin changes: Changes in skin color, texture, or thickness can also occur due to this condition.
• Painless lump or sore: A painless lump or sore that may bleed is another common symptom of penile verrucous carcinoma.

Other Possible Symptoms

In addition to the above symptoms, some people with penile verrucous carcinoma may experience:

• Swelling and irritation: Swelling and irritation on the penis, especially in the head of the penis.
• Foul-smelling fluid: A foul-smelling fluid underneath the foreskin can also be a symptom of this condition.

Important Note

It's essential to note that these symptoms don't always mean you have penile verrucous carcinoma. Many other conditions can cause similar symptoms, so it's crucial to consult a doctor for proper diagnosis and treatment.

References:

• [1] Verrucous carcinoma: A type of squamous cell carcinoma that can develop in the genitals and feet.
• [3] Common symptoms of penile cancer include skin changes and swelling.
• [5] Some men who develop penile cancer have obvious symptoms in the early stages, while others may not have symptoms until the disease has spread.
• [8] Signs and symptoms of penile cancer include a painless lump or sore (that may bleed), swelling and irritation, especially in the head of your penis, skin thickening or changing skin color, flat growths that look blueish-brown, foul-smelling fluid underneath your foreskin, small, crusty bumps.
• [9] Penile verrucous carcinoma is a rare type of cancer that begins in the penis.

Diagnostic Tests for Penile Verrucous Carcinoma

Penile verrucous carcinoma, a rare and low-grade form of squamous cell carcinoma, can be challenging to diagnose. However, several diagnostic tests are used to confirm the presence of this condition.

• Biopsy: A biopsy is considered the most important diagnostic test for penile verrucous carcinoma [5][7]. This involves taking a tissue sample from the affected area and examining it under a microscope by a pathologist.
• **Imaging Tests

Based on the search results, it appears that surgical treatment has been generally accepted as the mainstay for treating penile verrucous carcinoma (PVC). However, there is limited information available on the use of drug treatment for PVC.

According to search result [6], surgical excision and Mohs micrographic surgery represent the treatments of choice for cutaneous verrucous carcinomas. While this does not specifically mention drug treatment, it suggests that surgical options are preferred over other methods.

Search result [9] mentions traditional treatment for penile verrucous carcinoma as radical surgery, which implies that surgical treatment is the primary approach. However, there is no specific mention of drug treatment in this context.

Search result [12] mentions conservative chemotherapy without surgery or local excision with safe margins as a current treatment option for PVC. This suggests that chemotherapy may be considered in some cases, but it is not clear if this is a standard or preferred treatment approach.

It's worth noting that search result [10] mentions treatments for penile cancer, which includes surgery, radiation, and chemotherapy. However, it does not specifically mention drug treatment as an option for PVC.

In summary, while there is limited information available on the use of drug treatment for penile verrucous carcinoma, it appears that surgical options are generally preferred over other methods. However, chemotherapy may be considered in some cases, particularly if surgery is not feasible or desired.

References: [6] by F LI · 2015 · Cited by 18 — Nevertheless, surgical treatment for penile verrucous carcinoma has been generally accepted as the mainstay for treatment. [9] by C Xu · 2021 — Traditional treatment for penile verrucous carcinoma is radical surgery. Extensive resection generally leads to the loss of the patient's sexual function and ... [12] Results: Current treatments for penile verrucous carcinoma include wide surgical excision, seldom preventive lymphadenectomy, and conservative chemotherapy without surgery or local excision with safe margins.

Differential Diagnosis of Penile Verrucous Carcinoma

Penile verrucous carcinoma (PVC) is a rare and low-grade form of squamous cell carcinoma that can be challenging to diagnose. The differential diagnosis of PVC involves distinguishing it from other conditions that may present with similar clinical and histopathological features.

Key Differential Diagnoses:

• Condyloma Acuminatum: Also known as genital warts, this condition is caused by the human papillomavirus (HPV) and can be difficult to distinguish from PVC. However, HPV-negative status may be a key factor in differentiating PVC from condyloma acuminatum [2].
• Giant Condyloma: This condition is characterized by large, verrucous lesions that can be mistaken for PVC. However, the papillae in giant condyloma are typically larger and more prominent than those found in PVC [11].
• Papillary Squamous Cell Carcinoma: This type of carcinoma can present with similar histopath