obsolete recurrent extrahepatic bile duct cancer

Common Signs and Symptoms

Recurrent extrahepatic bile duct cancer can cause a range of symptoms, which may vary in severity and frequency. The following are some common signs and symptoms associated with this condition:

• Jaundice: A yellowing of the skin and whites of the eyes due to bile buildup in the body [1][2][4][5]
• Weight loss: Unintentional weight loss, which can be significant in advanced cases [1][4][7]
• Abdominal pain: Pain or discomfort in the upper abdomen, which may worsen over time [2][7]
• Itchy skin (pruritus): Itching sensation on the skin, often accompanied by jaundice [2][9]
• Nausea and vomiting: Feeling queasy or experiencing vomiting, especially after eating [3][9]
• Pale stools: Stools that are pale in color due to bile duct obstruction [1][4]
• Dark urine: Urine that is darker than usual due to the buildup of bilirubin [8]

Other Possible Symptoms

In addition to these common symptoms, some people with recurrent extrahepatic bile duct cancer may experience:

• Fever: Elevated body temperature, which can be a sign of infection or other complications [8]
• Weakness and shivering: Feeling weak or experiencing chills, especially in advanced cases [8]
• A lump in the stomach: A palpable mass in the upper abdomen, which may indicate tumor growth [9]

It's essential to note that not everyone with recurrent extrahepatic bile duct cancer will experience all of these symptoms. If you're concerned about your health or have been diagnosed with this condition, consult with a healthcare professional for personalized guidance and care.

References:

[1] Mar 28, 2024 — Clinical Features​​ Distal and perihilar bile duct cancers frequently cause biliary tract obstruction, leading to the following symptoms: ...

[2] by VB Salvador · 2013 · Cited by 3 — It has been reported that the major symptoms of cholangiocarcinoma were abdominal pain, weight loss, pruritus and jaundice but about one quarter ...

[3] Gallbladder and biliary tract cancer symptoms may include: Jaundice (yellowing of the skin and whites of the eyes) Unexplained nausea and vomiting.

[4] Clinical Features​​ Distal and perihilar bile duct cancers frequently cause biliary tract obstruction, leading to the following symptoms: Jaundice. Weight loss.

[5] People with bile duct cancer may experience the following symptoms or signs: Jaundice, which is a yellowing of the skin and the whites of the eyes.

[6] by D Buchner · 2016 · Cited by 1 — Chemotherapy was planned for 6 months but discontinued after 3 months due to head aches and weight loss. As of April 2016, there are no signs of ...

[7] Cholangiocarcinoma may be asymptomatic in the early stages. Classic symptoms of painless jaundice, weight loss, and abdominal pain usually appear in advanced ...

[8] May 1, 2024 — Symptoms · jaundice or yellowing of the eyes and skin · itchy skin · darker urine · pale stool · fever · weakness · shivering · a lump in the stomach ...

[9] He presented with a 1-month history of jaundice, pruritus, nausea, anorexia and pale stools. He reported no rashes, fevers, hospitalizations or other medical ...

Diagnostic Evaluation for Recurrent Extrahepatic Bile Duct Cancer

Recurrent extrahepatic bile duct cancer (EHBDC) is a challenging condition to diagnose, and the diagnostic tests used may vary depending on the individual case. However, based on the available information, here are some of the diagnostic tests that can be used for recurrent EHBDC:

• Imaging Tests:

Based on the provided context, it appears that there are several treatment options available for recurrent extrahepatic bile duct cancer.

• Systemic chemotherapy: This is a common treatment approach for unresectable, metastatic, or recurrent bile duct cancer. The following chemotherapy drugs may be used: [2]
  • Systemic chemotherapy sends the medicine through your entire body to kill cancer cells or shrink tumors.
• Targeted therapy: For advanced bile duct cancers that have specific gene mutations (gene changes), targeted therapy drugs might be an option. [3]
• Stent placement or biliary bypass: This may be used as a treatment for unresectable, recurrent, or metastatic distal extrahepatic bile duct cancer. [4][8][9]
• Leucovorin-modulated 5-fluorouracil, capecitabine monotherapy, or single agent gemcitabine: These are reasonable options for patients with a borderline performance status. [14]

Additionally, there is evidence that suggests the use of Durvalumab in combination with Gemcitabine and Cisplatin may be effective in treating locally advanced or metastatic Biliary Tract cancer, which includes extrahepatic bile duct cancer. [15]

It's worth noting that treatment options may vary depending on individual circumstances, and it's essential to consult with a healthcare professional for personalized advice.

References: [2] - Systemic chemotherapy is used to treat unresectable, metastatic, or recurrent bile duct cancer. [3] - Targeted therapy: For advanced bile duct cancers that have specific gene mutations (gene changes), targeted therapy drugs might be an option. [4] - Treatment of unresectable, recurrent, or metastatic distal extrahepatic bile duct cancer may include the following: Stent placement or biliary bypass as ... [8] - Treatment of unresectable, recurrent, or metastatic distal extrahepatic bile duct cancer may include the following: Stent placement or biliary bypass as ... [9] - Feb 26, 2019 — Treatment of unresectable, recurrent, or metastatic distalextrahepatic bile duct cancer may include the following: Stent placement or ... [14] - Leucovorin-modulated 5-fluorouracil, capecitabine monotherapy, or single agent gemcitabine are reasonable options for patients with a borderline performance status. [15] - SUMMARY: The FDA on September 2, 2022, approved IMFINZI® (Durvalumab) in combination with Gemcitabine and Cisplatin for adult patients with locally advanced or metastatic Biliary Tract cancer.

Based on the provided context, it appears that you are looking for differential diagnoses for a type of cancer that affects the extrahepatic bile ducts.

Possible Differential Diagnoses:

• Benign biliary strictures: These can be caused by various factors such as inflammation, trauma, or iatrogenic injury. According to [9], benign biliary strictures can present with similar symptoms to malignant tumors and should be considered in the differential diagnosis.
• Primary sclerosing cholangitis (PSC): This is a chronic liver disease characterized by inflammation and fibrosis of the bile ducts. PSC can cause recurrent obstruction of the bile ducts, which may mimic the symptoms of extrahepatic bile duct cancer [10].
• Biliary obstruction or stricture: These conditions can cause recurrent blockage of the bile ducts, leading to similar symptoms as extrahepatic bile duct cancer.
• Vanishing bile duct syndrome (VBDS): This is an acquired disease characterized by loss of small and medium-sized intrahepatic bile ducts. While VBDS primarily affects the intrahepatic bile ducts, it may also involve the extrahepatic bile ducts in some cases [8].

Other Considerations:

• Cholangiocarcinoma: This is a type of cancer that affects the bile ducts and should be considered in the differential diagnosis of recurrent extrahepatic bile duct cancer.
• Gallbladder and biliary tract cancer: These are rare cancers that can affect the gallbladder and bile ducts, respectively. They may present with similar symptoms to extrahepatic bile duct cancer [6].

References:

[8] - The vanishing bile duct syndrome (VBDS) is an acquired disease resulting in loss of small and medium-sized intrahepatic bile ducts. [9] - We describe the salient clinical and imaging manifestations of benign biliary strictures that will help radiologists to accurately diagnose these entities. [10] - Differential diagnoses of PBC may include such hepatic and systemic conditions as biliary obstruction or stricture, primary sclerosing cholangitis, hepatitis, ...