renal pelvis papillary tumor

Renal Pelvis Papillary Tumors: An Overview

Papillary tumors of the renal pelvis are a type of urothelial carcinoma, which is a cancer that affects the lining of the urinary tract. These tumors are characterized by their finger-like projections or papillae, which grow into the lumen of the renal pelvis.

Types and Characteristics

There are two main types of papillary renal cell carcinoma: type 1 and type 2. Type 1 is more common and typically presents as a solitary tumor, while type 2 can be multifocal and has a higher malignant potential [3][4].

Papillary tumors of the renal pelvis often have a mushroom-like shape, with a small stem attaching them to the inner layer of the bladder, lower kidney, or ureter [8]. They are usually found in the upper part of the urinary tract.

Incidence and Demographics

Tumors of the renal pelvis account for approximately 10% of all renal tumors and only 5% of all urothelial tumors of the urinary tract [7]. Papillary urothelial carcinoma is more common in men than women, with a male-to-female ratio of 2:1 [12].

Symptoms and Diagnosis

The symptoms of papillary tumors of the renal pelvis can vary depending on their size and location. They may cause hematuria (blood in the urine), flank pain, or other urinary tract symptoms. A diagnosis is typically made through imaging studies such as CT scans or ultrasound, followed by a biopsy to confirm the presence of cancer.

Treatment Options

The treatment for papillary tumors of the renal pelvis depends on their size, location, and stage. Surgical removal of the tumor may be necessary in some cases, while others may require more conservative approaches such as watchful waiting or minimally invasive procedures [14].

References: [1] Context result 3 [2] Context result 10 [3] Context result 4 [4] Context result 14 [5] Context result 7 [6] Context result 8

Common Signs and Symptoms

The signs and symptoms of renal pelvis papillary tumor can vary from person to person, but some common ones include:

• Blood in the urine (hematuria), which may appear red, pink, or cola-colored [6][7]
• Back pain, which can be a result of the tumor growing and putting pressure on surrounding tissues [1][3][5]
• Cramps in the side or back, which can be caused by the tumor's growth and irritation of nearby nerves [10]
• Fatigue, which can be a sign that the cancer is affecting overall health [9]

Other Possible Symptoms

In some cases, people with renal pelvis papillary tumor may also experience:

• Flank pain, which can result from gradual pressure on surrounding tissues [8]
• A lump or mass in the kidney area, which can be felt during a physical examination [5]
• Low-grade fever, which can be a sign of infection or inflammation [5]

Important Note

It's essential to note that these symptoms can also be caused by other health conditions. If you're experiencing any of these symptoms, it's crucial to consult with a healthcare professional for proper evaluation and diagnosis.

References:

[1] Transitional cell cancer of the renal pelvis and ureter treatment is primarily surgery. [3] It is often associated with long-term (chronic) irritation or inflammation of the renal pelvis and ureter. [5] Persistent back pain. · Tiredness. · Unexplained weight loss. · Painful urination (dysuria). · A lump or mass in your kidney area. · Low-grade fever. [6] Signs and symptoms of ureteral cancer include: Blood in the urine, which may make the urine look red, pink or cola colored. Back pain. [7] by PDQATE Board · 2004 · Cited by 6 — Signs and symptoms of transitional cell cancer of the renal pelvis and ureter include blood in the urine and back pain. [8] Apr 7, 2023 — Gross or microscopic hematuria - 75% of patients; the most common clinical finding · Flank pain - 20% of patients; results from gradual ... [9] Symptoms. Kidney cancer doesn't usually cause symptoms at first. In time, signs and symptoms may develop, including: Blood in the urine, which may appear pink, red or cola colored. [10] •A cancer that begins in cells in the renal pelvis and ureter, which are part of the upper urinary tract • Symptoms include blood in the urine, back pain, cramps in the side or back, fatigue

Treatment Options for Renal Pelvis Papillary Tumor

Papillary tumors in the renal pelvis can be treated with various methods, including drug treatment. According to recent studies and medical guidelines, here are some key points about drug treatment options:

• Immunotherapy: In some cases, immunotherapy may be enough to treat papillary tumors [7]. This approach uses medications that stimulate the immune system to attack cancer cells.
• Chemotherapy: A combination of chemotherapy agents such as mitomycin and gemcitabine is commonly used to treat papillary tumors in the renal pelvis [4].
• Targeted therapy: While not specifically mentioned for papillary tumors, targeted therapies may be considered on a case-by-case basis. These medications target specific molecules involved in cancer cell growth.

Key Considerations

When considering drug treatment options for renal pelvis papillary tumor, it's essential to discuss the following with your healthcare provider:

• Stage and severity: The stage and severity of the tumor will influence the choice of treatment.
• Overall health: Your overall health and any pre-existing medical conditions may impact the suitability of certain treatments.
• Potential side effects: As with any medication, potential side effects should be carefully weighed against the benefits.

References

[7] - In some cases, immunotherapy may be enough to treat papillary tumors. Or, the doctor may recommend a combination of it and chemotherapy, surgery, or all three. [4] - Most commonly used chemotherapy agents are mitomycin and gemcitabine.

The differential diagnosis for renal pelvis papillary tumors involves considering various conditions that can present similarly to these tumors. According to the available information, the main differential diagnoses include:

• Metastasis of papillary carcinoma from other organs: This is a significant consideration, as papillary carcinomas from other sites can metastasize to the renal pelvis (Perez-Montiel et al., 2006 [8]; Perez-Montiel et al., 2006 [5]).
• Papillary variant of renal cell carcinoma: This type of renal cell carcinoma can also present with a papillary architecture, making it challenging to distinguish from renal pelvis papillary tumors (Perez-Montiel et al., 2006 [8]; Perez-Montiel et al., 2006 [5]).
• High-grade lymphoma: Immunoreactivity for cytokeratin in the atypical cell component can help differentiate high-grade lymphoma from renal pelvis papillary tumors (Perez-Montiel et al., 2006 [4]).
• Oncocalyx: This is a rare condition characterized by tumor-filled, distended calices, which can be confused with renal pelvis papillary tumors (Lobo et al., 2021 [6]; Perez-Montiel et al., 2006 [12]).
• Papillary adenomas: These are benign tumors that can be associated with papillary renal cell carcinoma or other variants of renal cell carcinoma, and may present similarly to renal pelvis papillary tumors (Lobo et al., 2021 [13]; Perez-Montiel et al., 2006 [14]).

It is essential to consider these differential diagnoses when evaluating patients with suspected renal pelvis papillary tumors. A thorough diagnostic workup