obsolete human papilloma virus related vulvar squamous cell carcinoma

Common Signs and Symptoms of Vulvar Squamous Cell Carcinoma

Vulvar squamous cell carcinoma, a type of cancer that affects the vulva, can exhibit various signs and symptoms. While these may not be unique to this condition, they are commonly associated with it.

• Lumps or bumps: A lump, wartlike bump, or an open sore on the vulva is one of the most common symptoms of vulvar squamous cell carcinoma [1].
• Changes in skin color: Changes in vulvar skin color, such as redness or discoloration, can be a sign of this condition [2].
• Itching and irritation: Persistent itching, pain, or burning sensations in the vulvar area are also common symptoms [3][7].
• Lymph node swelling: Swollen lymph nodes in the groin area can indicate that the cancer has spread [6].

Other Possible Symptoms

In some cases, vulvar squamous cell carcinoma may not exhibit any noticeable symptoms. However, if left untreated, it can lead to more severe complications.

• Bleeding or discharge: Blood, pus, or other discharge coming from a lesion or sore spot in the vulva can be a sign of this condition [4].
• Tenderness and pain: Tenderness or soreness in the vulvar area can also be associated with vulvar squamous cell carcinoma [5].

Important Note

It's essential to note that these symptoms can be similar to those experienced by women with other conditions, such as lichen sclerosus or genital warts. A proper diagnosis from a healthcare professional is necessary to determine the underlying cause of these symptoms.

References:

[1] Symptoms. Signs and symptoms of vulvar cancer may include: A lump, wartlike bump or an open sore on the vulva. [2] Vulvar cancer is a rare cancer of your vulva. Symptoms include changes in vulvar skin color... [3] Persistent itching, pain or burning in the vulvar area [4] blood, pus or other discharge coming from a lesion or sore spot in the vulva. [5] Tenderness or soreness [6] Swollen lymph nodes in the groin area can indicate that the cancer has spread [7] Bleeding

Based on the provided context, it appears that there are several diagnostic tests and methods used to identify human papillomavirus (HPV) related vulvar squamous cell carcinoma.

Screening Methods:

• Regular pelvic examinations [7]
• Pelvic ultrasound [7]
• Blood tests for the ovarian cancer-associated antigen, CA 125 [7]

These screening methods can help identify potential cases of vulvar squamous cell carcinoma, but they may not be specific to HPV-related cases.

Diagnostic Tests:

• Pap smear and specific HPV test: This combined test is recommended for managing women with atypical squamous cells of undetermined significance (ASC-US) [2]. However, it's essential to note that a negative result using this test means future screening is necessary every 3 years thereafter.
• HPV DNA testing: This test is recommended for managing women with ASC-US and can help identify HPV-related cases [2].
• Colposcopy: This procedure involves examining the vulva and vagina with a special microscope to look for abnormal cell changes. It's often used in conjunction with other diagnostic tests [9].

Molecular Tests:

• p16 and p53 testing: These molecular tests can help distinguish between HPV-associated and HPV-independent vulvar squamous cell carcinomas [14]. However, it's essential to note that this distinction is imperfect on morphological assessment alone.

It's worth noting that there is currently no proven screening test to prevent vulval cancer [9]. Women with multi-focal HPV-related disease should be followed up with colposcopy of the vulva and vagina [9].

References:

[2] - Aug 22, 2024 [7] - Aug 22, 2024 [9] - by J Morrison · 2024 · Cited by 6 [14] - Vulvar squamous neoplasms – intraepithelial and invasive – are now classified by their aetiological relationship with human papillomavirus.

Treatment Options for Obsolete HPV-related Vulvar Squamous Cell Carcinoma

Vulvar squamous cell carcinoma (VSCC) is a type of cancer that affects the vulva, and in some cases, it can be caused by human papillomavirus (HPV). While there are no specific treatments mentioned in the search results for obsolete HPV-related VSCC, we can discuss some general treatment options for this condition.

• Platinum-based therapies: According to search result [14], platinum-based therapies demonstrate the greatest activity available for treating surgically unresectable squamous cell cancer of the vulva, advanced disease with distant metastases, or recurrent disease previously treated with surgery and/or radiation with or without chemotherapy.
• Bevacizumab: Search result [5] mentions Bevacizumab, a monoclonal antibody directed against VEGF, which has been used as an adjunct in the treatment of many gynaecological malignancies. However, its effectiveness for obsolete HPV-related VSCC is not specified.
• Bintrafusp alfa: Search result [4] mentions Bintrafusp alfa, a drug that binds to two target proteins, PD-L1 and TGF-beta, which shrank tumors of some patients with advanced HPV-related cancers. However, its effectiveness for obsolete HPV-related VSCC is not specified.

Note on Obsolete Disease

It's worth noting that the term "obsolete" is not typically used in medical contexts to describe a disease or condition. It's possible that this term was used to indicate that the disease has become less common or less relevant due to advances in treatment or prevention strategies.

References:

• [14] - This search result mentions platinum-based therapies as an option for treating surgically unresectable squamous cell cancer of the vulva, advanced disease with distant metastases, or recurrent disease previously treated with surgery and/or radiation with or without chemotherapy.
• [5] - This search result mentions Bevacizumab as a treatment option for gynaecological malignancies, but does not specify its effectiveness for obsolete HPV-related VSCC.
• [4] - This search result mentions Bintrafusp alfa as a treatment that shrank tumors of some patients with advanced HPV-related cancers, but does not specify its effectiveness for obsolete HPV-related VSCC.

Based on the provided context, it appears that there are several conditions that can be considered in the differential diagnosis of human papillomavirus (HPV)-related vulvar squamous cell carcinoma. Here are some possible options:

• Molluscum contagiosum: This is a viral infection caused by the molluscum contagiosum virus, which can cause small, flesh-colored bumps on the skin. According to [9], molluscum contagiosum should be considered in the differential diagnosis of vulvar lesions.
• Condyloma latum (CL): CL is a type of genital wart caused by HPV, and it can appear as a flat or raised lesion on the vulva. As mentioned in [9], CL should also be considered in the differential diagnosis of vulvar lesions.
• Vulvar papillomatosis: This is a rare condition characterized by the growth of multiple small, benign tumors (papillomas) on the vulva. While it's not directly related to HPV, it can be considered in the differential diagnosis of vulvar lesions with similar characteristics [9].
• Pearly penile papules: These are small, harmless bumps that appear on the penis and are caused by a viral infection. However, they can also be considered in the differential diagnosis of vulvar lesions, especially if they have similar characteristics [9].

It's essential to note that these conditions should not be confused with vulvar squamous cell carcinoma, which is a type of cancer. A proper diagnosis requires a thorough examination and consultation with a healthcare professional.

References:

[9] by D Diţescu · 2021 · Cited by 22 — Differential diagnosis of CA includes the following entities: molluscum contagiosum, condyloma latum (CL), vulvar papillomatosis, pearly penile papules, ...