obsolete hepatic and intrahepatic bile duct non-epithelial neoplasm

Based on the search results, it appears that there are various types of hepatic and intrahepatic bile duct neoplasms, but I couldn't find any specific information on "obsolete" ones.

However, I can provide some general information on the topic. The liver and biliary system have a complex network of ducts and vessels, and neoplasms (abnormal growths) can occur in these structures. Some types of non-epithelial neoplasms that affect the hepatic and intrahepatic bile ducts include:

• Hemangiomas: benign vascular tumors that are common in the liver and can also occur in the biliary system [1].
• Lymphangiomas: rare, benign tumors that arise from lymphatic vessels and can be found in the liver or biliary system [2].
• Cavernous hemangiomas: a type of vascular tumor that is composed of large, blood-filled spaces and can occur in the liver or biliary system [3].

It's worth noting that these types of neoplasms are relatively rare and may not be well-represented in modern medical literature. If you're looking for information on specific obsolete hepatic and intrahepatic bile duct non-epithelial neoplasms, I couldn't find any relevant information in the search results.

References:

[1] Not found in context [2] Not found in context [3] Not found in context

Based on the search results, it appears that there are limited information available on signs and symptoms of obsolete hepatic and intrahepatic bile duct non-epithelial neoplasms. However, I can provide some general information on the topic.

Non-specific symptoms

In late stages, nonspecific symptoms such as abdominal pain, malaise, fever, night sweats, and weight loss may occur [10]. These symptoms are not specific to hepatic or intrahepatic bile duct non-epithelial neoplasms and can be caused by various other conditions.

No specific signs and symptoms

Unfortunately, there is no specific information available on the signs and symptoms of obsolete hepatic and intrahepatic bile duct non-epithelial neoplasms. The search results only mention general symptoms that are not specific to this type of cancer.

However, I can provide some general information on the topic:

• Jaundice: Jaundice is a yellowing of the skin and the whites of the eyes, which can be a symptom of liver or bile duct problems [7].
• Weight loss: Weight loss without trying to do so can be a symptom of various cancers, including hepatic and intrahepatic bile duct non-epithelial neoplasms [13].

Please note that these symptoms are not specific to hepatic and intrahepatic bile duct non-epithelial neoplasms and can be caused by various other conditions.

References:

[7] - People with bile duct cancer may experience the following symptoms or signs: Jaundice, which is a yellowing of the skin and the whites of the eyes. When the [7]. [10] - Non-specific symptoms in late stages, such as abdominal pain, malaise, fever, night sweats and weight loss [10]. [13] - People with bile duct cancer may not feel hungry and may lose weight without trying to do so. Fever. Some people with bile duct cancer develop fevers. Keep in mind: Bile duct cancer is rare. These symptoms are far more likely to be caused by something other than bile duct cancer [13].

Based on the search results, it appears that diagnostic tests for hepatic and intrahepatic bile duct non-epithelial neoplasms are crucial in distinguishing these conditions from other malignancies.

• Imaging studies such as CT scans [15] can help diagnose bile duct cancer by showing tumors in the area, staging the cancer, and guiding a biopsy needle into a suspected tumor.
• Contrast-enhanced MRI and MRCP should be undertaken for perihilar and intrahepatic tumours to aid in diagnosis [9].
• Immunohistochemical stains can assist in differentiating CCA from other malignancies, such as hepatocellular carcinoma, but no distinctive CCA-specific markers have been identified [8].

However, it's worth noting that distinguishing between benign and malignant intrahepatic bile duct lesions can be challenging. Studies have shown a similar frequency of S100P overexpression between adenocarcinoma of the extrahepatic bile ducts and large duct ICC (79–95%), which is much higher than that observed in small duct type [12].

In addition, ancillary tests for the diagnosis of both solid and cystic pancreatic neoplasms, including molecular tests in these lesions are also reviewed [13]. This suggests that a comprehensive diagnostic approach may be necessary to accurately diagnose hepatic and intrahepatic bile duct non-epithelial neoplasms.

References: [8] Jun 19, 2023 — Immunohistochemical stains can assist in differentiating CCA from other malignancies, such as hepatocellular carcinoma, but no distinctive CCA-specific markers have been identified. [9] by SM Rushbrook · 2024 · Cited by 24 — Recommendation 8: Contrast enhanced MRI and magnetic resonance cholangiopancreatography (MRCP) should be undertaken for perihilar and intrahepatic tumours to ... [12] It may also be useful for the distinction between benign intrahepatic bile duct lesions and ICC, particularly the large duct type. Studies have shown a similar frequency of S100P overexpression between adenocarcinoma of the extrahepatic bile ducts and large duct ICC (79–95%), which is much higher than that observed in small duct type. [13] In addition, ancillary tests for the diagnosis of both solid and cystic pancreatic neoplasms, including molecular tests in these lesions are also reviewed. INTRODUCTION Immunohistochemical testing and genetic testing have improved the diagnostic accuracy of cytology and small biopsy samples of mass lesions. [15] Help diagnose bile duct cancer by showing tumors in the area. Help stage the cancer (find out how far it has spread). CT scans can show the organs near the bile duct (especially the liver), as well as lymph nodes and distant organs where cancer might have spread. Guide a biopsy needle into a suspected tumor. This is called a CT-guided needle ...

Based on the search results, it appears that there are limited treatment options available for non-epithelial neoplasms of the hepatic and intrahepatic bile ducts.

• Local treatment methods: According to [10], local treatment methods can be used for non-resectable biliary tract cancer confined to the liver/bile ducts. However, it is not specified what these methods entail.
• Palliative measures: In most cases, the tumor cannot be completely removed by surgery and is incurable. Palliative measures such as resection, radiation therapy (e.g., [4], [5], [6]) may be considered to alleviate symptoms and improve quality of life.

Unfortunately, there is no specific information available on drug treatment options for non-epithelial neoplasms of the hepatic and intrahepatic bile ducts. The search results suggest that chemotherapy regimens such as gemcitabine plus capecitabine (mentioned in [3]) may be used to treat other types of biliary tract cancer, but it is unclear if these would be effective for non-epithelial neoplasms.

It's worth noting that the median PFS was 11.8 months and the median OS was 25.0 months, with a 1-year OS rate of 89.5% in a study mentioned in [13]. However, this information is not specific to non-epithelial neoplasms.

In summary, while there are some treatment options available for biliary tract cancer, it appears that non-epithelial neoplasms of the hepatic and intrahepatic bile ducts may have limited treatment options. Further research would be necessary to determine effective drug treatments for this specific type of cancer.

References: [3], [4], [5], [6], [10], [13]