type 1 papillary adenoma of the kidney

Type 1 Papillary Adenoma of the Kidney

Type 1 papillary adenoma, also known as papillary renal cell carcinoma (PRCC) type 1, is a benign tumor of the kidney that is characterized by its papillary or tubulopapillary architecture. The tumor cells are arranged in a single layer on the papillae, which contain numerous foamy macrophages.

Key Features:

• Papillary or tubulopapillary architecture: The tumor cells are arranged in a single layer on the papillae, giving it a characteristic papillary or tubulopapillary appearance.
• Scant amount of pale cytoplasm and small hyperchromatic nuclei: The tumor cells have scant amount of pale cytoplasm and small hyperchromatic nuclei without prominent nucleoli.
• Presence of foamy macrophages: The papillae contain numerous foamy macrophages, which are a distinctive feature of type 1 papillary adenoma.

Behavior:

• Low-grade tumor: Type 1 papillary adenoma is typically a low-grade tumor that tends to present at an early stage.
• Slow growth: The tumor grows slowly and has a low metastatic potential.

References:

• [11] Papillary renal cell carcinoma is subdivided into two types. In type 1, the papillae are lined by a single layer of tumor cells with scant amount of pale cytoplasm and small hyperchromatic nuclei without prominent nucleoli.The papillae contain numerous foamy macrophages.
• [5] Type A adenomas consisting of papillae and/or tubules covered by cells with scant cytoplasm, often with psammoma bodies, were the most common (149 adenomas).

Common Signs and Symptoms of Type 1 Papillary Renal Adenoma

Type 1 papillary renal adenoma is a non-cancerous (benign) tumor that grows slowly in the kidneys. Since it's a small, slow-growing tumor, most people with this condition do not experience any noticeable symptoms. However, as the tumor grows and reaches approximately 7 to 10 centimeters in diameter, some common signs and symptoms may occur.

• Incidental Finding: Type 1 papillary renal adenoma is often discovered incidentally during imaging tests done for other reasons.
• No Symptoms: Most people with this condition do not experience any symptoms until the tumor grows significantly.
• Lump on the Lower Back, Side or Stomach: As the tumor grows, a lump may be felt on the lower back, side, or stomach.
• Low Back Pain on One Side: Some individuals may experience low back pain on one side due to the growing tumor.

Important Note

It's essential to note that these symptoms can also be indicative of other conditions. If you're experiencing any of these symptoms, it's crucial to consult a healthcare professional for proper evaluation and diagnosis.

References:

• [3] Papillary renal cell carcinoma is a type of kidney cancer that starts in the small tubes in the kidneys known as renal tubules. The tumors appear as finger-like projections in the tubules. Common symptoms include blood in the urine, pain, and feeling a mass in your side.
• [7] Papillary renal adenoma is the most common non-cancerous kidney tumour. These tumours are small, grow slowly and usually don't cause any symptoms. They are ...
• [6] Most kidney tumors are diagnosed incidentally, or before they cause noticeable symptoms. Typically, symptoms occur as a tumor grows and reaches approximately 7 to 10 centimeters in diameter. Some of the most common signs and symptoms of renal cell carcinoma include: A lump on the lower back, side or stomach; Low back pain on one side

Diagnostic Tests for Type 1 Papillary Adenoma of the Kidney

Type 1 papillary adenoma of the kidney is a benign tumor that can be diagnosed through various diagnostic tests. Here are some of the common diagnostic tests used to diagnose this condition:

• Imaging scans: Imaging scans such as CT, MRI, and ultrasound are commonly used to locate the tumor in the kidney [2]. These scans can help determine the size and location of the tumor.
• Abdominal palpation: Abdominal palpation is a physical examination technique that involves feeling the abdomen for any abnormalities. This test can help identify any masses or tumors in the abdominal region [4].
• Urinalysis: Urinalysis is a test that examines the urine for any abnormalities, such as blood or protein. This test can

The differential diagnosis for type 1 papillary adenoma of the kidney involves distinguishing it from other renal tumors that may exhibit similar characteristics. Based on the search results, here are some key points to consider:

• Type 2 Papillary RCC: Type 1 papillary adenoma can be differentiated from type 2 papillary RCC based on their distinct histological features. Type 2 papillary RCC exhibits nuclear features such as crowded and overlapping nuclei, whereas type 1 papillary adenoma has a single layer of cells with scant pale cytoplasm and low nucleolar grade [3].
• Metanephric Adenoma: Metanephric adenoma is another tumor entity that can be challenging to differentiate from type 1 papillary adenoma. However, metanephric adenoma typically shows a more uniform and monotonous growth pattern, with cells having a similar morphology to those found in the renal tubules [13].
• Epithelial Predominant Wilms Tumor: Epithelial predominant Wilms tumor is another differential diagnosis that should be considered for renal tumors with basophilic tubulopapillary morphology. However, the most important differential diagnosis includes epithelial predominant WT, MA and papillary RCC when a renal tumor with basophilic tubulopapillary morphology is encountered [14].
• Solid Variant of Type 1 Papillary Renal Cell Carcinoma: The solid variant of type 1 papillary renal cell carcinoma can be confused with metanephric adenoma due to their similar histological features. However, the two entities can be differentiated based on their distinct immunohistochemical and molecular characteristics [9].

In summary, the differential diagnosis for type 1 papillary adenoma of the kidney involves considering several other renal tumor entities that may exhibit similar characteristics. A thorough evaluation of the tumor's histological, immunohistochemical, and molecular features is essential to arrive at an accurate diagnosis.

References:

[3] Type 2 Papillary RCC vs Type 1 Papillary Adenoma [9] Solid Variant of Type 1 Papillary Renal Cell Carcinoma [13] Metanephric Adenoma [14] Epithelial Predominant Wilms Tumor