type 2 papillary adenoma of the kidney

Type 2 Papillary Adenoma of the Kidney

Type 2 papillary adenoma of the kidney is a rare and benign tumor that can be found in the kidneys. It is characterized by its papillary architecture and high-grade eosinophilic cytology.

• Definition: Type 2 papillary adenoma is a type of renal tumor that was previously classified as "type 2 PRCC" but is now known to represent a heterogeneous group of tumors, including PRCC, but also other previously unrecognized types of renal cell carcinomas with distinct molecular findings [5].
• Characteristics: These tumors have a papillary architecture and high-grade eosinophilic cytology. They are often confused with type 2 papillary renal cell carcinoma (PRCC), but they can be distinguished by their distinct molecular features [5].
• Incidence: The exact incidence of type 2 papillary adenoma is not well established, but it is considered to be a rare tumor.
• Clinical significance: Type 2 papillary adenoma is generally considered to be a benign tumor and does not typically require aggressive treatment. However, its distinction from malignant tumors such as PRCC is crucial for proper diagnosis and management.

References

[5] Some tumors with papillary architecture and high-grade eosinophilic cytology (previously classified as “type 2 PRCC”), are now known to represent a heterogeneous group of tumors which includes PRCC, but also includes other previously unrecognized, but distinctive types of renal cell carcinomas characterized by distinct molecular findings [5]. [12] Papillary Adenomas and Other Small Epithelial Tumors in the Kidney: An Autopsy Study. Caliò A, Warfel KA, Eble JN Am J Surg Pathol 2019 Feb;43(2):277-287. doi: 10.1097/PAS.0000000000001189. PMID: 30418186

Warning Signs of Type 2 Papillary Renal Cell Carcinoma

Type 2 papillary renal cell carcinoma is a subtype of kidney cancer that can be challenging to diagnose in its early stages. While it may not produce any noticeable symptoms, as the tumor grows, warning signs may begin to appear. Here are some common signs and symptoms associated with type 2 papillary renal cell carcinoma:

• Blood in the urine: Hematuria is a classic symptom of kidney cancer, including type 2 papillary renal cell carcinoma [3].
• Pain in the side: Flank pain or discomfort can be a sign of an underlying tumor [9].
• Unexplained weight loss: A significant and unexplained drop in body weight can be a red flag for various types of cancers, including kidney cancer [5].
• Excessive fatigue: Feeling extremely tired or weak without any apparent reason can be a symptom of advanced kidney cancer [15].

Other Possible Symptoms

While not as common, other symptoms that may be associated with type 2 papillary renal cell carcinoma include:

• A lump or mass in the side
• Unexplained fever
• Frequent or painful urination

It's essential to note that these symptoms can also be indicative of other conditions. If you're experiencing any of these warning signs, it's crucial to consult a healthcare professional for proper evaluation and diagnosis.

References: [3] - Context result 3: "Common symptoms include blood in the urine, pain, and feeling a mass in your side." [5] - Context result 5: "What are

Diagnostic Tests for Type 2 Papillary Adenoma of the Kidney

Type 2 papillary adenoma of the kidney is a rare and benign tumor that can be challenging to diagnose. However, several diagnostic tests can help identify this condition.

• Imaging studies: Imaging tests such as CT scans, MRI, or ultrasound are often used to detect renal tumors, including type 2 papillary adenomas [1]. These tests can help determine the size and location of the tumor.
• Biopsy: A biopsy is a procedure where a small sample of tissue is taken from the kidney and examined under a microscope. This test can confirm the presence of a tumor and provide information about its histological characteristics [2].
• Histopathological examination: Histopathological examination involves examining the tissue sample obtained through biopsy or surgery to determine the type of tumor present. In the case of type 2 papillary adenoma, this test can help confirm the diagnosis by identifying specific histological features such as a single layer of cells on papillae and low nuclear grade [3].
• Molecular testing: Molecular testing may be indicated in some cases to achieve a correct diagnosis for high-grade renal cell carcinomas with papillary architecture. However, its role in diagnosing type 2 papillary adenoma is less clear [4].

It's essential to note that the diagnostic process for type 2 papillary adenoma of the kidney can be complex and may involve multiple tests and procedures.

References:

[1] Zhou C, Ban X, Luo L, Shi C Abdom Radiol (NY) 2022 Nov ... (Search result 1)

[2] Sep 2, 2023 — Molecular testing is indicated to achieve the correct diagnosis for high grade renal cell caricnomas with papillary architecture. · Some may in ... (Search result 5)

[3] by R Alaghehbandan · 2020 · Cited by 30 — Most renal epithelial tumors can be diagnosed easily based on pure histologic findings with or without immunohistochemical examination. Furthermore, molecular testing may provide additional information to support the diagnosis. (Search result 6)

[4] Type 2 papillary renal cell carcinoma: Has a consistently better clinical outcome than clear cell RCC Has a diagnostic recurrent genetic abnormality Is heterogeneous and as currently defined likely encompasses more than one entity Usually forms a single layer of cells on papillae and is low nuclear grade (Search result 10)

Differential Diagnosis of Type 2 Papillary Adenoma of the Kidney

Type 2 papillary adenoma of the kidney is a rare and benign tumor that can be challenging to differentiate from malignant tumors. The differential diagnosis for type 2 papillary renal cell carcinoma (RCC) includes several entities, which are listed below:

• Clear Cell Renal Cell Carcinoma: This is the most common type of RCC, accounting for about 75% of all RCC cases. Clear cell RCC can be distinguished from type 2 papillary RCC by its nodular architecture and thick bands of muscle tissue.
• Papillary Growth and Voluminous Cytoplasm: Type 2 papillary RCC often demonstrates papillary growth and voluminous cytoplasm, which can be similar to clear cell RCC with TCEB1 mutation.
• Acquired Cystic Disease Associated Renal Cell Carcinoma (ACD-RCC): ACD-RCC is a type of RCC that occurs in patients with end-stage renal disease. It often has a different appearance than type 2 papillary RCC, but can be challenging to differentiate.
• Oncocytoma: Oncocytoma is a benign tumor that can be difficult to distinguish from type 2 papillary RCC based on imaging features alone.

Key Features for Differential Diagnosis

To accurately diagnose type 2 papillary adenoma of the kidney, it is essential to consider the following key features:

• Imaging Features: CT scans and other imaging modalities can help differentiate between type 2 papillary RCC and other entities.
• Demographic Data: Patient age, sex, and medical history can also provide clues for differential diagnosis.
• Histological and Immunohistochemical Features: A thorough examination of the tumor's histology and immunohistochemistry can help distinguish type 2 papillary RCC from other types of RCC.

References

[8] Zhou C, Ban X, Luo L, Shi C Abdom Radiol (NY) 2022 Nov;47(11):3838-3846. Epub [12] Kidney tumor - Type 2 (eosinophilic) papillary renal cell carcinoma: papillary architecture with pseudostratified layers of cells with abundant eosinophilic cytoplasm and atypical nuclei with prominent nucleoli ... Differential diagnosis. Acquired cystic disease associated RCC (ACD-RCC): occurs in setting of end stage renal disease, often has [13] Fig. 2. Differential diagnosis for type 2 papillary renal cell carcinoma. Clear cell renal cell carcinoma with TCEB1 mutation often demonstrates nodular architecture with intervening thick bands of muscle (A, H&E, 100x). Papillary growth and voluminous cytoplasm are common features in such cases (B, H&E, 200x).

Note: The references provided are based on the search results within the context.