obsolete recurrent adult brain tumor

Based on the provided context, it appears that there are several types of recurrent adult brain tumors that have been considered obsolete under the new WHO classification system.

• GB IDH-mutant: This type of glioblastoma has been reclassified as a subtype of glioblastoma, rather than a separate entity. [1][2]
• AA (Anaplastic Astrocytoma): This tumor type is no longer considered a distinct category, and its cases are now classified under other types of astrocytomas or glioblastomas. [3][4]
• Diffuse Astrocytoma: This term has been replaced by more specific subtypes, such as IDH-mutant astrocytomas. [5][6]
• Anaplastic Pleomorphic Xanthoastrocytoma (APXA): This rare tumor type is now considered a subtype of pleomorphic xanthoastrocytoma, rather than a separate entity. [7]

It's essential to note that these obsolete classifications do not necessarily imply a change in the clinical behavior or treatment approach for patients with these tumors. However, they reflect updates in our understanding and classification of brain tumors.

References:

[1] WHO CNS5 (2021) - This reference is cited by 7940 times. [2] Louis DN et al. (2021) - Cited by 7940 times. [3] Schneider T et al. (2010) - Cited by 178 times. [4] Johnson DR et al. (2022) - Cited by 29 times. [5] Park YW et al. (2023) - Cited by 36 times. [6] Willman M et al. (2023) - Cited by 5 times. [7] Louis DN et al. (2021) - Cited by 7940 times.

Based on the provided context, here are some common signs and symptoms associated with an obsolete recurrent adult brain tumor:

• Headaches: These can be a persistent or recurring issue for individuals with brain tumors (1, 8).
• Seizures: As many as half of people with brain tumors will experience seizures at some point, which may be the first sign of a brain tumor (14, 15).
• Weakness: Patients with brain tumors often experience weakness, which can manifest in various ways depending on the location and severity of the tumor (1, 12).
• Changes in speech, memory, or personality: These cognitive changes are common symptoms of brain tumors, particularly those affecting the frontal lobe or temporal lobe (7, 12).
• Difficulty walking: As a result of weakness or paralysis, individuals with brain tumors may experience difficulty walking or maintaining balance and coordination (8, 12).
• Blurry vision: Tumors in different parts of the brain can cause visual disturbances, including blurry vision (8, 12).
• Nausea and vomiting: These symptoms are often associated with elevated intracranial pressure, which can be a result of a brain tumor (4, 8).

It's essential to note that these symptoms may not necessarily indicate an obsolete recurrent adult brain tumor, as they can also be caused by other conditions. A proper medical diagnosis is necessary for accurate identification and treatment.

References:

1. J Park · 2022
2. SM Chang · Cited by 3
3. A PERKINS · 2016 · Cited by 262
4. L Dirven · 2015 · Cited by 13
5. SM Chang · Cited by 3
6. M Cohn · 2014 · Cited by 4
7. JMC Noble · 2005 · Cited by 12
8. H Australia · 2024
9. Aug 19, 2024
10. Ultimately, the signs and symptoms of cancer death will be different for every person...
11. A recurrence is when your tumor begins to grow or has come back.
12. Brain tumors may be malignant (brain cancer) or benign.
13. Tumor recurrence is always a possibility.
14. As many as half of people with brain tumors will have seizures at some point.
15. When brain cancer comes back, it is known as a brain tumor recurrence.

Based on the provided context, it appears that there are various diagnostic tests used to diagnose and evaluate adult brain tumors. Here are some of the relevant tests mentioned:

• Imaging tests: Computed Tomography (CT) scans, Magnetic Resonance Imaging (MRI), and other MRI sequences can help pinpoint brain tumors and plan surgical resection [7]. Contrast is often used in these imaging tests to enhance visibility [8].
• Physical exam and history: A physical examination and medical history can provide important information about the patient's overall health and potential symptoms related to a brain tumor [3].
• Eye tests: Eye tests, such as identifying swelling of the optic disc or pressure on the optic nerve, can diagnose a brain tumor [9].

It is worth noting that the context also mentions that certain factors can affect the outlook (prognosis) after a brain or spinal cord tumor diagnosis [4]. However, this information does not seem directly related to diagnostic tests.

In terms of obsolete recurrent adult brain tumor diagnostic tests, it's difficult to say without more specific information. However, based on the context provided, it appears that some older imaging techniques may have been replaced by newer technologies like MRI and CT scans.

Relevant tests for diagnosing adult brain tumors:

• Imaging tests (CT, MRI)
• Physical exam and history
• Eye tests

Note: The context does not provide specific information about obsolete diagnostic tests. If you would like me to search again or ask something else, please let me know!

Treatment Options for Recurrent Adult Brain Tumors

Recurrent adult brain tumors can be challenging to treat, and the approach often depends on the type of tumor and its location. While surgery and radiation therapy are still considered effective options, drug treatments have also become increasingly important in managing these cases.

• Chemotherapy: This treatment involves using medications to kill cancer cells. Chemotherapy may be used alone or in combination with other therapies, such as radiation therapy.
• Targeted Therapy: Targeted drugs work by targeting specific molecules that help cancer cells grow and divide. Bevacizumab (Avastin) is an example of a targeted drug that has been approved for treating recurrent glioblastoma patients.
• Immunotherapy: This type of treatment uses the body's immune system to fight cancer. Immunotherapies, such as selinexor, have shown promise in reducing tumor size and improving patient outcomes.

Emerging Treatments

Recent studies have explored new treatments for recurrent adult brain tumors, including:

• Vorasidenib: This targeted therapy has demonstrated positive results in delaying progression of a specific form of glioma.
• Sacituzumab Govitecan: A novel treatment that has shown promise in treating recurrent brain tumors.

Treatment Planning

A team of doctors typically plans each person's treatment individually, taking into account the type of tumor, its location, and other factors. The goal is to provide the best chance of treating the tumor while minimizing side effects.

References:

• [1] Targeted drugs don't yet play a large role in treating brain or spinal cord tumors, but some of them might be helpful for certain types of tumors.
• [3] by HS Birk · 2017 · Cited by 65 — However, mounting evidence describes the role of re-resection, bevacizumab, chemotherapy, targeted molecular therapies, immunotherapeutic approaches and ...
• [4] A targeted therapy drug called vorasidenib had positive results in delaying progression of a specific form of glioma, a slow-growing but deadly brain cancer.
• [5] by MA Vaz-Salgado · 2023 · Cited by 29 — Bevacizumab is a recombinant humanized monoclonal antibody that binds to the circulating vascular endothelial growth factor (VEGF). It is composed of human ...
• [9] Targeted drug therapy is increasingly used to treat brain tumors. Typically, it is used alongside a combination of surgery, chemotherapy, and radiation therapy.
• [10] Adult central nervous system tumor treatment options include surgery, radiosurgery, radiation therapy, chemotherapy, surveillance, and supportive care.