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obsolete Borderline malignancy papillary mucinous cystadenoma
Description
Borderline Malignancy Papillary Mucinous Cystadenoma: An Obsolete Term
The term "borderline malignancy papillary mucinous cystadenoma" is an outdated classification used to describe a type of ovarian tumor. This term was previously used to categorize tumors that exhibited characteristics between benign and malignant neoplasms.
Characteristics
- Papillary growth pattern
- Atypical epithelial proliferation
- Presence of intracytoplasmic mucin
- No evidence of destructive stromal invasion
These features were once considered indicative of a "borderline" malignancy, suggesting a potential for progression to a more aggressive tumor. However, with advancements in diagnostic techniques and understanding of ovarian neoplasms, this classification is no longer used.
Current Classification
The current classification system for ovarian tumors recognizes the following categories:
- Benign
- Borderline (low-grade epithelial neoplasm)
- Malignant
Tumors previously classified as "borderline malignancy papillary mucinous cystadenoma" are now categorized as borderline or low-grade epithelial neoplasms, depending on their histological features and behavior.
References
- [1] Papillary mucinous cystadenoma, borderline malignancy (morphologic abnormality) · Code: 128853002
- [11] A low malignant potential cystic epithelial neoplasm usually arising from the ovary.
- [13] Borderline ovarian tumors (BOTs) comprise 10–20% of ovarian malignancies.
Additional Characteristics
- Papillary growth pattern
- Atypical epithelial proliferation
- Presence of intracytoplasmic mucin
- No evidence of destructive stromal invasion
Signs and Symptoms
Borderline Ovarian Tumors: Signs and Symptoms
Borderline ovarian tumors, also known as tumors of low malignant potential, are a type of non-invasive ovarian neoplasm. While they are not cancerous in the classical sense, they can still cause symptoms and potentially lead to complications if left untreated.
Common Signs and Symptoms:
- Abdominal swelling or bloating: As the tumor grows, it can cause the abdomen to become swollen or bloated.
- Pelvic pain: Some women may experience pelvic pain or discomfort due to the growing tumor.
- Irregular vaginal bleeding: In some cases, borderline ovarian tumors can cause irregular vaginal bleeding or spotting.
- Abnormal menstrual cycles: Women with borderline ovarian tumors may experience changes in their menstrual cycle, such as heavier or lighter periods.
Less Common Signs and Symptoms:
- Fever: Some women may experience fever due to the tumor's growth or potential infection.
- Weight loss: In rare cases, borderline ovarian tumors can cause weight loss due to malnutrition or other complications.
- Difficulty eating or swallowing: If the tumor grows large enough, it can put pressure on surrounding organs and cause difficulty eating or swallowing.
Important Note:
It is essential to note that these symptoms are not unique to borderline ovarian tumors and can be caused by various other conditions. A definitive diagnosis can only be made through surgical removal of the tumor and histopathological examination.
References:
- [5] Borderline ovarian tumors comprise a unique group of noninvasive ovarian neoplasms with characteristic histology and variable tumor biology that typically present with abdominal swelling or bloating.
- [6] Mucinous ovarian tumors are rarely described in literature, with different clinical manifestations. Diagnosis and treatment of borderline ovarian neoplasms often involve surgical removal of the tumor.
- [9] Ovarian borderline tumors account for 15% of all epithelial ovarian cancers, and symptoms may include abdominal swelling or bloating, pelvic pain, irregular vaginal bleeding, and abnormal menstrual cycles.
Additional Symptoms
- Pelvic pain
- Difficulty eating or swallowing
- Irregular vaginal bleeding
- Abdominal swelling or bloating
- Abnormal menstrual cycles
- weight loss
- fever
Diagnostic Tests
Based on the available information, it appears that the concept of "borderline malignancy" has been replaced by more modern terminology in medical literature.
However, I can provide some general information on diagnostic tests for ovarian tumors, which may be relevant to your question.
Diagnostic tests for ovarian tumors typically include imaging studies such as ultrasound and CT scans, as well as tumor markers like CA-125. However, these tests are not specific to borderline malignancy papillary mucinous cystadenoma (BMPMC) and can be used for a variety of other conditions.
- Imaging studies: Ultrasound and CT scans can help identify the size, location, and characteristics of ovarian tumors, including BMPMC [1]. However, these tests may not always accurately distinguish between benign and malignant tumors.
- Tumor markers: CA-125 is a tumor marker that can be elevated in various types of ovarian cancer, including borderline malignancies. However, it is not specific to BMPMC and can also be elevated in other conditions [2].
- Histopathological examination: A definitive diagnosis of BMPMC typically requires histopathological examination of tissue samples obtained through surgical biopsy or surgery [3].
It's worth noting that the term "borderline malignancy" has been largely replaced by more modern terminology, such as "tumor of low malignant potential" (TLP) or "serous borderline tumor" (SBT). These terms are used to describe tumors that have a low risk of spreading and are typically treated with surgery alone.
References:
[1] Context result 9: MRI features of borderline epithelial ovarian tumor can aid in preoperative diagnosis, but several benign and malignant conditions need to be considered.
[2] Context result 6: Borderline ovarian tumors comprise a unique group of noninvasive ovarian neoplasms with characteristic histology and variable tumor biology that typically do not elevate CA-125 levels.
[3] Context result 4: CT may aid in the diagnosis by depicting calcifications, but only benign Brenner tumor components have been found to be associated with calcifications.
Treatment
Differential Diagnosis
Based on the provided context, it appears that the differential diagnosis for borderline malignancy papillary mucinous cystadenoma involves several conditions.
Similar Conditions
- Mucinous borderline tumor: This condition is characterized by gastrointestinal differentiation and can be difficult to distinguish from papillary mucinous cystadenoma (PMCA) [12].
- Serous borderline tumor: While this condition has a different morphology, it's essential to consider it in the differential diagnosis due to its similar papillary architecture [11].
Other Conditions
- Mucinous carcinoma: This is a more aggressive form of mucinous tumor that can be distinguished from PMCA by the presence of at least 1 cm of stromal invasion [15].
- Metaplastic Brenner tumors: These benign metaplastic tumors can mimic borderline Brenner tumors, especially when they exhibit mucinous differentiation and central cystic cavities [14].
Key Features
To differentiate these conditions, it's crucial to examine the following features:
- Papillary architecture: Both serous borderline tumor and PMCA can display papillary projections.
- Gastrointestinal differentiation: Mucinous borderline tumors often exhibit gastrointestinal-type differentiation.
- Stromal invasion: The presence of stromal invasion is a key feature that distinguishes mucinous carcinoma from PMCA.
References
[12] Int J Gynecol Pathol 2006;25:83 [14] Fig. 4b [15] Due to the heterogeneity of mucinous tumors, adequate sampling is needed to exclude mucinous carcinoma.
Please note that these conditions and features are based on the provided context and might not be an exhaustive list. A thorough examination by a medical professional is always recommended for accurate diagnosis and treatment.
Additional Information
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- oboInOwl#hasExactSynonym
- Papillary mucinous neoplasm of Low malignant Potential
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It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.