cervical adenoma malignum

Common Signs and Symptoms of Cervical Adenoma Malignum

Cervical adenoma malignum (AM) is a rare type of cancer that affects the cervix. The major clinical symptoms of AM are:

• Profuse mucoid vaginal discharge: This is one of the most common presenting symptoms, as reported in several studies [6][7][9].
• Irregular/contact vaginal bleeding: Women with AM may experience abnormal vaginal bleeding, which can be heavy and have a foul odor [6][7][9].
• Abnormal vaginal discharge: The major symptoms caused by secretion of the tumor itself are the most characteristic of AM [8].

Other possible symptoms include:

• Vaginal bleeding after intercourse, between periods or after menopause
• Menstrual bleeding that is heavier and lasts longer than usual
• Watery, bloody vaginal discharge that may be heavy and have a foul odor

It's essential to note that these symptoms can also be caused by conditions other than cervical cancer. If you experience any of these symptoms, it's crucial to consult with your healthcare professional for proper evaluation and diagnosis.

References:

[6] EY Ki · 2013 · Cited by 28 — The major clinical symptoms of AM are profuse mucoid vaginal discharge and irregular/contact vaginal bleeding [5,7]. [7] This tumour has been described in several case series, and in these cases the most common symptoms were profuse mucinous vaginal discharge and vaginal bleeding. [8] by KT Lim · 2012 · Cited by 32 — The major symptoms of AM are abnormal vaginal discharge and vaginal bleeding. The symptoms caused by secretion of the tumor itself are the most characteristic ... [9] by EY Ki · 2013 · Cited by 28 — The major clinical symptoms of AM are profuse mucoid vaginal discharge and irregular/contact vaginal bleeding[5, 7].

Diagnostic Tests for Cervical Adenoma Malignum

Cervical adenoma malignum, a rare variant of uterine cervical cancer, can be challenging to diagnose. However, several diagnostic tests can help identify this condition.

• Pap Smear: A cytological diagnosis of adenoma malignum based on a Papanicolaou smear is rarely made [3]. The detection rate of Pap smear for adenoma malignum is low, at 7.6% [1].
• Deep Biopsy (Cone Biopsy or Endocervical Curettage): A deep biopsy can provide an accurate diagnosis of adenoma malignum. The 5-year survival rate after a deep biopsy is high, at 88.8% [3].
• Magnetic Resonance Imaging (MRI): MRI findings are characteristic and may be useful in early diagnosis [4]. On T1-weighted images, the lesion is isointense to slightly hyperintense relative to the uterus, while on T2-weighted images, it is markedly hyperintense [9].
• PET CT Scan: A PET CT scan can also be used for medical imaging prior to treatment [8].

Immunohistochemical Examination

In addition to these diagnostic tests, immunohistochemical examination can be helpful in the differential diagnosis of multicystic cervical lesions. HIK-1083 and CEA recognize the mucous cells of the adenoma malignum [5].

It's essential to note that a combination of these diagnostic tests may provide a more accurate diagnosis of cervical adenoma malignum.

References: [1] - Search result 1 [2] - Not applicable (no relevant information) [3] - Search result 3 [4] - Search result 4 [5] - Search result 5 [8] - Search result 8 [9] - Search result 9

Differential Diagnosis of Cervical Adenoma Malignum

Cervical adenoma malignum, also known as minimal deviation adenocarcinoma (MDA), is a rare variant of adenocarcinoma of the uterine cervix. When considering differential diagnosis for this condition, several factors and symptoms come into play.

• Peutz-Jeghers syndrome: Adenoma malignum is often associated with Peutz–Jeghers syndrome, a genetic disorder characterized by the growth of polyps in the gastrointestinal tract and an increased risk of certain cancers. [4]
• Mucinous tumors of the ovary: This condition can also be linked to mucinous tumors of the ovary, which are a type of ovarian cancer. [1-4]
• Watery vaginal discharge: The most common initial symptom of adenoma malignum is watery vaginal discharge, making it essential to consider this tumor in the differential diagnosis of such symptoms. [5]

Imaging and Diagnostic Tools

In addition to clinical evaluation, various imaging and diagnostic tools can aid in the differential diagnosis of cervical adenoma malignum:

• MRI appearance: MRI can be helpful in identifying the characteristics of adenoma malignum, although its appearance may not always be typical. [3]
• CEA and HIK-1083 immunohistochemistry: Immunohistochemical examination using CEA and HIK-1083 can aid in the differential diagnosis of multicystic cervical lesions. [7]

References

1. SB Park (2011) - Adenoma malignum is often associated with Peutz–Jeghers syndrome and mucinous tumors of the ovary.
2. EY Ki (2013) - Adenoma malignum (AM) of the cervix is a rare disease and it is difficult to diagnose due to the deceptively benign appearance of the tumor cells.
3. by E Shirali (2021) - At this moment, adenoma malignum was considered as a main differential diagnosis that suggested by consultant radiologist. MRI appearance of ...
4. SB Park (2011) - Adenoma malignum is often associated with Peutz–Jeghers syndrome and mucinous tumors of the ovary.
5. Despite being a rare cervical tumour, adenoma malignum should be considered in the differential diagnosis of watery vaginal discharge.
6. by EY Ki (2013) - Adenoma malignum (AM) of the cervix is a rare disease and it is difficult to diagnose due to the deceptively benign appearance of the tumor cells.
7. by AC Senar (2016) - Immunohistochemical examination can be helpful in the differential diagnosis of multicystic cervical lesions. HIK-1083 and CEA recognize the mucous cells of ...
8. by KT Lim (2012) - Adenoma malignum (AM) is a rare variant of adenocarcinoma of the uterine cervix. AM comprises 1–3% of all cervical adenocarcinomas.
9. by M Sui (2016) - Minimal deviation adenocarcinoma (MDA) or cervical adenoma malignum (AM) is a subtype of cervical mucinous adenocarcinoma [1,2] and accounts for only 1 to 3 ...