obsolete malignant neoplasm of nipple

Obsolete Terms for Malignant Neoplasm of Nipple

The term "malignant neoplasm of nipple" was previously used to describe a type of cancer that affects the nipple and surrounding area. However, this term is now considered outdated and has been replaced by more specific and accurate terminology.

• ICD-10: C50.019 - malignant neoplasm of nipple and areola, unspecified female breast
• ICD-11: 2E65.5 & XH3E21 - Paget disease of nipple and Paget disease, respectively

These codes indicate that the condition is now classified as a specific type of cancer, such as Paget's disease of the breast or ductal carcinoma in situ (DCIS).

Historical Context

In the past, the term "malignant neoplasm of nipple" was used to describe a range of conditions, including cancers and other abnormal growths. However, this term is no longer used in modern medical practice due to its lack of specificity and accuracy.

• [1] Malignant neoplasm of breast. Malignant tumor of breast.
• [3] Breast neoplasm. Nipple neoplasm. Benign Nipple Neoplasm. Adenoma of nipple; Infiltrating nipple syringomatous adenoma; Malignant Nipple Neoplasm.

These references indicate that the term "malignant neoplasm of nipple" was previously used to describe a range of conditions, including both benign and malignant tumors.

Current Terminology

Today, the condition is more accurately described as:

• Paget's disease of the breast: A rare form of ductal carcinoma in situ (DCIS) that affects the skin of the nipple or surrounding area.
• Ductal carcinoma in situ (DCIS): A type of non-invasive cancer that affects the milk ducts of the breast.

These terms are more specific and accurate than the outdated term "malignant neoplasm of nipple".

Warning Signs of Nipple Cancer

Nipple cancer, also known as Paget's disease of the nipple, is a rare but aggressive form of breast cancer that affects the skin of the nipple and sometimes the areola. The symptoms of nipple cancer can be subtle and may not always be noticeable in the early stages. However, there are some warning signs to look out for:

• Changes in the nipple: This can include changes in shape, size, or color of the nipple, such as crusting, sores, redness, or inversion (where the nipple turns inward) [1][9].
• Skin changes: The skin around the nipple and areola may become thickened, red, or scaly, giving it an "orange-peel" texture [10].
• Dimpling or puckering: The breast skin may develop dimples or puckers, which can be a sign of cancer [10].
• Discharge from the nipple: While rare, nipple discharge can be a symptom of nipple cancer [12][14].
• Itchy, scaly sore or rash: An itchy, scaly sore or rash on the nipple or areola area may also be a warning sign [12].

Important Note

It's essential to remember that these symptoms can also be caused by benign (non-cancerous) breast conditions. If you notice any of these changes, it's crucial to consult with your doctor for proper evaluation and diagnosis.

References:

[1] Context result 2: Signs and symptoms · has become turned in · has changed shape · is leaking (has a discharge) · bleeds · has a rash or has crusted, flaky skin. [9] Context result 9: a change in the size or shape of one or both breasts; a change in the shape or appearance of the nipple, such as crusting, sores, redness or inversion (where ... [10] Context result 10: Breast cancer symptoms may include: Lump or mass in the breast; Lump or mass in the armpit; Breast skin changes, including skin redness and thickening of the breast skin, resulting in an orange-peel texture; Dimpling or puckering on the breast; Discharge from the nipple; Scaliness on nipple, which sometimes extends to the areola [12] Context result 12: Itchy, scaly sore or rash on the nipple; Pulling in of the nipple (inverted nipple) or other parts of the breast; Nipple discharge (rare) These may also be signs of a benign (not cancer) breast condition. [14] Context result 14: Potential warning signs to keep an eye out for include: Nipple Changes. Changes to your nipples that warrant a call to your doctor include: New asymmetry: the shape or size of a nipple changes in any way; Retracted/inverted or flat nipple: the normally raised tissue of the nipple flattens or even appears to be drawn into to the breast

Based on the provided context, it appears that you are looking for diagnostic tests related to an obsolete malignant neoplasm of the nipple.

According to search result [8], a small tissue sample will be taken from your nipple or the skin around it. The sample will be examined under a microscope and tested to see if it's cancerous. This suggests that a biopsy is a relevant diagnostic test for evaluating a malignant neoplasm of the nipple.

Additionally, search result [5] mentions that a biopsy is the only definite way to diagnose breast cancer, which implies that a biopsy may also be used to diagnose a malignant neoplasm of the nipple.

Furthermore, search result [10] discusses imaging tests for breast cancer in men, but it does not specifically mention diagnostic tests for a malignant neoplasm of the nipple. However, it does mention a mammogram as an imaging test that can help doctors look for changes in breast tissue.

It's worth noting that search results [1-4, 6-9, 11-14] discuss various aspects of breast cancer diagnosis and treatment, but they do not specifically address diagnostic tests for a malignant neoplasm of the nipple.

In summary, based on the provided context, it appears that a biopsy is a relevant diagnostic test for evaluating a malignant neoplasm of the nipple. However, further information may be needed to provide a more comprehensive answer.

Relevant Diagnostic Tests:

• Biopsy (search result [8])
• Mammogram (search result [10])

Additional Information:

• A biopsy is the only definite way to diagnose breast cancer (search result [5])
• Imaging tests, such as mammograms, can help doctors look for changes in breast tissue (search result [10])

Based on the provided context, it appears that you are looking for information on the drug treatment of breast cancer, specifically focusing on the nipple.

• The nipple is a part of the breast where milk ducts open to the skin. Breast cancer can occur in this area.
• According to search result [11], breast cancer treatment often starts with surgery to remove the cancer. Most people with breast cancer will have other treatments after surgery, such as radiation, chemotherapy, and hormone therapy.

Regarding drug treatment specifically targeting the nipple, there is limited information available in the provided context. However, it's worth noting that some breast cancers can be treated with targeted therapies that focus on specific proteins or receptors involved in cancer growth.

• For example, if your breast cancer is HER2 positive, targeted therapy, usually a medicine called trastuzumab, can be used to treat the cancer by stopping the growth of these cells [4].
• Additionally, some breast cancers may express other targets such as PI3K/AKT pathway or estrogen receptor (ER) and progesterone receptor (PR), which can also be targeted with specific drugs.

However, it's essential to consult a healthcare professional for personalized advice on treatment options. They will assess your individual situation and provide guidance based on the most current medical knowledge.

In terms of drug treatment specifically targeting the nipple, there is limited information available in the provided context. However, some breast cancers can be treated with targeted therapies that focus on specific proteins or receptors involved in cancer growth.

• For example, if your breast cancer is HER2 positive, targeted therapy, usually a medicine called trastuzumab, can be used to treat the cancer by stopping the growth of these cells [4].
• Additionally, some breast cancers may express other targets such as PI3K/AKT pathway or estrogen receptor (ER) and progesterone receptor (PR), which can also be targeted with specific drugs.

However, it's essential to consult a healthcare professional for personalized advice on treatment options. They will assess your individual situation and provide guidance based on the most current medical knowledge.

References:

[4] - Targeted therapy – if your breast cancer is HER2 positive, targeted therapy, usually a medicine called trastuzumab, can be used to treat the cancer by stopping the growth of these cells. [11] - Treatment. Breast cancer treatment often starts with surgery to remove the cancer. Most people with breast cancer will have other treatments after surgery, such as radiation, chemotherapy and hormone therapy. Some people may have chemotherapy or hormone therapy before surgery. These medicines can help shrink the cancer and make it easier to remove.

Differential Diagnosis of Malignant Neoplasm of Nipple

The differential diagnosis of a malignant neoplasm of the nipple involves ruling out other conditions that may present with similar symptoms. Some of these conditions include:

• Papilloma: A benign tumor that can cause nipple discharge or a palpable mass.
• Ductal carcinoma: A type of breast cancer that can cause nipple discharge or a lump behind the nipple.
• Fibrocystic disease: A non-cancerous condition that can cause lumps or thickening in the breast tissue, which may be mistaken for a malignant neoplasm.
• Erosive adenomatosis (EAN): A rare benign tumor that can cause erosions on the nipple and areola, which may be mistaken for a malignant neoplasm.

According to [10], EAN is a rare disease that clinicians must be aware of in patients with erosive lesions of the nipple. The main concern is ruling out malignant proliferations in the differential diagnosis.

In addition, other conditions such as eczema and inverted nipple may also need to be ruled out in the differential diagnosis of a malignant neoplasm of the nipple [7].

It's worth noting that most women diagnosed with Paget's disease of the nipple have an underlying ductal breast cancer, either in situ or invasive [3]. Therefore, a thorough evaluation and diagnostic workup are essential to rule out other conditions and confirm the diagnosis.

References:

[1] - [15] are search results containing information on differential diagnosis of malignant neoplasm of nipple.