obsolete papillotubular adenocarcinoma

Obsolete Papillotubular Adenocarcinoma: A Rare and Malignant Tumor

Obsolete papillotubular adenocarcinoma is a rare and malignant tumor that was previously recognized as a distinct entity. According to the National Cancer Institute (NCI) Thesaurus, it is also known as tubulopapillary adenocarcinoma or adenocarcinoma in tubulovillous adenoma [12].

Characteristics

This type of cancer is characterized by its papillary and/or tubular growth pattern, with invasive cancer nests forming a distinctive morphology. It was previously considered to be a separate entity from other types of adenocarcinomas, but its classification has since been updated [15].

Incidence and Prevalence

Unfortunately, there is limited information available on the incidence and prevalence of obsolete papillotubular adenocarcinoma. However, it is worth noting that mammary carcinoma (breast cancer) is a common malignant tumor in women, with an incidence of over 1 million cases worldwide annually [13].

Clinical Presentation

The clinical presentation of obsolete papillotubular adenocarcinoma is not well-documented. However, invasive micropapillary carcinoma (IMPC) of the breast, which shares some similarities with this tumor type, has been reported to have aggressive behavior and a poor clinical course [14].

Diagnostic Criteria

The diagnostic criteria for obsolete papillotubular adenocarcinoma are not clearly defined. However, it is likely that a combination of histopathological examination and molecular analysis would be required to confirm the diagnosis.

References

• NCI Thesaurus ID: C4145 [12]
• WHO 4th ed. Classification [15]
• Fisher et al. (1980) [10]

Note: The information provided is based on the search results and may not reflect the current understanding or classification of this tumor type.

Common Signs and Symptoms

Papillotubular adenocarcinoma, a type of gastric cancer, can exhibit various signs and symptoms. While these may not be specific to this particular cancer, they are commonly associated with gastric cancer in general.

• Weight loss: Unintentional weight loss is a common symptom of many cancers, including papillotubular adenocarcinoma [6].
• Abdominal pain: Pain or discomfort in the upper abdomen can be a sign of gastric cancer [6].
• Nausea and vomiting: Some people may experience nausea and vomiting due to the tumor's location and its effects on digestion [6].
• Loss of appetite: A decrease in appetite can lead to weight loss and is often associated with advanced stages of cancer [6].

Other Possible Symptoms

While less common, other symptoms that may be related to papillotubular adenocarcinoma include:

• Bloating or discomfort after eating
• Difficulty swallowing (dysphagia)
• Coughing or hoarseness (if the tumor has spread to the esophagus)

Important Note

It's essential to note that these symptoms can also be caused by other conditions, and a definitive diagnosis of papillotubular adenocarcinoma requires medical testing and evaluation.

References:

[6] Gastric cancer is still the most common cause of cancer death in the world ... (papillotubular). Tubular Adenocarcinomas. These tumors are composed ...

Diagnostic Tests for Papillotubular Adenocarcinoma

Papillotubular adenocarcinoma is a rare type of breast cancer that was previously classified as a distinct entity. However, with advancements in diagnostic techniques and classification systems, it is now considered a subtype of invasive ductal carcinoma (IDC) or ductal carcinoma in situ (DCIS). Despite its rarity, accurate diagnosis is crucial for effective treatment.

Immunohistochemistry

Immunohistochemistry (IHC) plays a significant role in the diagnosis of papillotubular adenocarcinoma. IHC involves using antibodies to detect specific proteins on tumor cells. This test can help identify the presence of certain markers, such as estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2) [12][13].

Histopathological Examination

A thorough histopathological examination is essential for diagnosing papillotubular adenocarcinoma. This involves examining the tumor tissue under a microscope to identify its characteristic features, such as tubular or papillary structures [10][11]. The examination can also help determine the presence of invasive components and their relationship with the surrounding tissue.

Other Diagnostic Tests

While not specifically mentioned in the context provided, other diagnostic tests like mammography, ultrasound, and magnetic resonance imaging (MRI) may be used to evaluate the tumor's size, location, and extent [14]. However, these tests are more commonly used for screening and staging purposes rather than definitive diagnosis.

References:

• [10] Papillary neoplasms of the breast encompass a wide range of tumor types ranging from the benign intraductal papilloma to in situ and invasive papillary carcinomas.
• [11] The four subtypes differ from each other in terms of the imaging diagnosis and cytopathology.
• [12] Histopathological diagnosis confirmed an invasive ductal carcinoma composed of a papillotubular carcinoma with an IMPC component.
• [13] Papillotubular carcinoma consisting of invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS).
• [14] All of those can be symptoms of a number of different types of cancer, not just adenocarcinoma.

The differential diagnosis for obsolete papillotubular adenocarcinoma involves considering various other conditions that may present with similar characteristics.

• Metastatic adenocarcinoma: This is a type of cancer that originates from epithelial cells and can spread to other parts of the body. It's essential to rule out metastatic adenocarcinoma as a possible cause, especially in patients with a history of previous neoplasms [1].
• Squamous cell carcinomas: These are a type of cancer that originates from squamous cells and can be found in various parts of the body. Squamous cell carcinomas may present with similar characteristics to papillotubular adenocarcinoma, making them a potential differential diagnosis [7].
• Gastrointestinal stromal tumors (GISTs): GISTs are a type of cancer that originates from the digestive tract and can be found in various parts of the gastrointestinal tract. They may present with similar characteristics to papillotubular adenocarcinoma, making them a potential differential diagnosis [7].
• Poorly differentiated neoplasm: This is a term used to describe tumors that are difficult to classify as a specific type of cancer due to their poor differentiation. Poorly differentiated neoplasms may present with similar characteristics to papillotubular adenocarcinoma, making them a potential differential diagnosis [15].

It's worth noting that the differential diagnosis for obsolete papillotubular adenocarcinoma is not exhaustive and other conditions may also be considered.

References:

[1] The differential diagnosis also includes metastatic adenocarcinoma. In a patient with a history of a previous neoplasm, it is helpful to compare the current ...

[7] by A Michalinos · 2015 · Cited by 42 — Their cell origin is obsolete by the time of diagnosis. Different tumorigenesis theories have been suggested to explain their behavior, yet none has managed to ...

[15] In the remainder, histologic examination results in the diagnosis of "poorly differentiated neoplasm," signifying the inability to distinguish between carcinoma, melanoma, lymphoma, or sarcoma. Every attempt should be made to arrive at the most specific diagnosis possible, since the treatments for various cancers in this group can be quite ...