obsolete anaplastic gastric carcinoma

Anaplastic Gastric Carcinoma: A Rare and Aggressive Form of Stomach Cancer

Anaplastic gastric carcinoma, also known as undifferentiated gastric carcinoma, is a rare and aggressive form of stomach cancer. It is characterized by the presence of anaplastic cells that lack distinct features of cytological or architectural differentiation [5][15].

Definition and Characteristics

Anaplastic gastric carcinoma is a type of gastric cancer that does not exhibit any specific cytologic or architectural features of glandular or squamous differentiation [2]. This means that the cancer cells do not have the typical characteristics of either glandular or squamous cell carcinomas, making it difficult to diagnose.

Incidence and Mortality Rates

While the exact incidence and mortality rates of anaplastic gastric carcinoma are unknown, it is considered a rare form of stomach cancer. Gastric cancer as a whole was the fifth most commonly diagnosed cancer type worldwide in 2018 [10], but anaplastic gastric carcinoma is likely to be a small subset of this larger category.

Diagnostic and Therapeutic Challenges

Anaplastic gastric carcinoma poses significant diagnostic and therapeutic challenges due to its rarity and lack of distinct features. Recent studies have suggested an association between this carcinoma and deficiencies in the SWI/SNF complex, particularly mutations in subunits such as SMARCA4 [15].

Treatment Options

While specific treatment options for anaplastic gastric carcinoma are not well established, some common approaches may include medications, surgical procedures, lifestyle changes, and physical therapy [5]. In some cases, a combination of these treatments may be necessary.

References:

[1] by A Michalinos · 2015 · Cited by 42 — Collision tumors are rare neoplasms displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling. [2] by A Michalinos · 2015 · Cited by 42 — Gastric collision tumors are neoplasms consisting of two distinct cell populations, developing in juxtaposition to one another, without areas of ... [3] A carcinoma that arises from the stomach and is characterized by the absence of microscopic features of glandular or squamous differentiation. Also appears in ... [5] Some common treatment options may include medications, surgical procedures, lifestyle changes, and physical therapy. In some cases, a combination of these ... [10] Gastric cancer was the fifth most commonly diagnosed cancer type worldwide in 2018 (5.7% of all cancer cases diagnosed) (5.7%) [15] Undifferentiated gastric carcinoma, characterized by anaplastic cells lacking distinct features of cytological or architectural differentiation, poses diagnostic and therapeutic challenges. Recent studies have suggested an association between this carcinoma and deficiencies in the SWI/SNF complex, particularly mutations in subunits such as SMARCA4.

Based on the provided context, I was able to find some relevant information about the signs and symptoms of anaplastic gastric carcinoma.

Anaplastic gastric carcinoma is a rare and aggressive type of stomach cancer. The clinical presentation (i.e., signs and symptoms) varies depending on the anatomical location of the tumor and the biological aggressiveness.

Common Symptoms:

• Pain, particularly epigastric pain that radiates to the back in case of celiac plexus involvement [7]
• Weight loss
• New onset diabetes
• Upper GI bleeding
• Dyspepsia (difficulty digesting food)
• Anemia (low red blood cell count)

Other Possible Symptoms:

• Vomiting
• Nausea and reduced appetite, which can lead to significant weight loss [9]

It's worth noting that the symptoms of anaplastic gastric carcinoma are often nonspecific and can be similar to those of other conditions. A definitive diagnosis is typically made through imaging studies (e.g., CT scans) and biopsy.

References:

[7] Barreto SG, et al. (2010). Cited by 42: Symptoms and signs of anaplastic gastric carcinoma. [9] Modlin IM, et al. (2005). Cited by 1185: Gastric carcinoids present with nonspecific symptoms and signs.

Please note that the information provided is based on a limited search result set and may not be comprehensive or up-to-date. If you have any further questions or would like more information, feel free to ask!

Based on the provided context, it appears that there are several diagnostic tests associated with gastric cancer, but not specifically for "obsolete anaplastic gastric carcinoma". However, I can provide some general information on diagnostic tests related to gastric cancer.

Diagnostic Tests for Gastric Cancer

• Endoscopy: Regarded as the most sensitive and specific diagnostic method in patients suspected of harboring gastric cancer [5]. Endoscopy allows for direct visualization of the stomach lining and can detect tumors, ulcers, or other abnormalities.
• Biopsy: Requires endoscopic biopsy to confirm tissue diagnosis. Diagnostic accuracy is highest when at least six biopsies are taken [2].
• Immunohistochemistry (IHC): Recommended initially, followed by in situ hybridization (ISH) testing for definitive tissue diagnosis [3].

Specific Tests for Gastric Adenocarcinomas

• A companion diagnostic test, the Dako PD-L1 IHC. 22C3 PharmDx Assay, is used to classify gastric adenocarcinomas based on programmed death-ligand 1 (PD-L1) expression [7].

Tests for Linitis Plastica

• The tests for linitis plastica are similar to those for stomach cancer. Sometimes linitis plastica can be difficult to diagnose [9].

Unfortunately, I couldn't find any specific information on diagnostic tests for "obsolete anaplastic gastric carcinoma". This may be due to the fact that this term is not commonly used or recognized in medical literature.

References: [1] Not applicable [2] Context #2 [3] Context #3 [5] Context #5 [7] Context #7 [9] Context #9

The differential diagnosis of obsolete anaplastic gastric carcinoma involves considering various conditions that may present similarly to this type of cancer.

According to search results, one important differential diagnosis is undifferentiated gastric carcinoma, which poses diagnostic and therapeutic challenges [14]. This condition is characterized by anaplastic cells lacking distinct features of cytological or architectural differentiation. Recent studies have suggested an association between this carcinoma and deficiencies in the SWI/SNF complex, particularly mutations in subunits such as SMARCA4.

Other differential diagnoses for obsolete anaplastic gastric carcinoma may include:

• Gastric adenocarcinoma, which requires biomarker testing for HER2 (ERBB2) to guide treatment [9]
• Clear cell sarcoma of the stomach
• GIST sarcoma
• Sarcomatoid carcinoma
• Malignant melanoma lymphoma and myeloma

It's also worth noting that gastric cancer is a complex disease with diverse biological and genetic features, and various etiological factors, including environmental and genetic factors [10]. Gastric carcinoma has extensive morphological heterogeneity, including different structures, growth patterns, cell differentiation, and histogenesis.

In terms of specific characteristics, anaplastic gastric carcinoma may be distinguished from other conditions by its lack of distinct cytological or architectural features. However, the differential diagnosis for this type of cancer can be challenging due to its rarity and similarity to other types of gastric carcinomas.

References:

[9] Gastric adenocarcinoma requires biomarker testing for HER2 (ERBB2) to guide treatment. [10] Gastric carcinoma has diverse biological and genetic features and various etiological factors, including environmental and genetic factors.