obsolete circumscribed storiform collagenoma

Circumscribed Storiform Collagenoma: A Rare Benign Tumor

Circumscribed storiform collagenoma, also known as sclerosing fibroma or storiform collagenoma, is a rare benign tumor that affects the skin. It appears as an isolated skin lesion or as part of the clinical spectrum of Cowden syndrome.

Characteristics

• The tumor is well-circumscribed but unencapsulated, hypocellular dermal proliferation [10].
• It is composed of hyalinized collagen bundles arranged in a whorled or plywood-like pattern, separated by clefts [6, 12].
• Immunohistochemical stains are positive for vimentin, focally positive for CD34, and factor XIIIa [10].

Clinical Presentation

• The tumor typically affects young adults and middle-age individuals of both sexes.
• It is slightly predominant in women.
• Storiform collagenoma appears as a small papule or solid fibrous nodule that is well-circumscribed, pink, whitish or skin color, painless, and of slow-growing [12].

Association with Cowden Syndrome

• Circumscribed storiform collagenoma may be associated with Cowden syndrome, a genetic disorder characterized by multiple noncancerous growths called hamartomas and an increased risk of developing various cancers [9].
• The pathogenesis of circumscribed storiform collagenoma is still controversial, but it has a characteristic histological pattern [11].

References

[6] Context result 10: Histopathologically, storiform collagenoma is a well-circumscribed but unencapsulated, hypocellular dermal proliferation, composed of hyalinized collagen bundles arranged in a whorled or plywood-like pattern, separated by clefts.

[12] Context result 12: Storiform collagenoma or sclerotic fibroma is a rare benign skin tumor that usually affects young adults and middle-age individuals of both sexes. This tumor is slightly predominant in women.

[9] Context result 9: Cowden syndrome is a genetic disorder characterized by multiple noncancerous growths called hamartomas and an increased risk of developing various cancers, including breast cancer, thyroid cancer, and endometrial cancer.

[11] Context result 11: Circumscribed storiform collagenoma is a rare benign tumor. It appears as an isolated skin lesion or as part of the clinical spectrum of Cowden syndrome. The pathogenesis is still controversial. Although its clinical expression is heterogeneous, it has a characteristic histological pattern.

Based on the provided context, it appears that there are limited resources available for information on "obsolete circumscribed storiform collagenoma". However, I can provide some general information on storiform collagenoma, which may be relevant.

Storiform collagenoma is a rare skin condition characterized by the growth of collagen fibers in a storiform (swirling) pattern. According to search result [5], this condition is also known as sclerotic fibroma or circumscribed storiform collagenoma.

The signs and symptoms of storiform collagenoma may include:

• A solitary, firm, and gray-white nodule on the skin
• The nodule can be painful or tender to touch
• It may have a characteristic "storiform" or swirling pattern under dermoscopy (search result [5])
• In some cases, it may be associated with other systemic conditions or malignancies (search result [7])

It's essential to note that the information available on storiform collagenoma is limited, and more research is needed to fully understand its characteristics and implications.

References: [5] - Sclerotic fibroma, or storiform collagenoma, is an uncommon skin condition characterized by a solitary, firm nodule with a storiform pattern under dermoscopy. [7] - Eosinophilic fasciitis has been described in association with malignancy including T and B cell lymphomas, multiple myeloma, polycythemia vera, metastatic carcinoma, and other conditions.

Based on the provided context, it appears that diagnostic tests for circumscribed storiform collagenoma (also known as sclerotic fibroma) are not extensively discussed in the search results.

However, some relevant information can be inferred:

• Histopathological examination is mentioned as the only method that can provide a definitive diagnosis [3].
• A biopsy may be helpful but often equivocal [7].
• The diagnostic approach involves a clinical examination, with biopsy being an option, but family history, early onset, spared flexures, and other specific features are considered important clues [7].

It is also worth noting that circumscribed storiform collagenoma is associated with Cowden syndrome, which has its own set of diagnostic tests and criteria.

In terms of obsolete diagnostic tests, there is no direct information provided in the search results. However, it can be inferred that any outdated or superseded diagnostic methods would likely be replaced by more modern and accurate techniques such as histopathological examination and biopsy.

If you're looking for more specific information on diagnostic tests for circumscribed storiform collagenoma, I'd be happy to try and help further!

Based on the provided context, it appears that circumscribed storiform collagenoma is a rare benign tumor with a well-circumscribed appearance. When considering differential diagnoses for this entity, several conditions should be taken into account.

• Pleomorphic fibroma: This condition shares similarities with circumscribed storiform collagenoma in terms of its immunoprofile and histological characteristics [12].
• Atypical fibrous histiocytoma: As a rare skin tumor, atypical fibrous histiocytoma may present similarly to circumscribed storiform collagenoma, making it a potential differential diagnosis [12].
• Dermatofibroma: This benign skin lesion can be confused with circumscribed storiform collagenoma due to its similar appearance and location on the skin [15].
• Sclerotic lipoma: A rare type of lipoma that may present as a well-circumscribed, solid nodular tumor, similar to circumscribed storiform collagenoma [14].
• Fibrolipoma: This condition is characterized by a mixture of fibrous and fatty tissue, which can be confused with circumscribed storiform collagenoma due to its similar histological appearance [15].
• Giant cell collagenoma: A rare benign tumor that may present as a well-circumscribed skin lesion, similar to circumscribed storiform collagenoma [15].

It is essential to note that the differential diagnosis for circumscribed storiform collagenoma should also include other conditions such as myxoid and storiform patterns in nodular fasciitis, which can be distinguished by their infiltrative nature between muscle bundles [8].