obsolete eruptive collagenoma

Obsolete Eruptive Collagenoma

Eruptive collagenoma, also known as papular elastorrhexis or nevus anelasticus, is a rare skin condition characterized by the sudden appearance of multiple small papules or nodules on the trunk and arms. These lesions are typically firm, white-to-skin-colored, and vary in size but are usually less than 1 cm.

Key Features

• Abrupt Onset: The disease is characterized by an abrupt onset, with patients often presenting with a sudden appearance of raised cutaneous papules or nodules.
• Multiple Lesions: Eruptive collagenoma typically presents as multiple small papules or nodules on the trunk and arms.
• Histopathological Features: Histology of eruptive collagenoma shows disarranged and dense coarse collagen fibers in the dermis, with decreased or degenerated elastic fibers.

References

• [1] The clinical picture is characterized by inelastic, loose, hanging skin more marked in flexural areas, giving the appearance of premature aging. (Source: Search Result 2)
• [4, 6] The age of onset is commonly within the first decade of life, with patients presenting with multiple asymptomatic papules or nodules on the trunk and arms. (Source: Search Results 14)
• [13] Histopathological features of decreased or degenerated elastic fibers are a hallmark of eruptive collagenoma. (Source: Search Result 13)

Eruptive Collagenoma Signs and Symptoms

Eruptive collagenoma, a rare skin condition, presents with distinct signs and symptoms. The following are the common manifestations of this condition:

• Multiple Papules or Nodules: Eruptive collagenoma is characterized by an abrupt onset of multiple small papules or nodules on the skin [10]. These lesions can be flesh-colored or yellowish in appearance [9].
• Asymptomatic Masses: Patients usually present with asymptomatic masses, which may sometimes be accompanied by systemic symptoms such as fatigue, fever, and night sweats [5].
• Generalized Lymphadenopathy: In some cases, patients may experience generalized lymphadenopathy (swollen lymph nodes) [5].
• Papular Elastorrhexis: A rare manifestation of eruptive collagenoma is papular elastorrhexis, which presents as multiple discrete non-follicular skin-colored papules of size ranging from 1-5mm with no tendency to coalesce [6].

These signs and symptoms can vary in severity and may be localized or generalized. It's essential to note that eruptive collagenoma is a rare condition, and not all patients will exhibit these characteristics.

References: [5] - Context result 5 [6] - Context result 6 [9] - Context result 9 [10] - Context result 10

Diagnostic Tests for Eruptive Collagenoma

Eruptive collagenoma, a rare type of connective tissue nevus, can be challenging to diagnose. However, several diagnostic tests and methods have been employed to confirm the presence of this condition.

• Histopathology: A key diagnostic tool for eruptive collagenoma is histopathological examination of skin biopsies. Microscopic findings reveal dense, coarse collagen fibers and decreased or fragmented elastic fibers compared to normal skin [10].
• Clinical Examination: Physical examination plays a crucial role in diagnosing eruptive collagenoma. The condition typically presents as multiple asymptomatic papules or nodules on the trunk and extremities [10].
• Imaging Studies: Imaging studies, such as ultrasound or MRI, may be used to rule out other conditions that may present similarly to eruptive collagenoma.
• Genetic Testing: In some cases, genetic testing may be recommended to rule out associated genetic disorders, such as multiple endocrine neoplasia type 1 (MEN1) [3].

Differential Diagnosis

It is essential to differentiate eruptive collagenoma from other conditions that may present similarly. These include:

• Nevus anelasticus: A condition characterized by the presence of abnormal elastic fibers.
• Papular acne scars: A type of skin lesion resulting from previous acne outbreaks.
• Eruptive collagenoma variants: Other rare types of connective tissue nevi that may present similarly to eruptive collagenoma.

References

[3] - The diagnosis was eruptive collagenoma based on history, physical examination, and histology [1]. [10] - Histopathology revealed dense, coarse collagen fibers by hematoxylin-eosin stain and decreased, fragmented elastic fibers by Elastic stain compared with the normal skin [10].

Note: The numbers in square brackets refer to the context numbers provided.

Based on the provided context, it appears that there are various treatments mentioned for eruptive collagenoma, but I'll focus on drug treatments.

According to search result [11], eruptive cutaneous collagenoma is a connective tissue nevi of unknown etiology. However, in some cases, treatment with systemic immunosuppressive treatments has been successful.

Search result [5] mentions that 8 patients were treated successfully with systemic immunosuppressive treatments, including biologics such as etanercept and ustekinumab. Specifically, it's mentioned that 5 patients were treated with biologics (etanercept [41,42], ustekinumab [52]).

Additionally, search result [13] mentions a case of eruptive collagenoma associated with adalimumab treatment of juvenile rheumatoid arthritis. However, this is more of an anecdotal report and not a general recommendation for treating eruptive collagenoma.

It's worth noting that the context also mentions other treatments such as excision (search result [7]) and laser ablation (search result [7]), but these are not drug-based treatments.

In summary, while there are some reports of successful treatment with systemic immunosuppressive treatments, including biologics like etanercept and ustekinumab, the evidence is limited and more research is needed to confirm their effectiveness in treating eruptive collagenoma.

Based on the provided context, the differential diagnosis for obsolete eruptive collagenoma includes:

• Eruptive xanthomas
• Molluscum contagiosum
• Anetoderma
• Elastic nevus (which can occur as a solitary lesion or associated with osteopoikilosis of Buschke-Ollendorf syndrome)
• Nevus anelasticus (an acquired nevus characterized by the presence of abnormal elastic fibers)
• Papular elastorrhexis
• Scars

These conditions should be considered in the differential diagnosis of eruptive collagenoma, as they can present with similar clinical features. A biopsy may be required to make a definitive diagnosis.

According to [11], the differential diagnoses include eruptive xanthomas, molluscum contagiosum, anetoderma, elastic nevus, scars, and anetoderma are the differential diagnosis of eruptive collagenoma. Elastic nevus can occur as solitary lesion or associated with osteopoikilosis of Buschke Ollendorf syndrome.

Additionally, [12] mentions that elastic nevus, nevus anelasticus, and papular elastorrhexis are also part of the differential diagnosis for eruptive collagenoma.

It's worth noting that a definitive diagnosis of eruptive collagenoma requires histopathological examination and clinical correlation.