Discuss This Drug

voriconazole

CHEBI:CHEBI_10023

Definition

A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.

Chemical Information

Molecular Formula
C16H14F3N5O
Molecular Mass
349.31050
Charge
0
SMILES
C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
InChI
InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
InChIKey
BCEHBSKCWLPMDN-MGPLVRAMSA-N

Alternative Names

  • (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
  • (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
  • VCZ
  • Vfend
  • voriconazol
  • voriconazole
  • voriconazole
  • voriconazolum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
121243
oboInOwl#hasDbXref
Wikipedia:Voriconazole
core#notation
CHEBI:10023

Additional References

Wikipedia:Voriconazole

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_12662
DRON_00010000
121243
oboInOwl#hasDbXref
Wikipedia:Voriconazole
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#id
CHEBI:10023
oboInOwl#hasAlternativeId
CHEBI:127308
generic_name
VORICONAZOLE
brand_name
VFEND
brand_name_base
VFEND
product_ndc
0904-6596
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50183
package_marketing_start_date
26-DEC-23
package_description
30 TABLET, FILM COATED in 1 BOTTLE (63629-8734-1)
listing_expiration_date
20241231
marketing_start_date
20030328
spl_id
665bf370-317f-4443-89c7-3cf0e0a86ffb
labeler_name
Mylan Pharmaceuticals Inc.
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
application_number
ANDA205034
core#notation
CHEBI:10023
active_ingredient_strength
75 kg/75kg
pharm_class_epc
Azole Antifungal [EPC]
pharm_class
Cytochrome P450 2C9 Inhibitors [MoA]
pharm_class_cs
Azoles [CS]
pharm_class_moa
Cytochrome P450 2C9 Inhibitors [MoA]
nui
N0000185504
active_ingredient_name
VORICONAZOLE
upc
0368083321017
spl_set_id
bda70104-d84b-4d3f-9ca0-5f4f1ca816ad
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rxcui
546624
manufacturer_name
Hainan Poly Pharm. Co., Ltd
unii
JFU09I87TR
route
INTRAVENOUS
package_ndc
0904-6596-04
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_108354
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect1328
owl#annotatedSource
t93037
owl#someValuesFrom
t2909214