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zileuton

CHEBI:CHEBI_10112

Definition

A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.

Chemical Information

Molecular Formula
C11H12N2O2S
Molecular Mass
236.29126
Charge
0
SMILES
CC(N(O)C(N)=O)c1cc2ccccc2s1
InChI
InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
InChIKey
MWLSOWXNZPKENC-UHFFFAOYSA-N

Alternative Names

  • (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
  • 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
  • Leutrol
  • N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea
  • N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea
  • zileuton
  • Zileuton
  • zileutonum
  • Zyflo

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
40575
oboInOwl#hasDbXref
Wikipedia:Zileuton
core#notation
CHEBI:10112

Additional References

Wikipedia:Zileuton

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

DRON_00010000
40575
oboInOwl#hasDbXref
Wikipedia:Zileuton
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#id
CHEBI:10112
generic_name
ZILEUTON
brand_name
ZYFLO
brand_name_base
ZYFLO
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
TABLET, MULTILAYER, EXTENDED RELEASE
marketing_start_date
19961209
labeler_name
Solara Active Pharma Sciences Limited
product_ndc
14501-0056
application_number
ANDA212670
spl_id
0bbe21b4-6dd0-abab-e063-6394a90ab19d
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_64964
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_parent_hydride
http://purl.obolibrary.org/obo/CHEBI_35858
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000062
core#notation
CHEBI:10112
rxcui
211777
route
ORAL
active_ingredient_strength
5 kg/5kg
package_marketing_start_date
16-APR-20
manufacturer_name
Golden State Medical Supply, Inc.
active_ingredient_name
ZILEUTON
package_ndc
14501-0056-2
package_description
50 kg in 1 DRUM (14501-0056-2)
unii
V1L22WVE2S
spl_set_id
bc29c998-1324-46aa-8386-e5b2fc9e0b16
nui
N0000008683
pharm_class_epc
5-Lipoxygenase Inhibitor [EPC]
pharm_class
5-Lipoxygenase Inhibitors [MoA]
pharm_class_pe
Decreased Leukotriene Production [PE]
pharm_class_moa
5-Lipoxygenase Inhibitors [MoA]
upc
0331722044127
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0080816
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect1423
owl#annotatedSource
t93053
owl#someValuesFrom
t3005099