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efavirenz

CHEBI:CHEBI_119486

Definition

1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.

Chemical Information

Molecular Formula
C14H9ClF3NO2
Molecular Mass
315.67500
Charge
0
SMILES
FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1
InChI
InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
InChIKey
XPOQHMRABVBWPR-ZDUSSCGKSA-N

Alternative Names

  • (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE
  • (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
  • (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
  • 6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
  • Efavirenz

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
195085
oboInOwl#hasDbXref
Wikipedia:Efavirenz
core#notation
CHEBI:119486

Additional References

Wikipedia:Efavirenz

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
195085
oboInOwl#hasDbXref
Wikipedia:Efavirenz
oboInOwl#id
CHEBI:119486
oboInOwl#hasAlternativeId
CHEBI:4760
generic_name
EFAVIRENZ
brand_name
Efavirenz
brand_name_base
Efavirenz
product_type
BULK INGREDIENT
dosage_form
CAPSULE
marketing_category
BULK INGREDIENT
labeler_name
Jetpharma S.A.
product_ndc
70366-002
application_number
ANDA091579
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_53756
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
package_marketing_start_date
02-APR-11
package_description
1 BAG in 1 DRUM (70366-002-01) / 1 BAG in 1 BAG / 20 kg in 1 BAG
package_ndc
65862-106-15
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20110402
spl_id
ad612c1e-e4cf-4938-9a08-ea7f921d114d
core#notation
CHEBI:119486
rxcui
349477
active_ingredient_strength
1 kg/1
pharm_class_moa
Non-Nucleoside Reverse Transcriptase Inhibitors [MoA]
pharm_class
Non-Nucleoside Analog [EXT]
nui
N0000009948
manufacturer_name
Cipla USA Inc.
active_ingredient_name
EFAVIRENZ
unii
JE6H2O27P8
spl_set_id
13ca3456-e5bf-4bb1-af95-b1378658a358
upc
0365862049100
pharm_class_epc
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6045
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect1639
owl#annotatedSource
t96721
owl#someValuesFrom
t1071766