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Plerixafor

CHEBI:CHEBI_125354

Definition

An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

Chemical Information

Molecular Formula
C28H54N8
Molecular Mass
502.796
Charge
0
SMILES
C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3
InChI
InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2
InChIKey
YIQPUIGJQJDJOS-UHFFFAOYSA-N

Alternative Names

  • 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
  • 1,1'-(benzene-1,4-diyldimethanediyl)bis(1,4,8,11-tetraazacyclotetradecane)
  • 1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane)
  • AMD 3100
  • AMD-3100
  • AMD3100
  • JKL 169
  • JM3100
  • Mozobil
  • plerixafor
  • plerixaforum
  • SDZ SID 791

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
733003
oboInOwl#hasDbXref
Wikipedia:Plerixafor
core#notation
CHEBI:125354

Additional References

Wikipedia:Plerixafor

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rxcui
828703
listing_expiration_date
20241231
marketing_start_date
20081215
package_marketing_start_date
29-AUG-16
manufacturer_name
Fresenius Kabi Usa, LLC
route
SUBCUTANEOUS
active_ingredient_strength
24 mg/1.2mL
labeler_name
Gland Pharma Limited
spl_id
bf37c037-175b-45cf-bed3-ced897418f28
active_ingredient_name
PLERIXAFOR
package_ndc
71288-155-01
package_description
1 VIAL, SINGLE-DOSE in 1 CARTON (71288-155-01) / 1.2 mL in 1 VIAL, SINGLE-DOSE
unii
S915P5499N
spl_set_id
646d87cd-e2e0-49cf-96e6-112701230969
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
733003
oboInOwl#hasDbXref
Wikipedia:Plerixafor
oboInOwl#id
CHEBI:125354
brand_name
PLERIXAFOR
brand_name_base
PLERIXAFOR
generic_name
PLERIXAFOR
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, SOLUTION
product_ndc
71288-155
application_number
ANDA215698
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50847
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_37401
core#notation
CHEBI:125354
nui
N0000178324
pharm_class_epc
Hematopoietic Stem Cell Mobilizer [EPC]
pharm_class
Increased Hematopoietic Stem Cell Mobilization [PE]
pharm_class_pe
Increased Hematopoietic Stem Cell Mobilization [PE]
upc
0304804320013
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0060973
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113521
owl#annotatedSource
t96715
owl#someValuesFrom
t3020284