Discuss This Drug

phosphonoformic acid

CHEBI:CHEBI_127780

Definition

Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Chemical Information

Molecular Formula
CH3O5P
Molecular Mass
126.00530
Charge
0
SMILES
OC(=O)P(O)(O)=O
InChI
InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)
InChIKey
ZJAOAACCNHFJAH-UHFFFAOYSA-N

Alternative Names

  • carboxyphosphonic acid
  • dihydroxyphosphanecarboxylic acid oxide
  • Foscarmet
  • foscarnet
  • Foscarnet
  • FOSCARNET
  • PHOSPHONOFORMIC ACID
  • phosphonomethanoic acid

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:127780
DRON_00010000
33562
oboInOwl#hasDbXref
Wikipedia:Foscarnet

Additional References

Wikipedia:Foscarnet

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:127780
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rxcui
1734377
listing_expiration_date
20241231
pharm_class
Pyrophosphate Analog [EXT]
manufacturer_name
Clinigen Limited
route
INTRAVENOUS
package_marketing_start_date
09-JUL-20
active_ingredient_strength
6000 mg/250mL
marketing_start_date
20231222
spl_id
148361f3-4366-9f0f-e063-6394a90a69e0
active_ingredient_name
FOSCARNET SODIUM
package_ndc
0143-9192-01
package_description
10 CARTON in 1 CASE (0143-9192-01) / 1 BOTTLE in 1 CARTON / 250 mL in 1 BOTTLE
unii
964YS0OOG1
spl_set_id
b612e6f1-584f-4188-b96e-1a9adfcfe75c
upc
0301439192015
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
33562
oboInOwl#hasDbXref
Wikipedia:Foscarnet
oboInOwl#id
CHEBI:127780
oboInOwl#hasAlternativeId
CHEBI:8158
brand_name
Foscavir
brand_name_base
Foscavir
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, SOLUTION
labeler_name
Clinigen Limited
generic_name
foscarnet sodium
product_ndc
0143-9192
application_number
ANDA213987
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_63330
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_44976
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_91254
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113850
has_treatment
http://purl.obolibrary.org/obo/DOID_640
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_91254
owl#annotatedSource
t96771
owl#someValuesFrom
t3001826