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dacomitinib

CHEBI:CHEBI_132268

Definition

A member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin-1-yl)but-2-enoyl group.

Chemical Information

Molecular Formula
C24H25ClFN5O2
Molecular Mass
469.940
Charge
0
SMILES
ClC=1C=C(NC2=NC=NC=3C2=CC(NC(=O)\C=C\CN4CCCCC4)=C(OC)C3)C=CC1F
InChI
InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
InChIKey
LVXJQMNHJWSHET-AATRIKPKSA-N

Alternative Names

  • (2E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-(piperidin-1-yl)but-2-enamide
  • dacomitinib
  • dacomitinibum
  • PF 00299804-03
  • PF-00299804
  • PF-00299804-03

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2058849
oboInOwl#hasDbXref
Wikipedia:Dacomitinib
core#notation
CHEBI:132268

Additional References

Wikipedia:Dacomitinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
2058849
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oboInOwl#id
CHEBI:132268
core#notation
CHEBI:132268
generic_name
dacomitinib
rxcui
2058932
product_type
HUMAN PRESCRIPTION DRUG
marketing_category
NDA
route
ORAL
listing_expiration_date
20241231
dosage_form
TABLET, FILM COATED
active_ingredient_strength
45 mg/1
labeler_name
Pfizer Laboratories Div Pfizer Inc
manufacturer_name
Pfizer Laboratories Div Pfizer Inc
marketing_start_date
20181004
package_marketing_start_date
20181004
brand_name
Vizimpro
brand_name_base
Vizimpro
product_ndc
0069-0197
application_number
NDA211288
spl_id
7a7e890e-6637-4aff-b4fd-96815d2f1f3f
active_ingredient_name
DACOMITINIB
package_ndc
0069-0197-30
package_description
30 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (0069-0197-30)
unii
5092U85G58
spl_set_id
4ab27d2f-e385-4e9c-b324-fa69c10b855a
upc
0300690197302
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_74440
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http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_1324
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https://w3id.org/def/predibionto#has_side_effect1835
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t96793
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t3326909