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elbasvir

CHEBI:CHEBI_132967

Definition

A complex organic heterotetracyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with grazoprevir (under the brand name Zepatier) for treatment of chronic HCV genotypes 1 or 4 infection in adults.

Chemical Information

Molecular Formula
C49H55N9O7
Molecular Mass
882.019
Charge
0
SMILES
C=1C(C2=CN=C(N2)[C@]3(N(CCC3)C([C@H](C(C)C)NC(=O)OC)=O)[H])=CC4=C(C1)N5C(=C4)C=6C=CC(=CC6O[C@H]5C=7C=CC=CC7)C=8NC(=NC8)[C@@]9(CCCN9C(=O)[C@@H](NC(=O)OC)C(C)C)[H]
InChI
InChI=1S/C49H55N9O7/c1-27(2)41(54-48(61)63-5)45(59)56-20-10-14-37(56)43-50-25-34(52-43)30-17-19-36-32(22-30)23-39-33-18-16-31(24-40(33)65-47(58(36)39)29-12-8-7-9-13-29)35-26-51-44(53-35)38-15-11-21-57(38)46(60)42(28(3)4)55-49(62)64-6/h7-9,12-13,16-19,22-28,37-38,41-42,47H,10-11,14-15,20-21H2,1-6H3,(H,50,52)(H,51,53)(H,54,61)(H,55,62)/t37-,38-,41-,42-,47-/m0/s1
InChIKey
BVAZQCUMNICBAQ-PZHYSIFUSA-N

Alternative Names

  • elbasvir
  • MK 8742
  • MK-8742
  • MK8742
  • methyl {(2S)-1-[(2S)-2-{4-[(6S)-3-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazin-10-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:132967
DRON_00010000
1734628
oboInOwl#hasDbXref
Wikipedia:Elbasvir

Additional References

Wikipedia:Elbasvir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:132967
pharm_class
Hepatitis C Virus NS5A Inhibitor [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1734628
oboInOwl#hasDbXref
Wikipedia:Elbasvir
oboInOwl#id
CHEBI:132967
rxcui
1734642
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
route
ORAL
active_ingredient_strength
1 kg/kg
dosage_form
POWDER
nui
N0000182638
pharm_class_moa
HCV NS3/4A Protease Inhibitors [MoA]
pharm_class_epc
Hepatitis C Virus NS3/4A Protease Inhibitor [EPC]
labeler_name
MSD International GmbH
manufacturer_name
Merck Sharp & Dohme LLC
marketing_start_date
20160128
package_marketing_start_date
28-JAN-16
generic_name
elbasvir and grazoprevir
product_ndc
50473-0097
spl_id
b8eb802a-890d-4f9c-a0bd-fe2ecbd81735
active_ingredient_name
GRAZOPREVIR ANHYDROUS
package_ndc
50473-0097-0
package_description
1 BAG in 1 DRUM (50473-0097-0) / 8 kg in 1 BAG
brand_name
ZEPATIER
brand_name_base
ZEPATIER
application_number
NDA208261
unii
8YE81R1X1J
spl_set_id
164dc02a-9180-426a-b8b5-04ab39d2bbd4
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_85185
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_109494
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect1891
owl#annotatedSource
t100310
owl#someValuesFrom
t2999271