elbasvir
CHEBI:CHEBI_132967
Definition
A complex organic heterotetracyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with grazoprevir (under the brand name Zepatier) for treatment of chronic HCV genotypes 1 or 4 infection in adults.
Chemical Information
- Molecular Formula
- C49H55N9O7
- Molecular Mass
- 882.019
- Charge
- 0
- SMILES
- C=1C(C2=CN=C(N2)[C@]3(N(CCC3)C([C@H](C(C)C)NC(=O)OC)=O)[H])=CC4=C(C1)N5C(=C4)C=6C=CC(=CC6O[C@H]5C=7C=CC=CC7)C=8NC(=NC8)[C@@]9(CCCN9C(=O)[C@@H](NC(=O)OC)C(C)C)[H]
- InChI
- InChI=1S/C49H55N9O7/c1-27(2)41(54-48(61)63-5)45(59)56-20-10-14-37(56)43-50-25-34(52-43)30-17-19-36-32(22-30)23-39-33-18-16-31(24-40(33)65-47(58(36)39)29-12-8-7-9-13-29)35-26-51-44(53-35)38-15-11-21-57(38)46(60)42(28(3)4)55-49(62)64-6/h7-9,12-13,16-19,22-28,37-38,41-42,47H,10-11,14-15,20-21H2,1-6H3,(H,50,52)(H,51,53)(H,54,61)(H,55,62)/t37-,38-,41-,42-,47-/m0/s1
- InChIKey
- BVAZQCUMNICBAQ-PZHYSIFUSA-N
Alternative Names
- elbasvir
- MK 8742
- MK-8742
- MK8742
- methyl {(2S)-1-[(2S)-2-{4-[(6S)-3-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazin-10-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
Treatment Applications
Drug Classification
-
carbamate esterView Class →
CHEBI:23003
-
imidazolesView Class →
CHEBI:24780
-
ring assemblyView Class →
CHEBI:36820
-
organic heterotetracyclic compoundView Class →
CHEBI:38163
-
N-acylpyrrolidineView Class →
CHEBI:46766
-
L-valine derivativeView Class →
CHEBI:84129
-
t96422
-
t96447
-
t96515
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:132967
- DRON_00010000
- 1734628
- oboInOwl#hasDbXref
- Wikipedia:Elbasvir
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- core#notation
- CHEBI:132967
- pharm_class
- Hepatitis C Virus NS5A Inhibitor [EPC]
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1734628
- oboInOwl#hasDbXref
- Wikipedia:Elbasvir
- oboInOwl#id
- CHEBI:132967
- rxcui
- 1734642
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- listing_expiration_date
- 20251231
- route
- ORAL
- active_ingredient_strength
- 1 kg/kg
- dosage_form
- POWDER
- nui
- N0000182638
- pharm_class_moa
- HCV NS3/4A Protease Inhibitors [MoA]
- pharm_class_epc
- Hepatitis C Virus NS3/4A Protease Inhibitor [EPC]
- labeler_name
- MSD International GmbH
- manufacturer_name
- Merck Sharp & Dohme LLC
- marketing_start_date
- 20160128
- package_marketing_start_date
- 28-JAN-16
- generic_name
- elbasvir and grazoprevir
- product_ndc
- 50473-0097
- spl_id
- b8eb802a-890d-4f9c-a0bd-fe2ecbd81735
- active_ingredient_name
- GRAZOPREVIR ANHYDROUS
- package_ndc
- 50473-0097-0
- package_description
- 1 BAG in 1 DRUM (50473-0097-0) / 8 kg in 1 BAG
- brand_name
- ZEPATIER
- brand_name_base
- ZEPATIER
- application_number
- NDA208261
- unii
- 8YE81R1X1J
- spl_set_id
- 164dc02a-9180-426a-b8b5-04ab39d2bbd4
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_85185
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_109494
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect1891
- owl#annotatedSource
- t100310
- owl#someValuesFrom
- t2999271