Discuss This Drug

velpatasvir

CHEBI:CHEBI_133009

Definition

A complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes.

Chemical Information

Molecular Formula
C49H54N8O8
Molecular Mass
883.004
Charge
0
SMILES
C(N1[C@@H](C)CC[C@H]1C2=NC=3C=CC=4C=C5C6=CC=C(C7=CN=C([C@@H]8C[C@H](COC)CN8C(=O)[C@@H](C=9C=CC=CC9)NC(=O)OC)N7)C=C6COC5=CC4C3N2)(=O)[C@H](C(C)C)NC(=O)OC
InChI
InChI=1S/C49H54N8O8/c1-26(2)41(54-48(60)63-5)47(59)57-27(3)12-17-38(57)45-51-36-16-14-30-20-35-33-15-13-31(19-32(33)25-65-40(35)21-34(30)43(36)53-45)37-22-50-44(52-37)39-18-28(24-62-4)23-56(39)46(58)42(55-49(61)64-6)29-10-8-7-9-11-29/h7-11,13-16,19-22,26-28,38-39,41-42H,12,17-18,23-25H2,1-6H3,(H,50,52)(H,51,53)(H,54,60)(H,55,61)/t27-,28-,38-,39-,41-,42+/m0/s1
InChIKey
FHCUMDQMBHQXKK-CDIODLITSA-N

Alternative Names

  • GS 5816
  • GS-5816
  • GS5816
  • velpatasvir
  • methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}-1,11-dihydro[2]benzopyrano[4',3':6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:133009
DRON_00010000
1799206
oboInOwl#hasDbXref
Wikipedia:Velpatasvir

Additional References

Wikipedia:Velpatasvir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:133009
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1799206
oboInOwl#hasDbXref
Wikipedia:Velpatasvir
oboInOwl#id
CHEBI:133009
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
PELLET
marketing_start_date
20181114
labeler_name
GILEAD SCIENCES IRELAND UNLIMITED COMPANY
generic_name
VELPATASVIR SDD
brand_name
Sofosbuvir and Velpatasvir
brand_name_base
Sofosbuvir and Velpatasvir
product_ndc
48087-0124
application_number
NDA214187
spl_id
f8225225-2ac8-888e-e053-6294a90aebd3
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_85185
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rxcui
2584201
route
ORAL
active_ingredient_strength
10 kg/10kg
pharm_class_moa
Organic Anion Transporting Polypeptide 2B1 Inhibitors [MoA]
pharm_class
Organic Anion Transporting Polypeptide 2B1 Inhibitors [MoA]
nui
N0000190109
package_marketing_start_date
23-NOV-16
manufacturer_name
Gilead Sciences, Inc.
active_ingredient_name
VELPATASVIR
unii
KCU0C7RS7Z
pharm_class_epc
Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor [EPC]
package_ndc
48087-0124-0
package_description
10 kg in 1 DRUM (48087-0124-0)
spl_set_id
d0c1a945-4440-4b5c-81aa-693ed3db597c
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112636
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect1936
owl#annotatedSource
t100735
owl#someValuesFrom
t3861937