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crisaborole

CHEBI:CHEBI_134677

Definition

A member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults.

Chemical Information

Molecular Formula
C14H10BNO3
Molecular Mass
251.07537
Charge
0
SMILES
C1=C(C=C2C(=C1)B(OC2)O)OC3=CC=C(C=C3)C#N
InChI
InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChIKey
USZAGAREISWJDP-UHFFFAOYSA-N

Alternative Names

  • 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
  • AN 2728
  • AN-2728
  • AN2728
  • crisaborole
  • Crisaborole topical ointment 2%
  • Eucrisa

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1865953
oboInOwl#hasDbXref
Reaxys:11622826
core#notation
CHEBI:134677

Additional References

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Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1865953
oboInOwl#hasDbXref
Reaxys:11622826
oboInOwl#id
CHEBI:134677
core#notation
CHEBI:134677
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68844
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_3310
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect2119
owl#annotatedSource
t100646
owl#someValuesFrom
t3088443