crisaborole
CHEBI:CHEBI_134677
Definition
A member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults.
Chemical Information
- Molecular Formula
- C14H10BNO3
- Molecular Mass
- 251.07537
- Charge
- 0
- SMILES
- C1=C(C=C2C(=C1)B(OC2)O)OC3=CC=C(C=C3)C#N
- InChI
- InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
- InChIKey
- USZAGAREISWJDP-UHFFFAOYSA-N
Alternative Names
- 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
- AN 2728
- AN-2728
- AN2728
- crisaborole
- Crisaborole topical ointment 2%
- Eucrisa
Drug Classification
-
nitrileView Class →
CHEBI:18379
-
aromatic etherView Class →
CHEBI:35618
-
benzoxaboroleView Class →
CHEBI:78240
-
t99765
-
t100168
-
t100593
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 1865953
- oboInOwl#hasDbXref
- Reaxys:11622826
- core#notation
- CHEBI:134677
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1865953
- oboInOwl#hasDbXref
- Reaxys:11622826
- oboInOwl#id
- CHEBI:134677
- generic_name
- Crisaborole
- brand_name
- Eucrisa
- brand_name_base
- Eucrisa
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- listing_expiration_date
- 20241231
- marketing_start_date
- 20180712
- dosage_form
- OINTMENT
- labeler_name
- Esteve Quimica, S.A.
- product_ndc
- 51686-0005
- application_number
- NDA207695
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_68844
- core#notation
- CHEBI:134677
- rxcui
- 1865962
- route
- TOPICAL
- active_ingredient_strength
- 12 kg/12kg
- nui
- N0000182960
- pharm_class_epc
- Phosphodiesterase 4 Inhibitor [EPC]
- pharm_class
- Phosphodiesterase 4 Inhibitors [MoA]
- pharm_class_moa
- Phosphodiesterase 4 Inhibitors [MoA]
- manufacturer_name
- Pfizer Laboratories Div Pfizer Inc
- spl_id
- 0fe0669f-df9f-9f05-e063-6394a90a0db6
- active_ingredient_name
- CRISABOROLE
- package_ndc
- 51686-0005-0
- package_description
- 25 kg in 1 DRUM (51686-0005-0)
- package_marketing_start_date
- 19-APR-18
- unii
- Q2R47HGR7P
- spl_set_id
- 609b77de-1ca3-4783-b8f5-01a9c0f1d77d
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_3310
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect2119
- owl#annotatedSource
- t100646
- owl#someValuesFrom
- t3088443