vericiguat
CHEBI:CHEBI_142432
Definition
A pyrazolopyridine that is 5-fluoro-1H-pyrazolo[3,4-b]pyridine in which the amino hydrogen at position 1 has been substituted by a 2-fluorobenzyl group and the hydrogen at position 3 has been substituted by a 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. It is a soluble guanylate cyclase stimulator which is used for treatment of chronic heart failure.
Chemical Information
- Molecular Formula
- C19H16F2N8O2
- Molecular Mass
- 426.380
- Charge
- 0
- SMILES
- N=1C(=NC(=C(C1N)NC(=O)OC)N)C=2C3=C(N(N2)CC=4C(=CC=CC4)F)N=CC(=C3)F
- InChI
- InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)
- InChIKey
- QZFHIXARHDBPBY-UHFFFAOYSA-N
Alternative Names
- BAY-1021189
- BAY1021189
- methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate
- methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
- MK-1242
- vericiguat
- vericiguatum
Drug Classification
-
carbamate esterView Class →
CHEBI:23003
-
processed material
-
organofluorine compoundView Class →
CHEBI:37143
-
aminopyrimidineView Class →
CHEBI:38338
-
pyrazolopyridineView Class →
CHEBI:46699
-
t111560
-
t112255
-
t112327
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 2475830
- oboInOwl#hasDbXref
- Reaxys:22098890
- core#notation
- CHEBI:142432
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 2475830
- oboInOwl#hasDbXref
- Reaxys:22098890
- oboInOwl#id
- CHEBI:142432
- generic_name
- Vericiguat
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- listing_expiration_date
- 20251231
- route
- ORAL
- dosage_form
- POWDER
- marketing_start_date
- 20210119
- package_marketing_start_date
- 19-JAN-21
- labeler_name
- MSN Life Sciences Private Limited
- manufacturer_name
- Merck Sharp & Dohme LLC
- brand_name
- VERQUVO
- brand_name_base
- VERQUVO
- product_ndc
- 68554-0164
- application_number
- NDA214377
- spl_id
- 1b3cf1f8-f262-8541-e063-6394a90a4358
- package_ndc
- 68554-0164-1
- package_description
- 1 kg in 1 DRUM (68554-0164-1)
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_76022
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- core#notation
- CHEBI:142432
- rxcui
- 2475860
- active_ingredient_strength
- 1 kg/kg
- active_ingredient_name
- VERICIGUAT
- unii
- LV66ADM269
- spl_set_id
- 17056d73-1b1b-4bf2-9c07-b7a9367f0d6d
- nui
- N0000190485
- upc
- 0300065028026
- pharm_class_epc
- Soluble Guanylate Cyclase Stimulator [EPC]
- pharm_class
- Guanylate Cyclase Stimulators [MoA]
- pharm_class_moa
- Guanylate Cyclase Stimulators [MoA]
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect5283
- owl#annotatedSource
- t112572
- owl#someValuesFrom
- t3745410