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Lorlatinib

CHEBI:CHEBI_143117

Definition

A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.

Chemical Information

Molecular Formula
C21H19FN6O2
Molecular Mass
406.421
Charge
0
SMILES
C=1C=C(C=C2C1C(=O)N(C)CC3=NN(C(=C3C=4C=NC(=C(O[C@@H]2C)C4)N)C#N)C)F
InChI
InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
InChIKey
IIXWYSCJSQVBQM-LLVKDONJSA-N

Alternative Names

  • (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
  • loratinib
  • Lorbrena
  • lorlatinib
  • lorlatinibum
  • PF-06463922
  • PF06463922
  • PFE-PKIS 10

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2103164
oboInOwl#hasDbXref
Wikipedia:Lorlatinib
core#notation
CHEBI:143117

Additional References

Wikipedia:Lorlatinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
2103164
oboInOwl#hasDbXref
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oboInOwl#id
CHEBI:143117
core#notation
CHEBI:143117
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62434
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has_treatment
http://purl.obolibrary.org/obo/DOID_5193
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t112585
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t3350440