Discuss This Drug

Binimetinib

CHEBI:CHEBI_145371

Definition

A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.

Chemical Information

Molecular Formula
C17H15BrF2N4O3
Molecular Mass
441.233
Charge
0
SMILES
BrC=1C=C(F)C(NC=2C(F)=C3N=CN(C3=CC2C(=O)NOCCO)C)=CC1
InChI
InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey
ACWZRVQXLIRSDF-UHFFFAOYSA-N

Alternative Names

  • 5-(4-bromo-2-fluoroanilino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide
  • 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • ARRY 162
  • ARRY 438162
  • ARRY-162
  • ARRY-438162
  • binimetinib
  • binimetinibum
  • MEK-162
  • MEK162
  • Mektovi
  • N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide
  • NVP-MEK162

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:145371
DRON_00010000
2049122
oboInOwl#hasDbXref
Wikipedia:Binimetinib

Additional References

Wikipedia:Binimetinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:145371
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2049122
generic_name
BINIMETINIB
oboInOwl#hasDbXref
Wikipedia:Binimetinib
oboInOwl#id
CHEBI:145371
rxcui
2049133
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
route
ORAL
dosage_form
POWDER
active_ingredient_strength
1 kg/kg
marketing_start_date
20180627
labeler_name
Valary Lab Private Limited
package_marketing_start_date
27-JUN-18
active_ingredient_name
BINIMETINIB
brand_name
MEKTOVI
brand_name_base
MEKTOVI
product_ndc
54893-0119
application_number
NDA210498
manufacturer_name
Array BioPharma Inc.
spl_id
1e622f59-1185-64ad-e063-6294a90ac652
package_ndc
54893-0119-2
package_description
30 kg in 1 DRUM (54893-0119-2)
unii
181R97MR71
spl_set_id
6c3408ac-d401-4925-8a03-26591afbc240
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_79091
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6085
owl#annotatedSource
t112575
owl#someValuesFrom
t3299826