Discuss This Drug

gilteritinib

CHEBI:CHEBI_145372

Definition

A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation.

Chemical Information

Molecular Formula
C29H44N8O3
Molecular Mass
552.724
Charge
0
SMILES
CCC1=NC(C(=O)N)=C(NC2=CC=C(N3CCC(CC3)N4CCN(C)CC4)C(OC)=C2)N=C1NC5CCOCC5
InChI
InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)
InChIKey
GYQYAJJFPNQOOW-UHFFFAOYSA-N

Alternative Names

  • 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-2-pyrazinecarboxamide
  • 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide
  • 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-[(oxan-4-yl)amino]pyrazine-2-carboxamide
  • ASP 2215
  • ASP-2215
  • ASP2215
  • gilteritinib
  • gilteritinibum
  • Xospata

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2105806
oboInOwl#hasDbXref
Wikipedia:Gilteritinib
core#notation
CHEBI:145372

Additional References

Wikipedia:Gilteritinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2105806
oboInOwl#hasDbXref
Wikipedia:Gilteritinib
oboInOwl#id
CHEBI:145372
core#notation
CHEBI:145372
dosage_form
POWDER
listing_expiration_date
20241231
active_ingredient_strength
1 kg/kg
marketing_start_date
20181128
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
labeler_name
Astellas Pharma Inc.
package_marketing_start_date
28-NOV-18
generic_name
Gilteritinib Fumarate
product_ndc
54893-0120
spl_id
0cde53f3-481f-4731-e063-6294a90a1c48
active_ingredient_name
GILTERITINIB FUMARATE
package_ndc
54893-0120-2
package_description
30 kg in 1 DRUM (54893-0120-2)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62434
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http://purl.obolibrary.org/obo/chebi#3_STAR
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http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_8692
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https://w3id.org/def/predibionto#has_side_effect5324
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t112487
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t3350151