Discuss This Drug

pexidartinib

CHEBI:CHEBI_145373

Definition

A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).

Chemical Information

Molecular Formula
C20H15ClF3N5
Molecular Mass
417.820
Charge
0
SMILES
C1=C(C=C2C(=N1)NC=C2CC3=CN=C(C=C3)NCC4=CC=C(N=C4)C(F)(F)F)Cl
InChI
InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
InChIKey
JGWRKYUXBBNENE-UHFFFAOYSA-N

Alternative Names

  • 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine
  • CML-261
  • pexidartinib
  • pexidartinibum
  • PLX-3397
  • PLX3397
  • Turalio

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:145373
DRON_00010000
2183102
oboInOwl#hasDbXref
Wikipedia:Pexidartinib

Additional References

Wikipedia:Pexidartinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:145373
pharm_class
Kinase Inhibitors [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2183102
oboInOwl#hasDbXref
Wikipedia:Pexidartinib
oboInOwl#id
CHEBI:145373
brand_name
Turalio
brand_name_base
Turalio
rxcui
2626399
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date
20251231
route
ORAL
dosage_form
CAPSULE
active_ingredient_strength
20 kg/20kg
marketing_start_date
20190805
package_marketing_start_date
14-OCT-22
labeler_name
Daiichi Sankyo, Inc.
generic_name
Pexidartinib HCl
product_ndc
50384-0750
spl_id
c96330e8-d8f5-5fc6-e053-2a95a90abe24
active_ingredient_name
PEXIDARTINIB HYDROCHLORIDE
package_ndc
50384-0750-0
package_description
20 kg in 1 DRUM (50384-0750-0)
application_number
NDA211810
manufacturer_name
Daiichi Sankyo, Inc.
unii
YS6WAI3XN7
spl_set_id
7b0ec4bf-b2ac-49ee-96af-7740ad3f2e16
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62434
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_2704
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect5354
owl#annotatedSource
t112539
owl#someValuesFrom
t3463552