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glasdegib

CHEBI:CHEBI_145428

Definition

A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a (2R,4S)-4-{[(4-cyanophenyl)carbamoyl]amino}-1-methylpiperidin-2-yl group at position 2. It is a hedgehog signalling pathway inhibitor that acts by binding to Smoothened (SMO) receptors and blocking signal transduction (IC50 = 5 nM). It is used in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients (aged >= 75 years), or who have medical conditions that prevent the use of standard chemotherapy.

Chemical Information

Molecular Formula
C21H22N6O
Molecular Mass
374.448
Charge
0
SMILES
N([C@H]1C[C@@H](N(CC1)C)C=2NC=3C(N2)=CC=CC3)C(=O)NC=4C=CC(=CC4)C#N
InChI
InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1
InChIKey
SFNSLLSYNZWZQG-VQIMIIECSA-N

Alternative Names

  • 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea
  • Daurismo
  • glasdegib
  • glasdegibum
  • N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-N'-(4-cyanophenyl)urea
  • PF-04449913
  • PF-4449913
  • PF-913

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2105845
oboInOwl#hasDbXref
Wikipedia:Glasdegib
core#notation
CHEBI:145428

Additional References

Wikipedia:Glasdegib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
2105845
oboInOwl#hasDbXref
Wikipedia:Glasdegib
oboInOwl#id
CHEBI:145428
core#notation
CHEBI:145428
brand_name
Daurismo
brand_name_base
Daurismo
generic_name
glasdegib
rxcui
2105860
product_type
HUMAN PRESCRIPTION DRUG
marketing_category
NDA
listing_expiration_date
20251231
route
ORAL
active_ingredient_strength
25 mg/1
dosage_form
TABLET, FILM COATED
marketing_start_date
20181210
package_marketing_start_date
20181210
labeler_name
Pfizer Laboratories Div Pfizer Inc
manufacturer_name
Pfizer Laboratories Div Pfizer Inc
product_ndc
0069-1531
application_number
NDA210656
spl_id
9695bbad-259b-4ac3-80af-36f1ca94d433
active_ingredient_name
GLASDEGIB
package_ndc
0069-1531-30
package_description
30 TABLET, FILM COATED in 1 BOTTLE (0069-1531-30)
unii
K673DMO5H9
spl_set_id
204a6f7e-c9a4-472b-abd2-9527bda64d17
nui
N0000184148
upc
0300691531303
pharm_class_epc
Hedgehog Pathway Inhibitor [EPC]
pharm_class
Smoothened Receptor Antagonists [MoA]
pharm_class_moa
Smoothened Receptor Antagonists [MoA]
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_66908
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http://purl.obolibrary.org/obo/DOID_0081092
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