Discuss This Drug

ivosidenib

CHEBI:CHEBI_145430

Definition

A tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation.

Chemical Information

Molecular Formula
C28H22ClF3N6O3
Molecular Mass
582.970
Charge
0
SMILES
C=1(C=NC=C(C1)F)N([C@H](C(NC2CC(C2)(F)F)=O)C3=C(C=CC=C3)Cl)C([C@@]4(CCC(N4C5=NC=CC(=C5)C#N)=O)[H])=O
InChI
InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1
InChIKey
WIJZXSAJMHAVGX-DHLKQENFSA-N

Alternative Names

  • (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
  • AG-120
  • ivosidenib
  • ivosidenibum
  • N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxo-L-prolinamide
  • Tibsovo

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:145430
DRON_00010000
2049873
oboInOwl#hasDbXref
Wikipedia:Ivosidenib

Additional References

Wikipedia:Ivosidenib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:145430
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2049873
oboInOwl#hasDbXref
Wikipedia:Ivosidenib
oboInOwl#id
CHEBI:145430
generic_name
Ivosidenib
rxcui
2049884
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
route
ORAL
dosage_form
POWDER
active_ingredient_strength
1 kg/kg
nui
N0000193988
pharm_class_moa
Isocitrate Dehydrogenase 1 Inhibitors [MoA]
pharm_class
Isocitrate Dehydrogenase 1 Inhibitors [MoA]
marketing_start_date
20211019
package_marketing_start_date
20-JUL-18
product_ndc
72694-617
labeler_name
Servier Pharmaceutical LLC
spl_id
0f85fbd5-16ff-4563-834e-91aac62a1242
active_ingredient_name
IVOSIDENIB
package_ndc
72694-617-60
package_description
1 BOTTLE in 1 CARTON (72694-617-60) / 60 TABLET, FILM COATED in 1 BOTTLE
pharm_class_epc
Isocitrate Dehydrogenase 1 Inhibitor [EPC]
brand_name
TIBSOVO
brand_name_base
TIBSOVO
application_number
NDA211192
manufacturer_name
Servier Pharmaceutical LLC
unii
Q2PCN8MAM6
spl_set_id
65d254c0-67ad-42c4-b972-ad463b755b2d
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_145410
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_5934
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect5417
owl#annotatedSource
t112491
owl#someValuesFrom
t3300519