Discuss This Drug

motixafortide

CHEBI:CHEBI_145536

Definition

A heterodetic cyclic peptide that has antineoplastic activity. It is a CXC chemokine receptor 4 (CXCR4) antagonist with an IC50 value of 0.8 nM and is currently under clinical investigation for the treatment of hematological malignancies, solid tumors, and stem cell mobilization. It was granted orphan drug designation by the FDA for the treatment of pancreatic cancer in 2019.

Chemical Information

Molecular Formula
C97H144FN33O19S2
Molecular Mass
2159.550
Charge
0
SMILES
[H][C@@]12CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CC1=CC2=C(C=CC=C2)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C1=CC=C(F)C=C1
InChI
InChI=1S/C97H144FN33O19S2/c98-60-33-31-58(32-34-60)78(135)119-65(19-8-42-113-93(104)105)79(136)121-68(21-10-44-115-95(108)109)83(140)126-73(51-56-25-30-57-14-1-2-15-59(57)48-56)87(144)130-75-53-152-151-52-74(88(145)118-63(77(101)134)18-7-41-112-92(102)103)129-84(141)69(23-12-46-117-97(111)150)122-81(138)66(20-9-43-114-94(106)107)124-86(143)72(50-55-28-37-62(133)38-29-55)128-90(147)76-24-13-47-131(76)91(148)70(17-4-6-40-100)125-82(139)64(16-3-5-39-99)120-80(137)67(22-11-45-116-96(110)149)123-85(142)71(127-89(75)146)49-54-26-35-61(132)36-27-54/h1-2,14-15,25-38,48,63-76,132-133H,3-13,16-24,39-47,49-53,99-100H2,(H2,101,134)(H,118,145)(H,119,135)(H,120,137)(H,121,136)(H,122,138)(H,123,142)(H,124,143)(H,125,139)(H,126,140)(H,127,146)(H,128,147)(H,129,141)(H,130,144)(H4,102,103,112)(H4,104,105,113)(H4,106,107,114)(H4,108,109,115)(H3,110,116,149)(H3,111,117,150)/t63-,64-,65-,66-,67-,68-,69-,70+,71-,72-,73-,74-,75-,76-/m0/s1
InChIKey
JJVZSYKFCOBILL-KZGZZEQFSA-N

Alternative Names

  • 4F-benzoyl-TN14003
  • BKT 140
  • BKT-140
  • BKT140
  • BL 8040
  • BL-8040
  • BL8040
  • motixafortida
  • motixafortide
  • motixafortidum
  • TF 14016
  • TF-14016
  • TF14016
  • TN-14003
  • (3S,6S,9S,12R,17R,20S,23S,26S,29R,34aS)-26,29-bis(4-aminobutyl)-N-[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]-17-{[(2S)-2-{[(2S)-5-carbamimidamido-2-{[(2S)-5-carbamimidamido-2-(4-fluorobenzamido)pentanoyl]amino}pentanoyl]amino}-3-(naphthalen-2-yl)propanoyl]amino}-6-(3-carbamimidamidopropyl)-9,23-bis[3-(carbamoylamino)propyl]-3,20-bis(4-hydroxybenzyl)-1,4,7,10,18,21,24,27,30-nonaoxotriacontahydro-1H,16H-pyrrolo[2,1-p][1,2,5,8,11,14,17,20,23,26,29]dithianonaazacyclodotriacontine-12-carboxamide (non-preferred name)

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2664896
oboInOwl#hasDbXref
Wikipedia:Motixafortide
core#notation
CHEBI:145536

Additional References

Wikipedia:Motixafortide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

owl#annotatedSource
t112591
owl#someValuesFrom
t3992341
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2664896
oboInOwl#hasDbXref
Wikipedia:Motixafortide
oboInOwl#id
CHEBI:145536
core#notation
CHEBI:145536
rxcui
2664906
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
route
SUBCUTANEOUS
marketing_start_date
20230908
active_ingredient_strength
62 mg/1.7mL
package_marketing_start_date
11-SEP-23
labeler_name
BioLineRx USA Inc
generic_name
MOTIXAFORTIDE
brand_name
Aphexda
brand_name_base
Aphexda
product_ndc
58862-0177
application_number
NDA217159
manufacturer_name
BioLineRx USA Inc
spl_id
1a4cd4c3-df77-5e29-e063-6394a90a04e6
active_ingredient_name
MOTIXAFORTIDE
package_ndc
58862-0177-1
package_description
125 g in 1 BOTTLE, GLASS (58862-0177-1)
unii
3ZPX60DV8A
spl_set_id
f7cdc584-ebf0-a68e-e053-6294a90a9ea9
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68495
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class