Discuss This Drug

remdesivir

CHEBI:CHEBI_145994

Definition

A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.

Chemical Information

Molecular Formula
C27H35N6O8P
Molecular Mass
602.585
Charge
0
SMILES
[C@]1(O[C@@H]([C@H]([C@H]1O)O)CO[P@@](N[C@H](C(OCC(CC)CC)=O)C)(OC=2C=CC=CC2)=O)(C#N)C=3N4N=CN=C(C4=CC3)N
InChI
InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1
InChIKey
RWWYLEGWBNMMLJ-YSOARWBDSA-N

Alternative Names

  • (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
  • 2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
  • 2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate
  • GS 5734
  • GS-5734
  • GS5734
  • remdesivir
  • remdesivirum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2284718
oboInOwl#hasDbXref
Wikipedia:Remdesivir
core#notation
CHEBI:145994

Additional References

Wikipedia:Remdesivir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2284718
oboInOwl#hasDbXref
Wikipedia:Remdesivir
oboInOwl#id
CHEBI:145994
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
CAPSULE
marketing_start_date
20190710
labeler_name
Intra-Cellular Therapies, Inc
generic_name
Lumateperone tosylate non mc
product_ndc
72060-142
spl_id
8b20f6bb-a32a-49f0-a836-e070786123a7
package_ndc
72060-142-40
brand_name
CAPLYTA
brand_name_base
CAPLYTA
application_number
NDA209500
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_147281
core#notation
CHEBI:145994
rxcui
2607535
package_marketing_start_date
10-JUL-19
nui
N0000175430
pharm_class_epc
Atypical Antipsychotic [EPC]
pharm_class
Atypical Antipsychotic [EPC]
active_ingredient_strength
42 mg/1
active_ingredient_name
LUMATEPERONE
package_description
30 CAPSULE in 1 BOTTLE (72060-142-40)
manufacturer_name
Intra-Cellular Therapies, Inc
unii
70BSQ12069
spl_set_id
db730b06-6351-47fd-8183-e61e61bbead5
upc
0372060121408
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_4393
owl#annotatedSource
t112567
owl#someValuesFrom
t3535291