Discuss This Drug

monomethyl fumarate

CHEBI:CHEBI_167450

Definition

A dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1.

Chemical Information

Molecular Formula
C5H6O4
Molecular Mass
130.099
Charge
0
SMILES
COC(=O)\C=C\C(O)=O
InChI
InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+
InChIKey
NKHAVTQWNUWKEO-NSCUHMNNSA-N

Alternative Names

  • (2E)-4-methoxy-4-oxobut-2-enoic acid
  • (E)-4-methoxy-4-oxobut-2-enoic acid
  • Bafiertam
  • fumarate de monomethyle
  • fumarato de monometilo
  • fumaric acid monomethyl ester
  • methyl hydrogen fumarate
  • MMF
  • mono-methyl fumarate
  • monomethyl fumarate
  • monomethylfumarate
  • monomethylis fumaras

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1546433
oboInOwl#hasDbXref
Wikipedia:Monomethyl_fumarate
core#notation
CHEBI:167450

Additional References

Wikipedia:Monomethyl_fumarate

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1546433
oboInOwl#hasDbXref
Wikipedia:Monomethyl_fumarate
oboInOwl#id
CHEBI:167450
core#notation
CHEBI:167450
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_49103
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_18012
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect8045
owl#annotatedSource
t127030
owl#someValuesFrom
t3866557