Discuss This Drug

nirmatrelvir

CHEBI:CHEBI_170007

Definition

An azabicyclohexane that is (1R,5S)-3-azabicyclo[3.1.0]hexane substituted by {(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}aminoacyl, 3-methyl-N-(trifluoroacetyl)-L-valinamide, methyl and methyl groups at positions 2S, 3, 6 and 6, respectively. It is the first orally administered inhibitor of SARS-CoV-2 main protease developed by Pfizer and used in combination with ritonavir for the treatment of COVID-19.

Chemical Information

Molecular Formula
C23H32F3N5O4
Molecular Mass
499.535
Charge
0
SMILES
[H][C@]12CN([C@H](C(=O)N[C@@H](C[C@]3([H])CCNC3=O)C#N)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C
InChI
InChI=1S/C23H32F3N5O4/c1-21(2,3)16(30-20(35)23(24,25)26)19(34)31-10-13-14(22(13,4)5)15(31)18(33)29-12(9-27)8-11-6-7-28-17(11)32/h11-16H,6-8,10H2,1-5H3,(H,28,32)(H,29,33)(H,30,35)/t11-,12-,13-,14-,15-,16+/m0/s1
InChIKey
LIENCHBZNNMNKG-OJFNHCPVSA-N

Alternative Names

  • (1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
  • nirmatrelvir
  • nirmatrelvirum
  • PF 07321332
  • PF-07321332
  • PF07321332

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:170007
DRON_00010000
2587892
oboInOwl#hasDbXref
Wikipedia:Nirmatrelvir

Additional References

Wikipedia:Nirmatrelvir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:170007
rxcui
2599543
active_ingredient_strength
1 kg/kg
package_marketing_start_date
26-NOV-21
manufacturer_name
Pfizer Laboratories Div Pfizer Inc
package_description
1 BAG in 1 BOX (53869-2085-9) / 235000 TABLET, FILM COATED in 1 BAG
spl_set_id
8a99d6d6-fd9e-45bb-b1bf-48c7f761232a
active_ingredient_name
NIRMATRELVIR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2587892
oboInOwl#hasDbXref
Wikipedia:Nirmatrelvir
oboInOwl#id
CHEBI:170007
oboInOwl#hasAlternativeId
CHEBI:192699
generic_name
Nirmatrelvir
brand_name
Paxlovid
brand_name_base
Paxlovid
dosage_form
POWDER
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
marketing_start_date
20221230
labeler_name
MSN Life Sciences Private Limited
product_ndc
53869-2085
application_number
NDA217188
spl_id
ed942b8c-9f22-4626-8b8c-8835463448a9
package_ndc
53869-2085-9
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_147285
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_0050305
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect8480
owl#annotatedSource
t130684
owl#someValuesFrom
t3839789